Search Results - "Bang, Injin"

Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains by Kim, Jinuk, Han, Wonhee, Park, Taeyong, Kim, Eun Jin, Bang, Injin, Lee, Hyun Sik, Jeong, Yejin, Roh, Kyeonghwan, Kim, Jeesoo, Kim, Jong-Seo, Kang, Chanhee, Seok, Chaok, Han, Jin-Kwan, Choi, Hee-Jung

“…Low-density lipoprotein receptor-related protein 6 (LRP6) is a coreceptor of the β-catenin-dependent Wnt signaling pathway. The LRP6 ectodomain binds Wnt…”
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Structural basis of neuropeptide Y signaling through Y1 receptor by Park, Chaehee, Kim, Jinuk, Ko, Seung-Bum, Choi, Yeol Kyo, Jeong, Hyeongseop, Woo, Hyeonuk, Kang, Hyunook, Bang, Injin, Kim, Sang Ah, Yoon, Tae-Young, Seok, Chaok, Im, Wonpil, Choi, Hee-Jung

“…Neuropeptide Y (NPY) is highly abundant in the brain and involved in various physiological processes related to food intake and anxiety, as well as human…”
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Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family by Choi, Chulwon, Bae, Jungnam, Kim, Seonghan, Lee, Seho, Kang, Hyunook, Kim, Jinuk, Bang, Injin, Kim, Kiheon, Huh, Won-Ki, Seok, Chaok, Park, Hahnbeom, Im, Wonpil, Choi, Hee-Jung

“…Structural and mechanistic studies on human odorant receptors (ORs), key in olfactory signaling, are challenging because of their low surface expression in…”
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Structural features of β2 adrenergic receptor: crystal structures and beyond by Bang, Injin, Choi, Hee-Jung

“…The beta2-adrenergic receptor (β2AR) family, which is the largest family of cell surface receptors in humans. Extra attention has been focused on the human…”
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Author Correction: Structural basis of neuropeptide Y signaling through Y1 receptor by Park, Chaehee, Kim, Jinuk, Ko, Seung-Bum, Choi, Yeol Kyo, Jeong, Hyeongseop, Woo, Hyeonuk, Kang, Hyunook, Bang, Injin, Kim, Sang Ah, Yoon, Tae-Young, Seok, Chaok, Im, Wonpil, Choi, Hee-Jung

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Author Correction: Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains by Kim, Jinuk, Han, Wonhee, Park, Taeyong, Kim, Eun Jin, Bang, Injin, Lee, Hyun Sik, Jeong, Yejin, Roh, Kyeonghwan, Kim, Jeesoo, Kim, Jong-Seo, Kang, Chanhee, Seok, Chaok, Han, Jin-Kwan, Choi, Hee-Jung

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Biophysical and functional characterization of Norrin signaling through Frizzled4 by Bang, Injin, Kim, Hee Ryung, Beaven, Andrew H., Kim, Jinuk, Ko, Seung-Bum, Lee, Gyu Rie, Lee, Hasup, Im, Wonpil, Seok, Chaok, Chung, Ka Young, Choi, Hee-Jung

“…Wnt signaling is initiated by Wnt ligand binding to the extracellular ligand binding domain, called the cysteine-rich domain (CRD), of a Frizzled (Fzd)…”
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PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis by Kim, Chang Rok, Noda, Taichi, Kim, Hyunkyung, Kim, Gibeom, Park, Seongwan, Na, Yongwoo, Oura, Seiya, Shimada, Keisuke, Bang, Injin, Ahn, Jun-Yeong, Kim, Yong Ryoul, Oh, Se Kyu, Choi, Hee-Jung, Kim, Jong-Seo, Jung, Inkyung, Lee, Ho, Okada, Yuki, Ikawa, Masahito, Baek, Sung Hee

“…Spermatogenesis is a complex process of sperm generation, including mitosis, meiosis, and spermiogenesis. During spermiogenesis, histones in post-meiotic…”
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Functional role of the Frizzled linker domain in the Wnt signaling pathway by Ko, Seung-Bum, Mihara, Emiko, Park, Yedarm, Roh, Kyeonghwan, Kang, Chanhee, Takagi, Junichi, Bang, Injin, Choi, Hee-Jung

“…The Wnt signaling pathway plays a critical role in the developmental and physiological processes of metazoans. We previously reported that the Frizzled4 (FZD4)…”
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Structure of the Intermediate Filament-Binding Region of Desmoplakin by Kang, Hyunook, Weiss, Thomas M, Bang, Injin, Weis, William I, Choi, Hee-Jung

“…Desmoplakin (DP) is a cytoskeletal linker protein that connects the desmosomal cadherin/plakoglobin/plakophilin complex to intermediate filaments (IFs). The…”
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Structural Features of β2 Adrenergic Receptor: Crystal Structures and Beyond by Bang, Injin, Choi, Hee-Jung

“…The beta2-adrenergic receptor (${\beta}2AR$) belongs to the G protein coupled receptor (GPCR) family, which is the largest family of cell surface receptors in…”
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Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain by Bang, Injin, Hattori, Takamitsu, Leloup, Nadia, Corrado, Alexis, Nyamaa, Atekana, Koide, Akiko, Geles, Ken, Buck, Elizabeth, Koide, Shohei

“…Oncogenic mutations in the extracellular domain (ECD) of cell-surface receptors could serve as tumor-specific antigens that are accessible to antibody…”
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Molecular basis for antibody recognition of multiple drug-peptide/MHC complexes by Maso, Lorenzo, Rajak, Epsa, Bang, Injin, Koide, Akiko, Hattori, Takamitsu, Neel, Benjamin G, Koide, Shohei

“…The HapImmune platform exploits covalent inhibitors as haptens for creating major histocompatibility complex (MHC)-presented tumor-specific neoantigens by…”
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Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy by Hattori, Takamitsu, Maso, Lorenzo, Araki, Kiyomi Y, Koide, Akiko, Hayman, James, Akkapeddi, Padma, Bang, Injin, Neel, Benjamin G, Koide, Shohei

“…Intracellular oncoproteins can be inhibited with targeted therapy, but responses are not durable. Immune therapies can be curative, but most oncogene-driven…”
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Molecular basis for PHF7-mediated ubiquitination of histone H3 by Lee, Hyun Sik, Bang, Injin, You, Junghyun, Jeong, Tae-Kyeong, Kim, Chang Rok, Hwang, Minsang, Kim, Jong-Seo, Baek, Sung Hee, Song, Ji-Joon, Choi, Hee-Jung

“…The RING-type E3 ligase has been known for over two decades, yet its diverse modes of action are still the subject of active research. Plant homeodomain (PHD)…”
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Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors by Akkapeddi, Padma, Hattori, Takamitsu, Khan, Imran, Glasser, Eliezra, Koide, Akiko, Ketavarapu, Gayatri, Whaby, Michael, Zuberi, Mariyam, Teng, Kai Wen, Lefler, Julia, Maso, Lorenzo, Bang, Injin, Ostrowski, Michael C, O'Bryan, John P, Koide, Shohei

“…The G12D mutation is among the most common KRAS mutations associated with cancer, in particular, pancreatic cancer. Here, we have developed monobodies, small…”
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Abstract LB044: Selective therapeutic antibodies against oncogenic mutations of the HER2 extracellular region by Bang, Injin, Hattori, Takamitsu, Leloup, Nadia, Corrado, Alexis, Nyamaa, Atekana, Koide, Akiko, Geles, Ken, Buck, Elizabeth, Koide, Shohei

“…Abstract Oncogenic mutations of HER2 have been identified in HER2-low tumors. Such mutations in the extracellular region could serve as tumor-specific antigens…”
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Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and F-actin by Kang, Hyunook, Bang, Injin, Jin, Kyeong Sik, Lee, Boyun, Lee, Junho, Shao, Xiangqiang, Heier, Jonathon A., Kwiatkowski, Adam V., Nelson, W. James, Hardin, Jeff, Weis, William I., Choi, Hee-Jung

“…Intercellular epithelial junctions formed by classical cadherins, β-catenin, and the actin-binding protein α-catenin link the actin cytoskeletons of adjacent…”
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A Conserved Phosphorylation Switch Controls the Interaction between Cadherin and β-Catenin In Vitro and In Vivo by Choi, Hee-Jung, Loveless, Timothy, Lynch, Allison M., Bang, Injin, Hardin, Jeff, Weis, William I.

“…In metazoan adherens junctions, β-catenin links the cytoplasmic tail of classical cadherins to the F-actin-binding protein α-catenin. Phosphorylation of a…”
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Abstract B020: Creating actionable neoantigens by design with KRAS(G12C) covalent inhibitors by Maso, Lorenzo, Hattori, Takamitsu, Araki, Kiyomi, Koide, Akiko, Rajak, Epsa, Hayman, James, Akkapeddi, Padma, Bang, Injin, Neel, Benjamin G., Koide, Shohei

“…Abstract Covalent inhibitors against KRAS(G12C) represent major breakthroughs in the effort to directly and selectively target oncogenic RAS mutants. However,…”
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