Search Results - "Baptista, Melisa"

The Parkinson's Disease Protein DJ-1 Is Neuroprotective Due to Cysteine-Sulfinic Acid-Driven Mitochondrial Localization by Canet-Avilés, Rosa M., Wilson, Mark A., Miller, David W., Ahmad, Rili, McLendon, Chris, Bandyopadhyay, Sourav, Baptista, Melisa J., Ringe, Dagmar, Petsko, Gregory A., Cookson, Mark R.

“…Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of DJ-1 is unknown, but an acidic isoform accumulates after oxidative…”
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Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS by Kirby, Janine, Halligan, Eugene, Baptista, Melisa J., Allen, Simon, Heath, Paul R., Holden, Hazel, Barber, Sian C., Loynes, Catherine A., Wood-Allum, Clare A., Lunec, Joseph, Shaw, Pamela J.

“…Familial amyotrophic lateral sclerosis (FALS) is caused, in 20% of cases, by mutations in the Cu/Zn superoxide dismutase gene (SOD1). Although motor neuron…”
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L166P Mutant DJ-1, Causative for Recessive Parkinson's Disease, Is Degraded through the Ubiquitin-Proteasome System by Miller, David W., Ahmad, Rili, Hague, Stephen, Baptista, Melisa J., Canet-Aviles, Rosa, McLendon, Chris, Carter, Donald M., Zhu, Peng-Peng, Stadler, Julia, Chandran, Jayanth, Klinefelter, Gary R., Blackstone, Craig, Cookson, Mark R.

“…Mutations in a gene on chromosome 1, DJ-1, have been reported recently to be associated with recessive, earlyonset Parkinson's disease. While one mutation is a…”
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Co‐ordinate transcriptional regulation of dopamine synthesis genes by α‐synuclein in human neuroblastoma cell lines by Baptista, Melisa J., O'Farrell, Casey, Daya, Sneha, Ahmad, Rili, Miller, David W., Hardy, John, Farrer, Matthew J., Cookson, Mark R.

“…Abnormal accumulation of α‐synuclein in Lewy bodies is a neuropathological hallmark of both sporadic and familial Parkinson's disease (PD). Although mutations…”
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Microarray analysis reveals induction of heat shock proteins mRNAs by the torsion dystonia protein, TorsinA by Baptista, Melisa J., O'Farrell, Casey, Hardy, John, Cookson, Mark R.

“…An in-frame deletion (ΔE302/303) in the TorsinA gene has been demonstrated to be responsible for primary torsion dystonia, showing dominant inheritance with…”
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Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease by Baptista, Melisa J, Cookson, Mark R, Miller, David W

“…Dominant mutations in the gene for alpha-synuclein, a small presynaptic protein, can cause Parkinson's disease. Although there is still substantial debate…”
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Heterotrisomy, a significant contributing factor to ventricular septal defect associated with Down syndrome? by BAPTISTA, Melisa J, FAIRBROTHER, Una L, KESSLING, Anna M, HOWARD, Catherine M, FARRER, Matthew J, DAVIES, Gail E, TRIKKA, Dimitra, MARATOU, Klio, REDINGTON, Andrew, GREVE, Gottfried, NJØLSTAD, Pal Rasmus

“…Down syndrome (DS; trisomy 21) is associated with a wide range of variable clinical features, one of the most common being congenital heart defects (CHD). We…”
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Parkin Protects against the Toxicity Associated with Mutant α-Synuclein: Proteasome Dysfunction Selectively Affects Catecholaminergic Neurons by Petrucelli, Leonard, O'Farrell, Casey, Lockhart, Paul J., Baptista, Melisa, Kehoe, Kathryn, Vink, Liselot, Choi, Peter, Wolozin, Benjamin, Farrer, Matthew, Hardy, John, Cookson, Mark R.

“…One hypothesis for the etiology of Parkinson's disease (PD) is that subsets of neurons are vulnerable to a failure in proteasome-mediated protein turnover…”
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Parkin and -Synuclein: Opponent Actions in The Pathogenesis of Parkinson’S Disease by Baptista, Melisa J., Cookson, Mark R., Miller, David W.

“…Dominant mutations in the gene for •-synuclein, a small presynaptic protein, can cause Parkinson’s disease. Although there is still substantial debate about…”
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Dominant torsinA mutations in cellular systems by Baptista, Melisa J, O'Farrell, Casey A, Cookson, Mark R

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An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered alpha -Synuclein Metabolism and Oxidative Damage by Sherer, Todd B, Betarbet, Ranjita, Stout, Amy K, Lund, Serena, Baptista, Melisa, Panov, Alexander V, Cookson, Mark R, Greenamyre, J. Timothy

“…Chronic systemic complex I inhibition caused by rotenone exposure induces features of Parkinson's disease (PD) in rats, including selective nigrostriatal…”
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Parkin and &b.alpha; -Synuclein: Opponent Actions in The Pathogenesis of Parkinson'S Disease by Baptista, Melisa J, Cookson, Mark R, Miller, David W

“…Dominant mutations in the gene for times -synuclein, a small presynaptic protein, can cause Parkinson's disease. Although there is still substantial debate…”
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Mutant SOD I alters the motor neuronal transcriptome : implications for familial ALS by KIRBY, Janine, HALLIGAN, Eugene, SHAW, Pamela J, BAPTISTA, Melisa J, ALLEN, Simon, HEATH, Paul R, HOLDEN, Hazel, BARBER, Sian C, LOYNES, Catherine A, WOOD-ALLUM, Clare A, LUNEC, Joseph

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Parkin Protects against the Toxicity Associated with Mutant [alpha]-Synuclein: Proteasome Dysfunction Selectively Affects Catecholaminergic Neurons by Petrucelli, Leonard, O'Farrell, Casey, Lockhart, Paul J, Baptista, Melisa, Kehoe, Kathryn, Vink, Liselot, Choi, Peter, Wolozin, Benjamin, Farrer, Matthew, Hardy, John, Cookson, Mark R

“…One hypothesis for the etiology of Parkinson's disease (PD) is that subsets of neurons are vulnerable to a failure in proteasome-mediated protein turnover…”
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Parkin Protects against the Toxicity Associated with Mutant α-Synuclein by Petrucelli, Leonard, O'Farrell, Casey, Lockhart, Paul J., Baptista, Melisa, Kehoe, Kathryn, Vink, Liselot, Choi, Peter, Wolozin, Benjamin, Farrer, Matthew, Hardy, John, Cookson, Mark R.

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