Search Results - "Banitt, Lee S"

Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors by MILLER, Alita A, BUNDY, Gordon L, SWEENEY, Michael T, BAMMERT, Gary F, HAMEL, Judith C, FORD, Charles W, ZHONG, Wei-Zhu, GRABER, David R, MARTIN, Gary E, HAN, Fusen, DOLAK, Lester A, SEEST, Eric P, MOTT, John E, RUBLE, J. Craig, KAMILAR, Gregg M, PALMER, John R, BANITT, Lee S, HURD, Alexander R, BARBACHYN, Michael R, SKEPNER, Jill E, BOYLE, Timothy P, HARRIS, Douglas W, HROMOCKYJ, Alexander E, MAROTTI, Keith R, ZURENKO, Gary E, MUNZNER, Jennifer B

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Novel oxazolidinone–quinolone hybrid antimicrobials by Gordeev, Mikhail F., Hackbarth, Corinne, Barbachyn, Michael R., Banitt, Lee S., Gage, James R., Luehr, Gary W., Gomez, Marcela, Trias, Joaquim, Morin, Sara E., Zurenko, Gary E., Parker, Christian N., Evans, Jonathan M., White, Richard J., Patel, Dinesh V.

“…Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2,…”
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Chemical Oxidation of 2,4-Diamino-pyrrolo[2,3-d]pyrimidines by Bundy, Gordon L, Gremban, Robert S, Banitt, Lee S, Palmer, John R, Mizsak, Stephen A, Han, Fusen

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Preclinical evaluation of anti-inflammatory activities of the novel pyrrolopyrimidine PNU-142731A, a potential treatment for asthma by Chin, J E, Hatfield, C A, Winterrowd, G E, Krzesicki, R F, Shull, K L, Fidler, S F, Kolbasa, K P, Brashler, J R, Griffin, R L, Fleming, W E, Justen, J M, Banitt, L S, Bundy, G L, Richards, I M

“…The anti-inflammatory properties of a novel pyrrolopyrimidine, PNU-142731A, in a murine model of antigen-induced eosinophilic lung inflammation are described…”
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Synthesis of 2,4-Di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indoles, Including Antiasthma Clinical Candidate PNU-142731A by Bundy, Gordon L, Banitt, Lee S, Dobrowolski, Paul J, Palmer, John R, Schwartz, Theresa M, Zimmermann, David C, Lipton, Michael F, Mauragis, Michael A, Veley, Michael F, Appell, Robert B, Clouse, Robert C, Daugs, Edward D

“…Two syntheses are described for 1-[(2,4-di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indol-9-yl)-acetyl]pyrrolidine hydrochloride (PNU-142731A), a clinical candidate in…”
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Synthesis of Novel 2,4-Diaminopyrrolo[2,3-d]pyrimidines with Antioxidant, Neuroprotective, and Antiasthma Activity by Bundy, Gordon L, Ayer, Donald E, Banitt, Lee S, Belonga, Kenneth L, Mizsak, Stephen A, Palmer, John R, Tustin, James M, Chin, Jia En, Hall, Edward D

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Bioactivation of 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to Reactive Intermediates That Bind Covalently to Macromolecules and Produce Genotoxicity1 by Zhao, Zhiyang, Koeplinger, Kenneth A, Padbury, Guy E, Hauer, Michael J, Bundy, Gordon L, Banitt, Lee S, Schwartz, Theresa M, Zimmermann, David C, Harbach, Philip R, Mayo, Judy K, Aaron, C. Sidney

“…U-89843 is a novel pyrrolo[2,3-d]pyrimidine antioxidant with prophylactic activity in animal models of lung inflammation. During preclinical safety evaluation,…”
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Novel oxazolidinone-quinolone hybrid antimicrobials: Antibacterial agents: solutions for the evolving problems of resistance by GORDEEV, Mikhail F, HACKBARTH, Corinne, PARKER, Christian N, EVANS, Jonathan M, WHITE, Richard J, PATEL, Dinesh V, BARBACHYN, Michael R, BANITT, Lee S, GAGE, James R, LUEHR, Gary W, GOMEZ, Marcela, TRIAS, Joaquim, MORIN, Sara E, ZURENKO, Gary E

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Synthesis of 2,4-diaminopyrrolo[2,3-d]pyrimidines via thermal fischer indolization. Pyrazole formation with ytterbium triflate catalysis by Bundy, Gordon L., Schwartz, Theresa M., Palmer, John R., Banitt, Lee S., Watt, William

“…The high‐yield synthesis of the 2,4‐diaminopyrrolo[2,3‐d] pyrimidine 4 (PNU‐87663) via a Bischler‐like alkylation‐cyclization sequence was reported earlier. We…”
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Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity by Zhao, Z, Koeplinger, K A, Padbury, G E, Hauer, M J, Bundy, G L, Banitt, L S, Schwartz, T M, Zimmermann, D C, Harbach, P R, Mayo, J K, Aaron, C S

“…U-89843 is a novel pyrrolo[2,3-d]pyrimidine antioxidant with prophylactic activity in animal models of lung inflammation. During preclinical safety evaluation,…”
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Bioactivation of 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7 H -pyrrolo[2,3- d ]pyrimidine (U-89843) to Reactive Intermediates That Bind Covalently to Macromolecules and Produce Genotoxicity 1 by Zhao, Zhiyang, Koeplinger, Kenneth A., Padbury, Guy E., Hauer, Michael J., Bundy, Gordon L., Banitt, Lee S., Schwartz, Theresa M., Zimmermann, David C., Harbach, Philip R., Mayo, Judy K., Aaron, C. Sidney

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In vitro and in vivo biotransformation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-D]pyrimidine (U-89843) in the rat by Zhao, Z, Koeplinger, K A, Bundy, G L, Banitt, L S, Padbury, G E, Hauer, M J, Sanders, P E

“…The biotransformation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) has been studied in rat both in vitro and in vivo. Major…”
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