Search Results - "Bankert, RB"

Human–SCID mouse chimeric models for the evaluation of anti-cancer therapies by Bankert, Richard B, Egilmez, Nejat K, Hess, Stephen D

“…The ability to engraft human tumors and human immunocompetent cells successfully in severe combined immunodeficient (SCID) mice has spawned the development and…”
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THE NEXT GENERATION OF LIPOSOME DELIVERY SYSTEMS: RECENT EXPERIENCE WITH TUMOR-TARGETED, STERICALLY-STABILIZED IMMUNOLIPOSOMES AND ACTIVE-LOADING GRADIENTS by Abra, R. M., Bankert, R. B., Chen, F., Egilmez, N. K., Huang, K., Saville, R., Slater, J. L., Sugano, M., Yokota, S. J.

“…ABSTRACT Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-β1 integrin…”
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IL-12/TGF-[beta]1 Regulation of TCR Signal Transduction in Human Memory T Cells Associated with Malignant and Non-malignant Chronic Inflammatory Microenvironments by Broderick, L, Bankert, RB

“…Effector memory T cells were isolated from the primary, human, non-small cell lung tumors, nasal polyps and synovial fluid of rheumatic joints and evaluated…”
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Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres: Coinduction of innate and adaptive antitumor immunity and cure of disseminated disease by HILL, Hank C, CONWAY, Thomas F, SABEL, Michael S, JONG, Yong S, MATHIOWITZ, Edith, BANKERT, Richard B, EGILMEZ, Nejat K

“…Tumor cells, injected s.c., were maintained until spontaneous metastases to the lungs were established in all of the mice. Mice were then treated with a single…”
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Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells by Broderick, Lori, Yokota, Sandra J, Reineke, Joshua, Mathiowitz, Edith, Stewart, Carleton C, Barcos, Maurice, Kelleher, Jr, Raymond J, Bankert, Richard B

“…The implantation of small pieces of human primary lung tumor biopsy tissue into SCID mice results in a viable s.c. xenograft in which the tissue architecture,…”
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T Cells in Nasal Polyposis Demonstrate Hyporesponsiveness to Signaling through the T cell Receptor by Lehman, H.K, Bernstein, J.M, Bankert, R.B

“…Upregulation of CD107a surface expression, another T-cell activation endpoint, was decreased in polyp-associated CD8+ T cells following stimulation compared to…”
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In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres : Induction of tumor regression and potent antitumor immunity by EGILMEZ, N. K, JONG, Y. S, SABEL, M. S, JACOB, J. S, MATHIOWITZ, E, BANKERT, R. B

“…An alternative technology for the local and sustained delivery of cytokines to tumors for cancer immunotherapy was evaluated and shown here to induce tumor…”
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Human CD4+ T cells present within the microenvironment of human lung tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-gamma by Hess, Stephen D, Egilmez, Nejat K, Bailey, Nicola, Anderson, Timothy M, Mathiowitz, Edith, Bernstein, Steven H, Bankert, Richard B

“…By implanting nondisrupted pieces of human lung tumor biopsy tissues into SCID mice, it has been possible to establish viable grafts of the tumor, as well as…”
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IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells by Broderick, Lori, Brooks, Stephen P., Takita, Hiroshi, Baer, Alan N., Bernstein, Joel M., Bankert, Richard B.

“…Memory T cells in human non-small cell lung cancer are unresponsive to progressing tumors. T cells were evaluated at the single cell level by imaging the…”
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Antibody targeting of doxorubicin-loaded liposomes suppresses the growth and metastatic spread of established human lung tumor xenografts in severe combined immunodeficient mice by SUGANO, Masahiko, EGILMEZ, Nejat K, YOKOTA, Sandra J, CHEN, Fang-An, HARDING, Jennifer, SHI KUN HUANG, BANKERT, Richard B

“…Beta1 integrins, expressed on the cell surface of human non-small cell lung carcinomas, are used here as a target for the selective delivery of anti-cancer…”
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CTLA-4 blockade augments human T lymphocyte-mediated suppression of lung tumor xenografts in SCID mice by SABEL, Michael S, HESS, Stephen D, EGILMEZ, Nejat K, CONWAY, Thomas F, CHEN, Fang-An, BANKERT, Richard B

“…Previous studies by others using transplantable murine tumor models have demonstrated that the administration of antibodies that block CTLA-4 interaction with…”
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Human CD4+ effector T cells mediate indirect interleukin-12- and interferon-γ-dependent suppression of autologous HLA-negative lung tumor xenografts in severe combined immunodeficient mice by EGILMEZ, Nejat K, HESS, Stephen D, CHEN, Fang-An, TAKITA, Hiroshi, CONWAY, Thomas F, BANKERT, Richard B

“…A human/severe combined immunodeficient mouse chimeric model was used to demonstrate that peripheral blood leukocytes (PBLs) from a patient with lung cancer…”
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Evaluation and optimization of different cationic liposome formulations for in vivo gene transfer by Egilmez, N K, Iwanuma, Y, Bankert, R B

“…Five commonly used cationic liposome formulations were tested for their ability to deliver DNA to established subcutaneous human tumor xenografts in SCID mice…”
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CD40 expression on human lung cancer correlates with metastatic spread by SABEL, M. S, YAMADA, M, KAWAGUCHI, Y, CHEN, F.-A, TAKITA, H, BANKERT, R. B

“…The poor prognosis associated with lung cancer is related to the high incidence of regional and distant metastasis. There is a crucial need to identify…”
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Human Nasal Polyp Microenvironment Maintained in Viable and Functional States as Xenografts in SCID Mice by Bernstein, Joel M., Broderick, Lori, Parsons, Robert R., Bankert, Richard B.

“…Objectives: We undertook to maintain human nasal polyp tissue in a viable and functional state in SCID (severe combined immunodeficiency) mice. Methods: Small,…”
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Neoadjuvant therapy with interleukin-12-loaded polylactic acid microspheres reduces local recurrence and distant metastases by Sabel, Michael S., Hill, Hank, Jong, Yong S., Mathiowitz, Edith, Bankert, Richard B., Egilmez, Nejat K.

“…We previously demonstrated that the intratumoral injection of biodegradable polylactic acid microspheres that were loaded with interleukin (IL)-12 can induce a…”
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CD40‐CD40 ligand (CD154) engagement is required but not sufficient for modulating MHC class I, ICAM‐1 and Fas expression and proliferation of human non‐small cell lung tumors by Yamada, Makoto, Shiroko, Takashi, Kawaguchi, Yoshihiro, Sugiyama, Yasuyuki, Egilmez, Nejat K., Chen, Fang‐An, Bankert, Richard B.

“…To determine the possible functional significance of CD40 expression on human non‐small cell lung carcinomas and to assess the potential of CD40 as a…”
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Antitumor immune response of human peripheral blood lymphocytes coengrafted with tumor into severe combined immunodeficient mice by IWANUMA, Y, CHEN, F.-A, EGILMEZ, N. K, TAKITA, H, BANKERT, R. B

“…Here, it is established that human peripheral blood lymphocytes (HuPBLs), injected s.c. with a human lung tumor into severe combined immunodeficient (SCID)…”
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B cell tumor vaccine enhanced by covalent attachment of immunoglobulin to surface proteins on dendritic cells by Lou, Qiang, Conway, Thomas F., Egilmez, Nejat K., Loyall, Jenni L., Bernstein, Steven H., Kelleher, Raymond J., Bankert, Richard B.

“…Protein antigens have been covalently linked randomly to surface proteins on immature dendritic cells (DC). This has been achieved under physiological…”
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Arrest of human lung tumor xenograft growth in severe combined immunodeficient mice using doxorubicin encapsulated in sterically stabilized liposomes by WILLIAMS, S. S, ALOSCO, T. R, MAYHEW, E, LASIC, D. D, MARTIN, F. J, BANKERT, R. B

“…Incorporation of polyethylene glycol-derivatized phospholipids into liposomes results in carriers that can enhance the therapeutic efficacy of encapsulated…”
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