Search Results - "Bao, Zhengzheng"

Narazaciclib, a novel multi-kinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models by Yang, Tao, Ke, Hang, Liu, Jinping, An, Xiaoyu, Xue, Jia, Ning, Jinying, Hao, Feng, Xiong, Lingxin, Chen, Cen, Wang, Yueying, Zheng, Jia, Gao, Bing, Bao, Zhengzheng, Gong, Kefeng, Zhang, Lei, Zhang, Faming, Guo, Sheng, Li, Qi-Xiang

“…CSF1R is a receptor tyrosine kinase responsible for the growth/survival/polarization of macrophages and overexpressed in some AML patients. We hypothesized…”
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A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology by Xu, Xiaoxi, Kumari, Rajendra, Zhou, Jun, Chen, Jing, Mao, Binchen, Wang, Jingjing, Zheng, Meiling, Tu, Xiaolong, An, Xiaoyu, Chen, Xiaobo, Zhang, Likun, Tian, Xiaoli, Wang, Haojie, Dong, Xin, Bao, Zhengzheng, Guo, Sheng, Ouyang, Xuesong, Shang, Limei, Wang, Fei, Yan, Xuefei, Zhang, Rui, Vries, Robert G J, Clevers, Hans, Li, Qi-Xiang

“…Patient-derived tumor xenograft (PDX)/organoid (PDO), driven by cancer stem cells (CSC), are considered the most predictive models for translational oncology…”
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The C-terminal region of S100A4 is important for its metastasis-inducing properties by SHU ZHANG, GUOZHENG WANG, DONG LIU, ZHENGZHENG BAO, FERNIG, David G, RUDLAND, Philip S, BARRACLOUGH, Roger

“…The EF-hand protein, S100A4, binds calcium ions and interacts specifically in vitro with protein targets. Elevated levels of S100A4 have been shown to produce…”
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Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells by Yam, Noymi, Levin, Jason, Bao, Zhengzheng, Qian, Wubin, Levin, Victor A.

“…Treatment of infiltrative glioma presents a number of unique challenges due to poor penetration of typical chemotherapeutic agents into the infiltrating edge…”
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The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance by Al Fayi, Majed Saad, Gou, Xiaojun, Forootan, Shiva S, Al-Jameel, Waseem, Bao, Zhengzheng, Rudland, Philip R, Cornford, Philip A, Hussain, Syed A, Ke, Youqiang

“…In contrast to numerous studies conducted to investigate the crucial role of fatty acid binding protein 5 (FABP5) in prostate cancer, investigations on the…”
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Abstract 1807: Anti-tumor activity of a novel structural class of NAMPT inhibitor-based ADCs in models of hematologic and solid tumor indications by Sommer, Anette, Hammer, Stefanie, Berndt, Sandra, Wengner, Antje M., Boehnke, Niels, Berger, Markus, Griebenow, Nils, Steffen, Andreas, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Giese, Anja, Quanz, Maria, Bao, Zhengzheng, Wu, Xiuli, Weinmann, Hilmar, Linden, Lars, Kreft, Bertolt, Mumberg, Dominik

“…Abstract Nicotinamide phosphoribosyl-transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway, generating nicotinamide adenine dinucleotide (NAD)…”
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Abstract 1038: Cell-based screening identifies gene expression signature correlated with sensitivity to PI3K-mTOR dual inhibitor BEZ235 by Zhang, Jing, Guo, Sheng, Bao, Zhengzheng, Shang, Limei, Wen, Xiao, Wery, Jean-Pierre, Ning, Jinying

“…Abstract The PI3K-mTOR pathway is one of the major signaling cascades that promote tumor growth and cell survival. Multiple inhibitors targeting this important…”
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Abstract 5665: HX301 (ON1232580) a novel kinase inhibitor with potent activity against CSF1R and FLT3, shows strong anti-AML activity in defined preclinical models by An, Xiaoyu, Li, Henry, Xue, Linda, Liu, Jinping, Xiong, Lingxin, Ke, Hang, Chen, Cen, Gao, Bing, Zheng, Jia, Bao, Zhengzheng, Guo, Sheng, Zhang, Lei, Zhang, Faming

“…Abstract Acute myeloid leukemia (AML) is an aggressive leukemia of myeloid lineage with different subtypes of varying treatments/outcomes and a global annual…”
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A novel cutaneous Fatty Acid-binding protein-related signaling pathway leading to malignant progression in prostate cancer cells by Bao, Zhengzheng, Malki, Mohammad I, Forootan, Shiva S, Adamson, Janet, Forootan, Farzad S, Chen, Danqing, Foster, Christopher S, Rudland, Philip S, Ke, Youqiang

“…Cutaneous fatty acid-binding protein (C-FABP), a cancer promoter and metastasis inducer, is overexpressed in the majority of prostatic carcinomas…”
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A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology by Xiaoxi Xu, Rajendra Kumari, Jun Zhou, Jing Chen, Binchen Mao, Jingjing Wang, Meiling Zheng, Xiaolong Tu, Xiaoyu An, Xiaobo Chen, Likun Zhang, Xiaoli Tian, Haojie Wang, Xin Dong, Zhengzheng Bao, Sheng Guo, Xuesong Ouyang, Limei Shang, Fei Wang, Xuefei Yan, Rui Zhang, Robert G. J. Vries, Hans Clevers, Qi-Xiang Li

“…Patient-derived tumor xenograft (PDX)/organoid (PDO), driven by cancer stem cells (CSC), are considered the most predictive models for translational oncology…”
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Magnetite nanoparticles doped photoresist derived carbon as a suitable substratum for nerve cell culture by Zhu, Zanzan, Rezhdo, Olijora, Perrone, Matthew, Bao, Zhengzheng, Munir, Ahsan, Wang, Jianlong, Zhou, H. Susan, Shao, Jiahui

“…[Display omitted] ► Photo-resist derived carbon obtained using photolithographic technique was doped with magnetite nanoparticles. ► The physical property of…”
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Characterization of proteins purified from a beta(1) integrin affinity column: A novel ecm molecule and a muscle-specific integrin alpha subunit by Bao, Zhengzheng

“…Previous work on the distribution of the $\beta$1 integrins on skeletal muscle revealed that integrin occupied all of the major junctional regions on muscle…”
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