Search Results - "Banton, Marcy I"

Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance by Cruzan, George, Bus, James S, Banton, Marcy I, Sarang, Satinder S, Waites, Robbie, Layko, Debra B, Raymond, James, Dodd, Darol, Andersen, Melvin E

“…Styrene is a mouse-specific lung carcinogen, and short-term mode of action studies have demonstrated that cytotoxicity and/or cell proliferation, and genomic…”
Get full text

Physiologically based pharmacokinetic model for ethyl tertiary‐butyl ether and tertiary‐butyl alcohol in rats: Contribution of binding to α2u–globulin in male rats and high‐exposure nonlinear kinetics to toxicity and cancer outcomes by Borghoff, Susan J., Ring, Caroline, Banton, Marcy I., Leavens, Teresa L.

“…In cancer bioassays, inhalation, but not drinking water exposure to ethyl tertiary‐butyl ether (ETBE), caused liver tumors in male rats, while tertiary‐butyl…”
Get full text

A toxicological review of the propylene glycols by Fowles, Jeff R., Banton, Marcy I., Pottenger, Lynn H.

“…Abstract The toxicological profiles of monopropylene glycol (MPG), dipropylene glycol (DPG), tripropylene glycol (TPG) and polypropylene glycols (PPG;…”
Get full text

Corrigendum to “Histopathology re-examination of the NTP toxicity/carcinogenicity studies of tert-butyl alcohol to identify renal tumor and toxicity modes of action” [Regul. Toxicol. Pharmacol. 102 (2019) 65–73] by Hard, Gordon C., Cohen, Samuel M., Ma, Jihyun, Yu, Fang, Arnold, Lora L., Banton, Marcy I.

Get full text

Based on an analysis of mode of action, styrene-induced mouse lung tumors are not a human cancer concern by Cruzan, George, Bus, James S., Andersen, Melvin E., Carlson, Gary P., Banton, Marcy I., Sarang, Satinder S., Waites, Robbie

“…Based on 13 chronic studies, styrene exposure causes lung tumors in mice, but no tumor increases in other organs in mice or rats. Extensive research into the…”
Get full text

Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures by Andersen, Melvin E., Cruzan, George, Black, Michael B., Pendse, Salil N., Dodd, Darol, Bus, James S., Sarang, Satinder S., Banton, Marcy I., Waites, Robbie, McMullen, Patrick D.

“…Styrene increased lung tumors in mice at chronic inhalation exposures of 20ppm and greater. MIEs, KEs and MFs were examined using gene expression in three…”
Get full text

Histopathology re-examination of the NTP toxicity/carcinogenicity studies of tert-butyl alcohol to identify renal tumor and toxicity modes of action by Hard, Gordon C., Cohen, Samuel M., Ma, Jihyun, Yu, Fang, Arnold, Lora L., Banton, Marcy I.

“…Tert-butyl alcohol (TBA) targets the rat kidney following repeated exposures, including renal tubule tumors. The mode of action (MOA) of these tumors,…”
Get full text

Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to alpha 2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes by Borghoff, Susan J, Ring, Caroline, Banton, Marcy I, Leavens, Teresa L

“…In cancer bioassays, inhalation, but not drinking water exposure to ethyl tertiary-butyl ether (ETBE), caused liver tumors in male rats, while tertiary-butyl…”
Get full text

Assessment of petroleum streams for thyroid toxicity by Fowles, Jeff R., Banton, Marcy I., Boogaard, Peter J., Ketelslegers, Hans B., Rohde, Arlean M.

“…•19 petroleum streams were assessed for thyroid effects, from 349 animal studies.•3 studies found effects related to thyroid toxicity, related to high aromatic…”
Get full text

Consideration of rat chronic progressive nephropathy in regulatory evaluations for carcinogenicity by Hard, Gordon C, Banton, Marcy I, Bretzlaff, Robert S, Dekant, Wolfgang, Fowles, Jefferson R, Mallett, Anthony K, McGregor, Douglas B, Roberts, Kathleen M, Sielken, Jr, Robert L, Valdez-Flores, Ciriaco, Cohen, Samuel M

“…Chronic progressive nephropathy (CPN) is a spontaneous renal disease of rats which can be a serious confounder in toxicology studies. It is a progressive…”
Get full text

Human health assessment for long-term oral ingestion of diethylene glycol by Snellings, William M., McMartin, Kenneth E., Banton, Marcy I., Reitman, Fred, Klapacz, Joanna

“…Diethylene glycol (DEG) is an organic chemical that is used mostly as a chemical intermediate and has minor uses as a solvent or antifreeze in consumer…”
Get full text

Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment by Andersen, Melvin E., Cruzan, George, Black, Michael B., Pendse, Salil N., Dodd, Darol E., Bus, James S., Sarang, Satinder S., Banton, Marcy I., Waites, Robbie, Layko, Debra B., McMullen, Patrick D.

“…Both CD-1 and C57BL/6 wildtype (C57BL/6-WT) mice show equivalent short-term lung toxicity from exposures to styrene, while long-term tumor responses are…”
Get full text

Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4) by Sweeney, Lisa M., Kester, Janet E., Kirman, Christopher R., Gentry, P. Robinan, Banton, Marcy I., Bus, James S., Gargas, Michael L.

“…Potential chronic health risks for children and prospective parents exposed to ethylbenzene were evaluated in response to the Voluntary Children's Chemical…”
Get full text

Dermal penetration of propylene glycols: Measured absorption across human abdominal skin in vitro and comparison with a QSAR model by Fasano, William J., ten Berge, Wil F., Banton, Marcy I., Heneweer, Marjoke, Moore, Nigel P.

“…► Dermal penetration of propylene glycols measured in vitro is compared with a QSAR model. ► The measured Jss and Kp for MPG were 97.6μg/cm2/h and…”
Get full text

Human health screening level risk assessments of tertiary-butyl acetate (TBAC): Calculated acute and chronic reference concentration (RfC) and Hazard Quotient (HQ) values based on toxicity and exposure scenario evaluations by Bus, James S., Banton, Marcy I., Faber, Willem D., Kirman, Christopher R., McGregor, Douglas B., Pourreau, Daniel B.

“…Abstract A screening level risk assessment has been performed for tertiary-butyl acetate (TBAC) examining its primary uses as a solvent in industrial and…”
Get full text

Acute inhalation study of allyl alcohol for derivation of acute exposure guideline levels by Li, Abby A., Fowles, Jefferson, Banton, Marcy I., Picut, Catherine, Kirkpatrick, Daniel T.

“…An acute, whole-body inhalation study for allyl alcohol in Sprague-Dawley rats was designed to support derivation of AEGL values, with emphasis on establishing…”
Get full text

Biodegradability relationships among propylene glycol substances in the organization for Economic Cooperation and Development ready- and seawater biodegradability tests by West, Robert J., Davis, John W., Pottenger, Lynn H., Banton, Marcy I., Graham, Cynthia

“…Eight propylene glycol substances, ranging from 1,2‐propanediol to a poly(propylene glycol) (PPG) having number‐average molecular weight (Mn) of 2,700 (i.e.,…”
Get full text

A consistent and transparent approach for calculation of Derived No-Effect Levels (DNELs) for petroleum substances by Boogaard, Peter J., Banton, Marcy I., Dalbey, Walden, Hedelin, Anna S., Riley, Anthony J., Rushton, Erik K., Vaissière, Mathieu, Minsavage, Gary D.

“…► Calculation of DNEL values for petroleum substances. ► Informed Assessment Factors based on petroleum substance specific information. ► Comparison of DNEL…”
Get full text

ECETOC workshop on the biological significance of DNA adducts: Summary of follow-up from an Expert Panel Meeting by Pottenger, Lynn H., Carmichael, Neil, Banton, Marcy I., Boogaard, Peter J., Kim, James, Kirkland, David, Phillips, Richard D., van Benthem, Jan, Williams, Gary M., Castrovinci, Alexis

“…This workshop on the biological significance of DNA adducts included presentations of research results in the following areas: endogenous versus exogenous…”
Get full text

Oral subchronic immunotoxicity study of ethyl tertiary butyl ether in the rat by Banton, Marcy I, Peachee, Vanessa L, White, Kimber L, Padgett, Eric L

“…The potential for immunotoxicological effects of ethyl tertiary butyl ether (ETBE, CAS RN 637-92-3) was studied in young adult female Crl:CD(SD) rats following…”
Get more information