Search Results - "Banijamali, Ali R"

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease by Zimmer, Daniel P, Shea, Courtney M, Tobin, Jenny V, Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R, Jacobson, Sarah, Bernier, Sylvie G, Sarno, Renee, Carvalho, Andrew, Chien, Yueh-Tyng, Graul, Regina, Buys, Emmanuel S, Jones, Juli E, Wakefield, James D, Price, Gavrielle M, Chickering, Jennifer G, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L

“…Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth…”
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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats by Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.

“…The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a…”
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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease by Tobin, Jenny V, Zimmer, Daniel P, Shea, Courtney, Germano, Peter, Bernier, Sylvie G, Liu, Guang, Long, Kim, Miyashiro, Joy, Ranganath, Sheila, Jacobson, Sarah, Tang, Kim, Im, G-Yoon Jamie, Sheppeck, 2nd, James, Moore, Joel D, Sykes, Kristine, Wakefield, James, Sarno, Renee, Banijamali, Ali R, Profy, Albert T, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L

“…Soluble guanylate cyclase (sGC), a key signal-transduction enzyme, increases the conversion of guanosine-5'-triphosphate to cGMP upon binding of nitric oxide…”
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Metabolism and disposition of MM‐433593, a selective FAAH‐1 inhibitor, in monkeys by Banijamali, Ali R., Wakefield, James D., Mermerian, Ara H., Busby, Robert W.

“…MM‐433593 is a highly potent and selective inhibitor of fatty acid amide hydrolase‐1 (FAAH‐1) with potential utility as an orally administered treatment of…”
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The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model by Nikas, Spyros P, Grzybowska, Jolanta, Papahatjis, Demetris P, Charalambous, Avgui, Banijamali, Ali R, Chari, Ravi, Fan, Pusheng, Kourouli, Therapia, Lin, Sonyuan, Nitowski, Albert J, Marciniak, Gilbert, Guo, Yan, Li, Xiuyan, Wang, Chia-Lin J, Makriyannis, Alexandros

“…The presence of halogens within the classical cannabinoid structure leads to large variations in the compounds' potencies and affinities for the CB1 receptors…”
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mechanism for the formation of bis-glutathione conjugates of propargyl alcohol by Banijamali, Ali R, DeMatteo, Vincent, Sumner, Susan J

“…Our earlier research clearly revealed glutathione (GSH) conjugation as a major pathway for the metabolism of propargyl alcohol (2-propyn-1-ol) in rats and in…”
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Identification of Metabolites of [1,2,3-13C]Propargyl Alcohol in Mouse Urine by 13C NMR and Mass Spectrometry and Comparison to Rat by Banijamali, Ali R, Xu, Yaodong, DeMatteo, Vincent, Strunk, Richard J, Sumner, Susan J

“…Species differences in the metabolism of acetylenic compounds commonly used in the formulation of pharmaceuticals and pesticides have not been investigated. To…”
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Identification of Metabolites of [1,2,3-13C]Propargyl Alcohol in Rat Urine by 13C NMR and Mass Spectrometry by Banijamali, Ali R, Xu, Yaodong, Strunk, Richard J, Gay, Michael H, Ellis, Michael C, Putterman, Gerald J, Sumner, Susan J

“…Little is known about the metabolism of acetylenic (C⋮C) compounds commonly used in the formulation of pesticides. To better understand the in vivo reactivity…”
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Identification of [14C]quizalofop-P-tefuryl metabolites in goat urine by nuclear magnetic resonance and mass spectrometry by Banijamali, Ali R, Strunk, Richard J, Nag, Jayanta K, Putterman, Gerald J, Gay, Michael H

“…The urinary metabolites of [(14)C]quizalofop-P-tefuryl, (R,S)-tetrahydrofurfuryl (R)-2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]propanoate, were identified. A…”
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Structural characterization of [14C]propargite metabolites in goat urine by high-resolution FT-NMR and mass spectrometry by Banijamali, Ali R, Burger, Robert N, Nitowski, Albert J, Putterman, Gerald J

“…Urinary metabolites of [phenyl-U-14C]propargite, 2-[4-(1,1-dimethylethyl)phenoxy]cyclohexyl-2-propynyl sulfite, a nonsystemic acaricide, in a lactating goat…”
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Identification of Metabolites of [1,2,3- 13 C]Propargyl Alcohol in Mouse Urine by 13 C NMR and Mass Spectrometry and Comparison to Rat by Banijamali, Ali R., Xu, Yaodong, DeMatteo, Vincent, Strunk, Richard J., Sumner, Susan J.

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Identification of Metabolites of [1,2,3- 13 C]Propargyl Alcohol in Rat Urine by 13 C NMR and Mass Spectrometry by Banijamali, Ali R., Xu, Yaodong, Strunk, Richard J., Gay, Michael H., Ellis, Michael C., Putterman, Gerald J., Sumner, Susan J.

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Identification of metabolites of [1,2,3-(13)C]Propargyl alcohol in rat urine by (13)C NMR and mass spectrometry by Banijamali, A R, Xu, Y, Strunk, R J, Gay, M H, Ellis, M C, Putterman, G J, Sumner, S J

“…Little is known about the metabolism of acetylenic (C C) compounds commonly used in the formulation of pesticides. To better understand the in vivo reactivity…”
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Novel synthesis of (−)-trans-Δ9,11-tetrahydrocannabinol by Banijamali, Ali R., Makriyannis, Alexandros

“…Addition of hydrogen chloride gas to a solution of Δ8‐tetrahydrocannabinol in dry dichloromethane at ‐60° in the presence of zinc chloride results in the…”
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Addition and elimination of HCl to tetrahydrocannabinol isomers. A method for the preparation of stereospecifically 2H-labeled cannabinoids by Banijamali, Ali R., Van Der Schyf, Cornelis J., Makriyannis, Alexandros

“…Addition of HCl gas to (−)Δ8‐, (−)Δ9‐, or (−)Δ9,11‐THC solutions at −60°C results in the formation of 9α‐ and 9β‐chlorohexahydrocannabinol (Cl‐HHC). The…”
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Novel synthesis of (−)‐ trans ‐Δ 9,11 ‐tetrahydrocannabinol by Banijamali, Ali R., Makriyannis, Alexandros

“…Abstract Addition of hydrogen chloride gas to a solution of Δ 8 ‐tetrahydrocannabinol in dry dichloromethane at ‐60° in the presence of zinc chloride results…”
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Synthesis of 4-(2-acetoxyethoxymethyl)-6-methyl-1,2,4-triazin-3(4H)-one 1-oxide as thymidine analogue by Banijamali, Ali R., Foye, William O.

“…Alkylation of the sodium salt and the trimethyl silylated derivatives of 6‐methyl‐1,2,4‐triazin‐3(4H)‐one 1‐oxide with chloromethoxyethyl acetate, n‐hexyl…”
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Synthesis and antimicrobial activities of N4-(2-acetoxyethoxymethyl)thiosemicarbazones and N3-(2-acetoxyethoxymethyl)thioureas by Foye, W O, Banijamali, A R, Patarapanich, C

“…A series of thiosemicarbazones and thioureas having an open-chain analogue of the ribosyl group, the 2-acetoxyethoxymethyl moiety, has been synthesized…”
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Relationship between azo dye structure and rat hepatic azoreductase activity by Shargel, L, Banijamali, A R, Kuttab, S H

“…The rate of reduction was determined for a variety of azo dyes using the rat hepatic azoreductase enzyme system. In decreasing order, the rates of reduction…”
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