Search Results - "Bantscheff, Marcus"

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP by Sridharan, Sindhuja, Kurzawa, Nils, Werner, Thilo, Günthner, Ina, Helm, Dominic, Huber, Wolfgang, Bantscheff, Marcus, Savitski, Mikhail M.

“…Adenosine triphosphate (ATP) plays fundamental roles in cellular biochemistry and was recently discovered to function as a biological hydrotrope. Here, we use…”
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A Scalable Approach for Protein False Discovery Rate Estimation in Large Proteomic Data Sets[S] by Savitski, Mikhail M., Wilhelm, Mathias, Hahne, Hannes, Kuster, Bernhard, Bantscheff, Marcus

“…Calculating the number of confidently identified proteins and estimating false discovery rate (FDR) is a challenge when analyzing very large proteomic data…”
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Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present by Bantscheff, Marcus, Lemeer, Simone, Savitski, Mikhail M., Kuster, Bernhard

“…Mass-spectrometry-based proteomics is continuing to make major contributions to the discovery of fundamental biological processes and, more recently, has also…”
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Quantitative mass spectrometry in proteomics: a critical review by Bantscheff, Marcus, Schirle, Markus, Sweetman, Gavain, Rick, Jens, Kuster, Bernhard

“…The quantification of differences between two or more physiological states of a biological system is among the most important but also most challenging…”
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Chemoproteomic approaches to drug target identification and drug profiling by Bantscheff, Marcus, Drewes, Gerard

“…Chemoproteomics represents a new research discipline at the interface of medicinal chemistry, biochemistry, and cell biology focused on studying the molecular…”
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Systematic analysis of protein turnover in primary cells by Mathieson, Toby, Franken, Holger, Kosinski, Jan, Kurzawa, Nils, Zinn, Nico, Sweetman, Gavain, Poeckel, Daniel, Ratnu, Vikram S., Schramm, Maike, Becher, Isabelle, Steidel, Michael, Noh, Kyung-Min, Bergamini, Giovanna, Beck, Martin, Bantscheff, Marcus, Savitski, Mikhail M.

“…A better understanding of proteostasis in health and disease requires robust methods to determine protein half-lives. Here we improve the precision and…”
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Mass-spectrometry-based draft of the Arabidopsis proteome by Mergner, Julia, Frejno, Martin, List, Markus, Papacek, Michael, Chen, Xia, Chaudhary, Ajeet, Samaras, Patroklos, Richter, Sandra, Shikata, Hiromasa, Messerer, Maxim, Lang, Daniel, Altmann, Stefan, Cyprys, Philipp, Zolg, Daniel P., Mathieson, Toby, Bantscheff, Marcus, Hazarika, Rashmi R., Schmidt, Tobias, Dawid, Corinna, Dunkel, Andreas, Hofmann, Thomas, Sprunck, Stefanie, Falter-Braun, Pascal, Johannes, Frank, Mayer, Klaus F. X., Jürgens, Gerd, Wilhelm, Mathias, Baumbach, Jan, Grill, Erwin, Schneitz, Kay, Schwechheimer, Claus, Kuster, Bernhard

“…Plants are essential for life and are extremely diverse organisms with unique molecular capabilities 1 . Here we present a quantitative atlas of the…”
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Mass-spectrometry-based draft of the human proteome by Wilhelm, Mathias, Schlegl, Judith, Hahne, Hannes, Gholami, Amin Moghaddas, Lieberenz, Marcus, Savitski, Mikhail M., Ziegler, Emanuel, Butzmann, Lars, Gessulat, Siegfried, Marx, Harald, Mathieson, Toby, Lemeer, Simone, Schnatbaum, Karsten, Reimer, Ulf, Wenschuh, Holger, Mollenhauer, Martin, Slotta-Huspenina, Julia, Boese, Joos-Hendrik, Bantscheff, Marcus, Gerstmair, Anja, Faerber, Franz, Kuster, Bernhard

“…Proteomes are characterized by large protein-abundance differences, cell-type- and time-dependent expression patterns and post-translational modifications, all…”
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A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles by Kurzawa, Nils, Becher, Isabelle, Sridharan, Sindhuja, Franken, Holger, Mateus, André, Anders, Simon, Bantscheff, Marcus, Huber, Wolfgang, Savitski, Mikhail M.

“…Detecting ligand-protein interactions in living cells is a fundamental challenge in molecular biology and drug research. Proteome-wide profiling of thermal…”
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Meltome atlas—thermal proteome stability across the tree of life by Jarzab, Anna, Kurzawa, Nils, Hopf, Thomas, Moerch, Matthias, Zecha, Jana, Leijten, Niels, Bian, Yangyang, Musiol, Eva, Maschberger, Melanie, Stoehr, Gabriele, Becher, Isabelle, Daly, Charlotte, Samaras, Patroklos, Mergner, Julia, Spanier, Britta, Angelov, Angel, Werner, Thilo, Bantscheff, Marcus, Wilhelm, Mathias, Klingenspor, Martin, Lemeer, Simone, Liebl, Wolfgang, Hahne, Hannes, Savitski, Mikhail M., Kuster, Bernhard

“…We have used a mass spectrometry-based proteomic approach to compile an atlas of the thermal stability of 48,000 proteins across 13 species ranging from…”
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Cell surface thermal proteome profiling tracks perturbations and drug targets on the plasma membrane by Kalxdorf, Mathias, Günthner, Ina, Becher, Isabelle, Kurzawa, Nils, Knecht, Sascha, Savitski, Mikhail M., Eberl, H. Christian, Bantscheff, Marcus

“…Numerous drugs and endogenous ligands bind to cell surface receptors leading to modulation of downstream signaling cascades and frequently to adaptation of the…”
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Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry by Franken, Holger, Mathieson, Toby, Childs, Dorothee, Sweetman, Gavain M A, Werner, Thilo, Tögel, Ina, Doce, Carola, Gade, Stephan, Bantscheff, Marcus, Drewes, Gerard, Reinhard, Friedrich B M, Huber, Wolfgang, Savitski, Mikhail M

“…Unbiased proteome-level discovery of intracellular drug targets can be achieved by plotting melting curves of proteins from untreated and drug-treated cells…”
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Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation by Gilan, Omer, Rioja, Inmaculada, Knezevic, Kathy, Bell, Matthew J, Yeung, Miriam M, Harker, Nicola R, Lam, Enid Y N, Chung, Chun-Wa, Bamborough, Paul, Petretich, Massimo, Urh, Marjeta, Atkinson, Stephen J, Bassil, Anna K, Roberts, Emma J, Vassiliadis, Dane, Burr, Marian L, Preston, Alex G S, Wellaway, Christopher, Werner, Thilo, Gray, James R, Michon, Anne-Marie, Gobbetti, Thomas, Kumar, Vinod, Soden, Peter E, Haynes, Andrea, Vappiani, Johanna, Tough, David F, Taylor, Simon, Dawson, Sarah-Jane, Bantscheff, Marcus, Lindon, Matthew, Drewes, Gerard, Demont, Emmanuel H, Daniels, Danette L, Grandi, Paola, Prinjha, Rab K, Dawson, Mark A

“…The two tandem bromodomains of the BET (bromodomain and extraterminal domain) proteins enable chromatin binding to facilitate transcription. Drugs that inhibit…”
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Tracking cancer drugs in living cells by thermal profiling of the proteome by Savitski, Mikhail M., Reinhard, Friedrich B. M., Franken, Holger, Werner, Thilo, Savitski, Maria Fälth, Eberhard, Dirk, Molina, Daniel Martinez, Jafari, Rozbeh, Dovega, Rebecca Bakszt, Klaeger, Susan, Kuster, Bernhard, Nordlund, Pär, Bantscheff, Marcus, Drewes, Gerard

“…The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by determining the thermal profiles of…”
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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition by Frost, Julianty, Galdeano, Carles, Soares, Pedro, Gadd, Morgan S., Grzes, Katarzyna M., Ellis, Lucy, Epemolu, Ola, Shimamura, Satoko, Bantscheff, Marcus, Grandi, Paola, Read, Kevin D., Cantrell, Doreen A., Rocha, Sonia, Ciulli, Alessio

“…Chemical strategies to using small molecules to stimulate hypoxia inducible factors (HIFs) activity and trigger a hypoxic response under normoxic conditions,…”
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Identifying drug targets in tissues and whole blood with thermal-shift profiling by Perrin, Jessica, Werner, Thilo, Kurzawa, Nils, Rutkowska, Anna, Childs, Dorothee D., Kalxdorf, Mathias, Poeckel, Daniel, Stonehouse, Eugenia, Strohmer, Katrin, Heller, Bianca, Thomson, Douglas W., Krause, Jana, Becher, Isabelle, Eberl, H. Christian, Vappiani, Johanna, Sevin, Daniel C., Rau, Christina E., Franken, Holger, Huber, Wolfgang, Faelth-Savitski, Maria, Savitski, Mikhail M., Bantscheff, Marcus, Bergamini, Giovanna

“…Monitoring drug–target interactions with methods such as the cellular thermal-shift assay (CETSA) is well established for simple cell systems but remains…”
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Confident Phosphorylation Site Localization Using the Mascot Delta Score by Savitski, Mikhail M., Lemeer, Simone, Boesche, Markus, Lang, Manja, Mathieson, Toby, Bantscheff, Marcus, Kuster, Bernhard

“…Large scale phosphorylation analysis is more and more getting into focus of proteomic research. Although it is now possible to identify thousands of…”
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Mass spectrometry-based chemoproteomic approaches by Bantscheff, Marcus

“…The term "chemical proteomics" refers to a research area at the interface of chemistry, biochemistry, and cell biology that focuses on studying the mechanism…”
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PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding by Tinworth, Christopher P, Lithgow, Hannah, Dittus, Lars, Bassi, Zuni I, Hughes, Sophie E, Muelbaier, Marcel, Dai, Han, Smith, Ian E. D, Kerr, William J, Burley, Glenn A, Bantscheff, Marcus, Harling, John D

“…The impact of covalent binding on PROTAC-mediated degradation of BTK was investigated through the preparation of both covalent binding and reversible binding…”
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Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2 by Mares, Alina, Miah, Afjal H., Smith, Ian E. D., Rackham, Mark, Thawani, Aditya R., Cryan, Jenni, Haile, Pamela A., Votta, Bartholomew J., Beal, Allison M., Capriotti, Carol, Reilly, Michael A., Fisher, Don T., Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T., Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B., Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, Harling, John D.

“…Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules that can promote the rapid and selective proteasome-mediated degradation of…”
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