Search Results - "Bange, Hester"

Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective by Kanhai, Anish A., Bange, Hester, Verburg, Lotte, Dijkstra, Kyra L., Price, Leo S., Peters, Dorien J. M., Leonhard, Wouter N.

“…Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic disorders, characterized by the progressive formation of fluid-filled…”
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Computational drug discovery approaches identify mebendazole as a candidate treatment for autosomal dominant polycystic kidney disease by Brownjohn, Philip W, Zoufir, Azedine, O'Donovan, Daniel J, Sudhahar, Saatviga, Syme, Alexander, Huckvale, Rosemary, Porter, John R, Bange, Hester, Brennan, Jane, Thompson, Neil T

“…Autosomal dominant polycystic kidney disease (ADPKD) is a rare genetic disorder characterised by numerous renal cysts, the progressive expansion of which can…”
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Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles by Malas, Tareq B., Leonhard, Wouter N., Bange, Hester, Granchi, Zoraide, Hettne, Kristina M., Van Westen, Gerard J.P., Price, Leo S., 't Hoen, Peter A.C., Peters, Dorien J.M.

“…Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common causes of end-stage renal failure, caused by mutations in PKD1 or PKD2 genes…”
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Identification of Paracrine Factors in the Early Cyst Microenvironment in Polycystic Kidney Disease: FR-PO557 by Yasinoglu, Sevtap A., Kuipers, Thomas B., Bange, Hester, Eikmans, Michael, Mei, Hailiang, Baelde, Hans J., Peters, Dorien J.

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MO019: Preclinical Efficacy of Direct AMPK Activation with a Novel Small Molecule–PXL770–For the Treatment of Autosomal Dominant Polycystic Kidney Disease by Gluais Dagorn, Pascale, Buchholz, Bjoern, Bange, Hester, Blockken, Laura, Moller, David E, Hallakou-Bozec, Sophie

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A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease by Dagorn, Pascale Gluais, Buchholz, Bjoern, Kraus, Andre, Batchuluun, Battsetseg, Bange, Hester, Blockken, Laura, Steinberg, Gregory R, Moller, David E, Hallakou-Bozec, Sophie

“…Autosomal dominant polycystic kidney disease (ADPKD) mainly results from mutations in the PKD1 gene, which encodes polycystin 1. It is the most common…”
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In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease by Booij, Tijmen H, Leonhard, Wouter N, Bange, Hester, Yan, Kuan, Fokkelman, Michiel, Plugge, Anna J, Veraar, Kimberley A M, Dauwerse, Johannes G, van Westen, Gerard J P, van de Water, Bob, Price, Leo S, Peters, Dorien J M

“…Abstract Polycystic kidney disease (PKD) is a prevalent genetic disorder, characterized by the formation of kidney cysts that progressively lead to kidney…”
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