Search Results - "Bankaitis, Vytas A."

The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes by Grabon, Aby, Bankaitis, Vytas A., McDermott, Mark I.

“…Phosphoinositides are key regulators of a large number of diverse cellular processes that include membrane trafficking, plasma membrane receptor signaling,…”
Get full text

Inborn Errors of Long-Chain Fatty Acid β-Oxidation Link Neural Stem Cell Self-Renewal to Autism by Xie, Zhigang, Jones, Albert, Deeney, Jude T., Hur, Seong Kwon, Bankaitis, Vytas A.

“…Inborn errors of metabolism (IEMs) occur with high incidence in human populations. Especially prevalent among these are inborn deficiencies in fatty acid…”
Get full text

Lipoprotein Lipase Sorting: Sphingomyelin and a Proteoglycan Show the Way by Bankaitis, Vytas A., Wang, Yaxi

“…A mechanistic description for how soluble protein cargos are sorted into distinct vesicle classes at the level of the trans-Golgi network (TGN) has remained…”
Get full text

A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis by Xie, Zhigang, Hur, Seong Kwon, Zhao, Liang, Abrams, Charles S., Bankaitis, Vytas A.

“…Phosphatidylinositol (PtdIns) transfer proteins (PITPs) stimulate PtdIns-4-P synthesis and signaling in eukaryotic cells, but to what biological outcomes such…”
Get full text

The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling by Bankaitis, Vytas A., Mousley, Carl J., Schaaf, Gabriel

“…Lipid signaling pathways define central mechanisms for cellular regulation. Productive lipid signaling requires an orchestrated coupling between lipid…”
Get full text

Phosphoinositide phosphatases in cell biology and disease by Liu, Yang, Bankaitis, Vytas A.

“…Phosphoinositides are essential signaling molecules linked to a diverse array of cellular processes in eukaryotic cells. The metabolic interconversions of…”
Get full text

Unsaturated fatty acid-induced non-canonical autophagy: unusual? or unappreciated? by Bankaitis, Vytas A

“…The breakdown of cellular components via autophagy is crucial for cellular homeostasis. In this issue of The EMBO Journal , Niso‐Santano et al ( 2015 ) report…”
Get full text

Emerging Prospects for Combating Fungal Infections by Targeting Phosphatidylinositol Transfer Proteins by Khan, Danish, Nile, Aaron H., Tripathi, Ashutosh, Bankaitis, Vytas A.

“…The emergence of fungal “superbugs” resistant to the limited cohort of anti-fungal agents available to clinicians is eroding our ability to effectively treat…”
Get full text

Biophysical parameters of the Sec14 phospholipid exchange cycle – Effect of lipid packing in membranes by Sugiura, Taichi, Nakao, Hiroyuki, Ikeda, Keisuke, Khan, Danish, Nile, Aaron H., Bankaitis, Vytas A., Nakano, Minoru

“…Sec14, a yeast phosphatidylinositol/phosphatidylcholine transfer protein, functions at the trans-Golgi membranes. It lacks domains involved in protein-protein…”
Get full text

The Role of Phosphoinositides in Signaling and Disease: Introduction to the Thematic Review Series by Bankaitis, Vytas A., Carman, George M.

Get full text

Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase by Wang, Yaxi, Yuan, Peihua, Grabon, Aby, Tripathi, Ashutosh, Lee, Dongju, Rodriguez, Martin, Lönnfors, Max, Eisenberg-Bord, Michal, Wang, Zehua, Man Lam, Sin, Schuldiner, Maya, Bankaitis, Vytas A

“…The yeast phosphatidylserine (PtdSer) decarboxylase Psd2 is proposed to engage in a membrane contact site (MCS) for PtdSer decarboxylation to…”
Get full text

Biophysical Parameters of the Sec14 Phospholipid Exchange Cycle by Sugiura, Taichi, Takahashi, Chisato, Chuma, Yusuke, Fukuda, Masakazu, Yamada, Makiko, Yoshida, Ukyo, Nakao, Hiroyuki, Ikeda, Keisuke, Khan, Danish, Nile, Aaron H., Bankaitis, Vytas A., Nakano, Minoru

“…Sec14, the major yeast phosphatidylcholine (PC)/phosphatidylinositol (PI) transfer protein (PITP), coordinates PC and PI metabolism to facilitate an…”
Get full text

Regulation of phosphoinositide metabolism in Apicomplexan parasites by Arabiotorre, Angela, Bankaitis, Vytas A, Grabon, Aby

“…Phosphoinositides are a biologically essential class of phospholipids that contribute to organelle membrane identity, modulate membrane trafficking pathways,…”
Get full text

A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation by Chen, Xiao-Ru, Dixit, Karuna, Yang, Yuan, McDermott, Mark I, Imam, Hasan Tanvir, Bankaitis, Vytas A, Igumenova, Tatyana I

“…Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P defines a major eukaryotic pathway…”
Get full text

Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle by Grabon, Aby, Orłowski, Adam, Tripathi, Ashutosh, Vuorio, Joni, Javanainen, Matti, Róg, Tomasz, Lönnfors, Max, McDermott, Mark I., Siebert, Garland, Somerharju, Pentti, Vattulainen, Ilpo, Bankaitis, Vytas A.

“…Phosphatidylinositol-transfer proteins (PITPs) regulate phosphoinositide signaling in eukaryotic cells. The defining feature of PITPs is their ability to…”
Get full text

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction by Yeh, Yu-Te, Sona, Chandan, Yan, Xin, Li, Yunxiao, Pathak, Adrija, McDermott, Mark I., Xie, Zhigang, Liu, Liangwen, Arunagiri, Anoop, Wang, Yuting, Cazenave-Gassiot, Amaury, Ghosh, Adhideb, von Meyenn, Ferdinand, Kumarasamy, Sivarajan, Najjar, Sonia M., Jia, Shiqi, Wenk, Markus R., Traynor-Kaplan, Alexis, Arvan, Peter, Barg, Sebastian, Bankaitis, Vytas A., Poy, Matthew N.

“…Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer…”
Get full text

Diverse Sphingolipid Species Harbor Different Effects on Ire1 Clustering by Bieniawski, Mark A., Stevens, Kofi L. P., Witham, Christopher M., Steuart, Robert F. L., Bankaitis, Vytas A., Mousley, Carl J.

“…Endoplasmic reticulum (ER) function is dedicated to multiple essential processes in eukaryotes, including the processing of secretory proteins and the…”
Get full text

A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing by Mousley, Carl J., Yuan, Peihua, Gaur, Naseem A., Trettin, Kyle D., Nile, Aaron H., Deminoff, Stephen J., Dewar, Brian J., Wolpert, Max, Macdonald, Jeffrey M., Herman, Paul K., Hinnebusch, Alan G., Bankaitis, Vytas A.

“…Kes1, and other oxysterol-binding protein superfamily members, are involved in membrane and lipid trafficking through trans-Golgi network (TGN) and endosomal…”
Get full text

Functional Anatomy of Phospholipid Binding and Regulation of Phosphoinositide Homeostasis by Proteins of the Sec14 Superfamily by Schaaf, Gabriel, Ortlund, Eric A., Tyeryar, Kimberly R., Mousley, Carl J., Ile, Kristina E., Garrett, Teresa A., Ren, Jihui, Woolls, Melissa J., Raetz, Christian R.H., Redinbo, Matthew R., Bankaitis, Vytas A.

“…Sec14, the major yeast phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein, regulates essential interfaces between lipid metabolism and…”
Get full text

Phosphatidylinositol transfer proteins: Negotiating the regulatory interface between lipid metabolism and lipid signaling in diverse cellular processes by Ghosh, Ratna, Bankaitis, Vytas A.

“…Phosphoinositides represent only a small percentage of the total cellular lipid pool. Yet, these molecules play crucial roles in diverse intracellular…”
Get full text