Search Results - "Bannoura, Sahar"

Targeting KRAS in pancreatic cancer: new drugs on the horizon by Bannoura, Sahar F., Uddin, Md. Hafiz, Nagasaka, Misako, Fazili, Farzeen, Al-Hallak, Mohammed Najeeb, Philip, Philip A., El-Rayes, Bassel, Azmi, Asfar S.

“…Kirsten Rat Sarcoma (KRAS) is a master oncogene involved in cellular proliferation and survival and is the most commonly mutated oncogene in all cancers…”
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KRAS G12D targeted therapies for pancreatic cancer: Has the fortress been conquered? by Bannoura, Sahar F, Khan, Husain Yar, Azmi, Asfar S

“…KRAS mutations are among the most commonly occurring mutations in cancer. After being deemed undruggable for decades, KRAS G12C specific inhibitors showed that…”
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RCC1 regulation of subcellular protein localization via Ran GTPase drives pancreatic ductal adenocarcinoma growth by Bannoura, Sahar F., Aboukameel, Amro, Khan, Husain Yar, Uddin, Md Hafiz, Jang, Hyejeong, Beal, Eliza W, Thangasamy, Amalraj, Shi, Yang, Kim, Seongho, Wagner, Kay-Uwe, Beydoun, Rafic, El-Rayes, Bassel F., Philip, Philip A., Mohammad, Ramzi M., Saif, Muhammad Wasif, Al-Hallak, Mohammed Najeeb, Pasche, Boris C., Azmi, Asfar S.

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy, with limited therapeutic options. Here, we evaluated the role of regulator of chromosome…”
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Targeting guanine nucleotide exchange factors for novel cancer drug discovery by Bannoura, Sahar F, Khan, Husain Yar, Uddin, Md Hafiz, Mohammad, Ramzi M, Pasche, Boris C, Azmi, Asfar S

“…Guanine nucleotide exchange factors (GEFs) regulate the activation of small GTPases (G proteins) of the Ras superfamily proteins controlling cellular…”
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Anticancer Efficacy of KRASG12C Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of KRASG12C-Mutant Pancreatic and Lung Cancers by Khan, Husain Yar, Nagasaka, Misako, Aboukameel, Amro, Alkhalili, Osama, Uddin, Md Hafiz, Bannoura, Sahar F, Mzannar, Yousef, Azar, Ibrahim, Beal, Eliza W, Tobon, Miguel E, Kim, Steve H, Beydoun, Rafic, Baloglu, Erkan, Senapedis, William, El-Rayes, Bassel F, Philip, Philip A, Mohammad, Ramzi M, Shields, Anthony F, Al Hallak, Mohammed Najeeb, Azmi, Asfar S

“…KRASG12C inhibitors, such as sotorasib and adagrasib, have revolutionized cancer treatment for patients with KRASG12C-mutant tumors. However, patients…”
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Molecular analysis of XPO1 inhibitor and gemcitabine–nab‐paclitaxel combination in KPC pancreatic cancer mouse model by Uddin, Md. Hafiz, Al‐Hallak, Mohammad Najeeb, Khan, Husain Yar, Aboukameel, Amro, Li, Yiwei, Bannoura, Sahar F., Dyson, Gregory, Kim, Seongho, Mzannar, Yosef, Azar, Ibrahim, Odisho, Tanya, Mohamed, Amr, Landesman, Yosef, Kim, Steve, Beydoun, Rafic, Mohammad, Ramzi M., Philip, Philip A., Shields, Anthony F., Azmi, Asfar S.

“…Background The majority of pancreatic ductal adenocarcinoma (PDAC) patients experience disease progression while on treatment with gemcitabine and nanoparticle…”
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Targeting Cellular Metabolism With CPI-613 Sensitizes Pancreatic Cancer Cells to Radiation Therapy by Khan, Husain Yar, Kamgar, Mandana, Aboukameel, Amro, Bannoura, Sahar, Chung, Brian Y., Li, Yiwei, Hallak, Mohammed Najeeb Al, Philip, Philip A., Tsai, Susan, Luther, Sanjeev, Hall, William A., Azmi, Asfar S.

“…Local tumor progression is a cause of significant morbidity and mortality in patients with pancreatic ductal adenocarcinoma (PDAC) with surgically unresectable…”
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The Clinical Menin Inhibitor Ziftomenib and the Nuclear Export Inhibitor Selinexor Synergistically Inhibit the Growth of MLL-r AML by Uddin, Md. Hafiz, Aboukameel, Amro, Siddiqui, Sharif hasan, Khan, Husain, Bannoura, Sahar, Deol, Abhinav, Yang, Jay, Dyson, Gregory, Azmi, Asfar, Polin, Lisa, Maciejewski, Jaroslaw P., Balasubramanian, Suresh Kumar

“…Menin is a scaffold protein that interacts with oncogenic histone-lysine-N-methyltransferase MLL1 (KMT2A)-fusion protein (FP) complex in MLL-rearranged (…”
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361 SELINEXOR IN COMBINATION WITH GEMCITABINE-NAB-PACLITAXEL FOR PANCREATIC CANCER THERAPY by Bannoura, Sahar F., Uddin, Mohammed H., Aboukameel, Amro, Li, Yiwei, Mohammad, Ramzi M., Al-Hallak, Mohammed N., Philip, Philip A., Azmi, Asfar S.

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Novel Combination of Clinical Menin Inhibitor Ziftomenib and the Nuclear Export Inhibitor Selinexor Synergistically Inhibit MLL-r AML by Uddin, Md. Hafiz, Aboukameel, Amro, Khan, Husain, Bannoura, Sahar, Li, Yiwei, Deol, Abhinav, Yang, Jay, Azmi, Asfar Sohail, Maciejewski, Jaroslaw P., Balasubramanian, Suresh Kumar

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Tu1208 REGULATING THE REGULATOR: REGULATOR OF CHROMOSOME CONDENSATION 1 (RCC1) AS A NOVEL THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA by Bannoura, Sahar F., Khan, Husain Y., Aboukameel, Amro, Uddin, Mohammed H., Nimri, Rund, Kim, Seongho, Beal, Eliza, Al-Hallak, Mohammed N., El-Rayes, Bassel, Mohammad, Ramzi M., Azmi, Asfar S.

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Multi-omic characterization of RCC1 expression and its association with molecular alterations, immune phenotypes, and cancer outcomes by Warnecke, Brian, Nagasaka, Misako, Al Hallak, Mohammed Najeeb, Bannoura, Sahar, Kim, Chul, Elliott, Andrew, Halmos, Balazs, Hoon, Dave S., Darabi, Sourat, Farrell, Alex Patrick, Sukari, Ammar, Radovich, Milan, Lou, Emil, Sledge, George W., El-Deiry, Wafik S., Azmi, Asfar S.

“…3128 Background: Regulator of Chromosome Condensation 1 (RCC1) is the only identified guanine nucleotide exchange factor for the Ras-related nuclear protein…”
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Connecting the Human Microbiome and Pancreatic Cancer by Sexton, Rachel E., Uddin, Md Hafiz, Bannoura, Sahar, Khan, Husain Yar, Mzannar, Yousef, Li, Yiwei, Aboukameel, Amro, Al-Hallak, Mohammad Najeeb, Al-Share, Bayan, Mohamed, Amr, Nagasaka, Misako, El-Rayes, Bassel, Azmi, Asfar S.

“…Pancreatic cancer is a deadly disease that is increasing in incidence throughout the world. There are no clear causal factors associated with the incidence of…”
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Correction to: Connecting the human microbiome and pancreatic cancer by Sexton, Rachel E., Uddin, Md Hafz, Bannoura, Sahar, Khan, Husain Yar, Mzannar, Yousef, Li, Yiwei, Aboukameel, Amro, Al-Hallak, Mohammad Najeeb, Al-Share, Bayan, Mohamed, Amr, Nagasaka, Misako, El-Rayes, Bassel, Azmi, Asfar S.

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A phase I study of CPI-613 (devimistat) in combination with chemoradiation in patients with pancreatic adenocarcinoma by Kamgar, Mandana, Khan, Husain Yar, Aboukameel, Amro, Bannoura, Sahar, Chung, Brian Y., Szabo, Aniko, Li, Yiwei, Al Hallak, Mohammed Najeeb, Philip, Philip Agop, George, Ben, Christians, Kathleen K., Evans, Douglas B., Tsai, Susan, Erickson, Beth, Luther, Sanjeev, Azmi, Asfar S., Hall, William A.

“…TPS760 Background: Local tumor progression is a cause of significant mortality and morbidity in patients with unresectable pancreatic ductal adenocarcinoma…”
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Abstract 5587: Regulator of chromosome condensation 1 (RCC1) as a novel therapeutic target in pancreatic ductal adenocarcinoma by Bannoura, Sahar F., Khan, Husain Y., Aboukameel, Amro, Uddin, Md Hafiz, Nimri, Rund, Beal, Eliza, Kim, Seongho, Hallak, Mohammed Najeeb Al, El-Rayes, Bassel, Philip, Philip A., Pasche, Boris, Mohammad, Ramzi, Azmi, Asfar S.

“…Abstract Background and Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with limited treatment options. There is an urgent…”
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Abstract 4530: Nuclear export inhibitor cooperates with PARP inhibitor to suppress the growth of metastatic castration resistant prostate cancer in vivo by Uddin, Md Hafiz, Aboukameel, Amro, Khan, Husain Y., Bannoura, Sahar F., Cackowski, Frank, Beydoun, Rafic, Dyson, Gregory, Kim, Seongho, Boerner, Julie, Shidham, Vinod, Mohammad, Ramzi M., Pasche, Boris C., Azmi, Asfar S., Heath, Elisabeth I.

“…Abstract Background: Aberrant nuclear protein transport, often observed in cancer, causes mislocalization-dependent inactivation of critical cellular proteins…”
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Inhibitor of the Nuclear Transport Protein XPO1 Enhances the Anticancer Efficacy of KRAS G12C Inhibitors in Preclinical Models of KRAS G12C-Mutant Cancers by Khan, Husain Yar, Nagasaka, Misako, Li, Yiwei, Aboukameel, Amro, Uddin, Md Hafiz, Sexton, Rachel, Bannoura, Sahar, Mzannar, Yousef, Al-Hallak, Mohammed Najeeb, Kim, Steve, Beydoun, Rafic, Landesman, Yosef, Mamdani, Hirva, Uprety, Dipesh, Philip, Philip A, Mohammad, Ramzi M, Shields, Anthony F, Azmi, Asfar S

“…The identification of molecules that can bind covalently to KRAS G12C and lock it in an inactive GDP-bound conformation has opened the door to targeting KRAS…”
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Abstract CT080: A phase I study of CPI-613 (devimistat) in combination with chemoradiation in patients with pancreatic ductal adenocarcinoma by Kamgar, Mandana, Khan, Husain Yar, Aboukameel, Amro, Bannoura, Sahar F., Chung, Brian Y., Szabo, Aniko, Li, Yiwei, Hallak, Mohammed Najeeb Al, Philip, Philip A., George, Ben, Christians, Kathleen K., Evans, Douglas B., Tsai, Susan, Erickson, Beth, Goldberg, John M., Azmi, Asfar S., Hall, William A.

“…Abstract Background: Local tumor progression is a cause of significant mortality and morbidity in patients (pts) with inoperable pancreatic ductal…”
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Abstract 4574: Next generation nuclear export blocker KPT8602 synergizes with KRASG12D inhibitor MRTX1133 resulting in improved antitumor effects against pancreatic ductal adenocarcinoma by Khan, Husain Yar, Aboukameel, Amro, Uddin, Md Hafiz, Bannoura, Sahar F., Keffri, Khaled, Jasti, Medha, Virga, Rachael, Motorwala, Sarah, Choucair, Khalil, Hadid, Tarik, Al-Hallak, Mohammad Najeeb, Beal, Eliza, Tobon, Miguel, Beydoun, Rafic, Dyson, Greg, Kim, Steve, Nagasaka, Misako, Philip, Philip A., El-Rayes, Basel, Chen, Herbert, Shields, Anthony, Mohammad, Ramzi, Pasche, Boris, Azmi, Asfar

“…Abstract Introduction: A novel KRAS inhibitor, MRTX1133, specifically targeting the G12D isoform, prevalent in pancreatic ductal adenocarcinoma (PDAC), holds…”
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