Search Results - "Bao, Dingjiu"

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH) by Tully, David C, Rucker, Paul V, Chianelli, Donatella, Williams, Jennifer, Vidal, Agnès, Alper, Phil B, Mutnick, Daniel, Bursulaya, Badry, Schmeits, James, Wu, Xiangdong, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Seidel, H. Martin, Molteni, Valentina, Liu, Bo, Phimister, Andrew, Joseph, Sean B, Laffitte, Bryan

“…The farnesoid X receptor (FXR) is a nuclear receptor that acts as a master regulator of bile acid metabolism and signaling. Activation of FXR inhibits bile…”
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Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents by Hernandez, Eloy D., Zheng, Lianxing, Kim, Young, Fang, Bin, Liu, Bo, Valdez, Reginald A., Dietrich, William F., Rucker, Paul V., Chianelli, Donatella, Schmeits, James, Bao, Dingjiu, Zoll, Jocelyn, Dubois, Claire, Federe, Glenn C., Chen, Lihao, Joseph, Sean B., Klickstein, Lloyd B., Walker, John, Molteni, Valentina, McNamara, Peter, Meeusen, Shelly, Tully, David C., Badman, Michael K., Xu, Jie, Laffitte, Bryan

“…Farnesoid X receptor (FXR) agonism is emerging as an important potential therapeutic mechanism of action for multiple chronic liver diseases. The bile…”
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Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes by Thomson, S C, Deng, A, Bao, D, Satriano, J, Blantz, R C, Vallon, V

“…In early diabetes, the kidney grows and the glomerular filtration rate (GFR) increases. This growth is linked to ornithine decarboxylase (ODC). The study of…”
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Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism by WATTS, Lynnetta M, VARA PRASAD MANCHEM, HONG YAN ZHANG, COX, Amy L, JACOBS, Steven J, MICHAEL, M. Dodson, SLOOP, Kyle W, BHANOT, Sanjay, LEEDOM, Thomas A, RIVARD, Amber L, MCKAY, Robert A, DINGJIU BAO, NEROLADAKIS, Teri, MONIA, Brett P, BODENMILLER, Diane M, CAO, Julia Xiao-Chun

“…Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in…”
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Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice by XING XIAN YU, MURRAY, Susan F, BHANOT, Sanjay, PANDEY, Sanjay K, BOOTEN, Sheri L, DINGJIU BAO, SONG, Xiu-Zhen, KELLY, Susan, SONGYUAN CHEN, MCKAY, Robert, MONIA, Brett P

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Adenosine formed by 5′-nucleotidase mediates tubuloglomerular feedback by Thomson, Scott, Bao, Dingjiu, Deng, Aihua, Vallon, Volker

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Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis by Chianelli, Donatella, Rucker, Paul V, Roland, Jason, Tully, David C, Nelson, John, Liu, Xiaodong, Bursulaya, Badry, Hernandez, Eloy D, Wu, Jane, Prashad, Mahavir, Schlama, Thierry, Liu, Yugang, Chu, Alan, Schmeits, James, Huang, David J, Hill, Robert, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Liu, Bo, Richmond, Wendy, Sancho-Martinez, Ignacio, Phimister, Andrew, Seidel, H. Martin, Badman, Michael K, Joseph, Sean B, Laffitte, Bryan, Molteni, Valentina

“…Farnesoid X receptor (FXR) agonists are emerging as important potential therapeutics for the treatment of nonalcoholic steatohepatitis (NASH) patients, as they…”
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Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice by Yu, Xing Xian, Murray, Susan F, Pandey, Sanjay K, Booten, Sheri L, Bao, Dingjiu, Song, Xiu-Zhen, Kelly, Susan, Chen, Songyuan, McKay, Robert, Monia, Brett P, Bhanot, Sanjay

“…In this study, we investigated the role of acyl-coenzyme A:diacylglycerol acyltransferase 2 (DGAT2) in glucose and lipid metabolism in obese mice by reducing…”
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Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists by Azimioara, Mihai, Alper, Phil, Cow, Christopher, Mutnick, Daniel, Nikulin, Victor, Lelais, Gerald, Mecom, John, McNeill, Matthew, Michellys, Pierre-Yves, Wang, Zhiliang, Reding, Esther, Paliotti, Michael, Li, Jing, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Zimmerman, Matthew, Groessl, Todd, Tuntland, Tove, Joseph, Sean B., McNamara, Peter, Seidel, H. Martin, Epple, Robert

“…[Display omitted] Systematic SAR optimization of the GPR119 agonist lead 1, derived from an internal HTS campaign, led to compound 29. Compound 29 displays…”
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Discovery of structurally novel, potent and orally efficacious GPR119 agonists by Alper, Phil, Azimioara, Mihai, Cow, Christopher, Mutnick, Daniel, Nikulin, Victor, Michellys, Pierre-Yves, Wang, Zhiliang, Reding, Esther, Paliotti, Michael, Li, Jing, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Zimmerman, Matthew, Groessel, Todd, Tuntland, Tove, Joseph, Sean B., McNamara, Peter, Seidel, H. Martin, Epple, Robert

“…Screening hit 5 was identified in a biochemical screen for GPR119 agonists. Compound 5 was structurally novel, displayed modest biochemical activity and no…”
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Adenosine formed by 5'-nucleotidase mediates tubuloglomerular feedback by Thomson, S, Bao, D, Deng, A, Vallon, V

“…Nephron function is stabilized by tubuloglomerular feedback (TGF). TGF operates within the juxtaglomerular apparatus, sensing changes in tubular flow and…”
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Temporal adjustment of the juxtaglomerular apparatus during sustained inhibition of proximal reabsorption by Thomson, S C, Bachmann, S, Bostanjoglo, M, Ecelbarger, C A, Peterson, O W, Schwartz, D, Bao, D, Blantz, R C

“…Tubuloglomerular feedback (TGF) stabilizes nephron function by causing changes in single-nephron GFR (SNGFR) to compensate for changes in late proximal flow…”
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