Search Results - "Banderali, Umberto"

A Novel Antigen Design Strategy to Isolate Single‐Domain Antibodies that Target Human Nav1.7 and Reduce Pain in Animal Models by Martina, Marzia, Banderali, Umberto, Yogi, Alvaro, Arbabi Ghahroudi, Mehdi, Liu, Hong, Sulea, Traian, Durocher, Yves, Hussack, Greg, van Faassen, Henk, Chakravarty, Balu, Liu, Qing Yan, Iqbal, Umar, Ling, Binbing, Lessard, Etienne, Sheff, Joey, Robotham, Anna, Callaghan, Debbie, Moreno, Maria, Comas, Tanya, Ly, Dao, Stanimirovic, Danica

“…Genetic studies have identified the voltage‐gated sodium channel 1.7 (Nav1.7) as pain target. Due to the ineffectiveness of small molecules and monoclonal…”
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Electrophysiological- and Neuropharmacological-Based Benchmarking of Human Induced Pluripotent Stem Cell-Derived and Primary Rodent Neurons by Jezierski, Anna, Baumann, Ewa, Aylsworth, Amy, Costain, Willard J, Corluka, Slavisa, Banderali, Umberto, Sodja, Caroline, Ribecco-Lutkiewicz, Maria, Alasmar, Salma, Martina, Marzia, Tauskela, Joseph S

“…Human induced pluripotent stem cell (iPSC)-derived neurons are of interest for studying neurological disease mechanisms, developing potential therapies and…”
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Measurement of the membrane potential in small cells using patch clamp methods by Wilson, James R., Clark, Robert B., Banderali, Umberto, Giles, Wayne R.

“…The resting membrane potential, Em, of mammalian cells is a fundamental physiological parameter. Even small changes in Em can modulate excitability,…”
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Impaired stretch modulation in potentially lethal cardiac sodium channel mutants by Banderali, Umberto, Juranka, Peter F., Clark, Robert B., Giles, Wayne R., Morris, Catherine E.

“…R1623Q and R1626P, slowly inactivating mutants of sodium channel, Nav1.5, associate with sporadic Long-QT3 (LQT3), a syndrome involving ventricular…”
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Outer Pore Topology of the ECaC-TRPV5 Channel by Cysteine Scan Mutagenesis by Dodier, Yolaine, Banderali, Umberto, Klein, Hélène, Topalak, Özlem, Dafi, Omar, Simoes, Manuel, Bernatchez, Gérald, Sauvé, Rémy, Parent, Lucie

“…The substituted cysteine accessibility method (SCAM) was used to map the external vestibule and the pore region of the ECaC-TRPV5 calcium-selective channel…”
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Hydrophobic Interactions as Key Determinants to the KCa3.1 Channel Closed Configuration by Garneau, Line, Klein, Háléne, Banderali, Umberto, Longprá-Lauzon, Ariane, Parent, Lucie, Sauvá, Rámy

“…In this study we present evidence that residue Val282 in the S6 transmembrane segment of the calcium-activated KCa3.1 channel constitutes a key determinant of…”
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The elusive Nav1.7: From pain to cancer by Banderali, Umberto, Moreno, Maria, Martina, Marzia

“…Voltage-gated sodium channels (Nav) are protein complexes that play fundamental roles in the transmission of signals in the nervous system, at the…”
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The elusive Na v 1.7: From pain to cancer by Banderali, Umberto, Moreno, Maria, Martina, Marzia

“…Voltage-gated sodium channels (Na ) are protein complexes that play fundamental roles in the transmission of signals in the nervous system, at the…”
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Activation of K+ and Cl- channels in MDCK cells during volume regulation in hypotonic media by BANDERALI, U, ROY, G

“…Single-channel patch-clamp experiments were performed on MDCK cells in order to characterize the ionic channels participating in regulatory volume decrease…”
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The T-type Calcium Channel Cav3.1 in Y79 Retinoblastoma Cells is Regulated by the Epidermal Growth Factor Receptor via the MAPK Signaling Pathway by Banderali, Umberto, Jain, Mohit, Thakur, Satbir, Jayanthan, Aarthi, Belke, Darrell D., Giles, Wayne R., Narendran, Aru

“…Retinoblastoma is the most frequent intraocular cancer in children. It is also one of the most common causes for enucleation and carries a significant…”
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Electrophysiological Alterations of Pyramidal Cells and Interneurons of the CA1 Region of the Hippocampus in a Novel Mouse Model of Dravet Syndrome by Dyment, David A, Schock, Sarah C, Deloughery, Kristen, Tran, Minh Hieu, Ure, Kerstin, Nutter, Lauryl M J, Creighton, Amie, Yuan, Julie, Banderali, Umberto, Comas, Tanya, Baumann, Ewa, Jezierski, Anna, Boycott, Kym M, Mackenzie, Alex E, Martina, Marzia

“…Abstract Dravet syndrome is a developmental epileptic encephalopathy caused by pathogenic variation in SCN1A. To characterize the pathogenic substitution…”
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Membrane trauma and Na+ leak from Nav1.6 channels by Wang, Jun A, Lin, Wei, Morris, Terence, Banderali, Umberto, Juranka, Peter F, Morris, Catherine E

“…During brain trauma, white matter experiences shear and stretch forces that, without severing axons, nevertheless trigger their secondary degeneration. In…”
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Ion channel expression and function in normal and osteoarthritic human synovial fluid progenitor cells by Bertram, Karri L., Banderali, Umberto, Tailor, Pankaj, Krawetz, Roman J.

“…Osteoarthritis (OA) is a chronic disease affecting the cartilage of over 15% of Canadians. Synovial fluid mesenchymal progenitor cells (sfMPCs) are present in…”
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Hydrophobic Interactions as Key Determinants to the KCa3.1 Channel Closed Configuration: AN ANALYSIS OF KCa3.1 MUTANTS CONSTITUTIVELY ACTIVE IN ZERO Ca by Garneau, Line, Klein, Hélène, Banderali, Umberto, Longpré-Lauzon, Ariane, Parent, Lucie, Sauvé, Rémy

“…In this study we present evidence that residue Val²⁸² in the S6 transmembrane segment of the calcium-activated KCa3.1 channel constitutes a key determinant of…”
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Curcumin Blocks Kv11.1 (erg) Potassium Current and Slows Proliferation in the Infant Acute Monocytic Leukemia Cell line THP-1 by Banderali, Umberto, Belke, Darrell, Singh, Anjali, Jayanthan, Aarthi, Giles, Wayne R., Narendran, Aru

“…Acute Myeloid Leukemia (AML) accounts for approximately one fifth of all childhood leukemia yet is responsible for a significant proportion of morbidity and…”
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Hydrophobic interactions as key determinants to the KCa3.1 channel closed configuration. An analysis of KCa3.1 mutants constitutively active in zero Ca2 by Garneau, Line, Klein, Háléne, Banderali, Umberto, Longprá-Lauzon, Ariane, Parent, Lucie, Sauvá, Rámy

“…In this study we present evidence that residue Val282 in the S6 transmembrane segment of the calcium-activated KCa3.1 channel constitutes a key determinant of…”
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Structural determinants of the closed KCa3.1 channel pore in relation to channel gating: results from a substituted cysteine accessibility analysis by Klein, Hélène, Garneau, Line, Banderali, Umberto, Simoes, Manuel, Parent, Lucie, Sauvé, Rémy

“…In this work we address the question of the KCa3.1 channel pore structure in the closed configuration in relation to the contribution of the C-terminal end of…”
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Ion channels in pediatric CNS Atypical Teratoid/Rhabdoid Tumor (AT/RT) cells: potential targets for novel therapeutic agents by Banderali, Umberto, Jayanthan, Aarthi, Hoeksema, Kimberley A., Narendran, Aru, Giles, Wayne R.

“…The central nervous system Atypical Teratoid/Rhabdoid Tumor (CNS AT/RT) is a highly malignant neoplasm that commonly affects infants and young children, and…”
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Repolarization of the mammalian heart action potential is modulated by changes in osmotic strength by Banderali, Umberto, Fink, Martin, Giles, Wayne R.

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Channels for ions and amino acids in kidney cultured cells (MDCK) during volume regulation by Roy, G, Banderali, U

“…A cell line from canine kidney (MDCK) was studied in hypotonic conditions to determine the transport mechanisms involved during regulatory volume decrease…”
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