Search Results - "Bandele, Omari"

Bioflavonoids as Poisons of Human Topoisomerase IIα and IIβ by Bandele, Omari J, Osheroff, Neil

“…Bioflavonoids are human dietary components that have been linked to the prevention of cancer in adults and the generation of specific types of leukemia in…”
Get full text

Safety assessment for Tris(2,4-di-tert-butylphenyl) phosphite (Irgafos 168) used as an antioxidant and stabilizer in food contact applications by Markley, Laura C., González Bonet, Andrés M., Ogungbesan, Adejoke, Bandele, Omari J., Bailey, Allan B., Patton, Geoffrey W.

“…During and after fabrication of polymeric food contact articles (FCA), polymers undergo oxidation by thermal decomposition processes initiated by oxygen, heat,…”
Get full text

(–)-Epigallocatechin Gallate, A Major Constituent of Green Tea, Poisons Human Type II Topoisomerases by Bandele, Omari J, Osheroff, Neil

“…(–)-Epigallocatechin gallate (EGCG) is the most abundant and biologically active polyphenol in green tea, and many of the therapeutic benefits of the beverage…”
Get full text

Dietary Polyphenols as Topoisomerase II Poisons: B Ring and C Ring Substituents Determine the Mechanism of Enzyme-Mediated DNA Cleavage Enhancement by Bandele, Omari J, Clawson, Sara J, Osheroff, Neil

“…Dietary polyphenols are a diverse and complex group of compounds that are linked to human health. Many of their effects have been attributed to the ability to…”
Get full text

The Efficacy of Topoisomerase II-Targeted Anticancer Agents Reflects the Persistence of Drug-Induced Cleavage Complexes in Cells by Bandele, Omari J, Osheroff, Neil

“…Genistein, a widely consumed bioflavonoid with chemopreventative properties in adults, and etoposide, a commonly prescribed anticancer drug, are…”
Get full text

In vitro toxicity screening of chemical mixtures using HepG2/C3A cells by Bandele, Omari J., Santillo, Michael F., Ferguson, Martine, Wiesenfeld, Paddy L.

“…► HepG2/C3A cells were used to assess the cellular effects of three oil dispersants. ► The Corexit dispersants were significantly more cytotoxic than ZI-400. ►…”
Get full text

A review of dietary exposure and toxicological information on epoxidised soybean oil (ESBO) in food-contact applications by Bandele, Omari J., Cureton, LaShonda T., Bailey, Allan B., Ogungbesan, Adejoke

“…Plasticisers have a long history of use in the industrial manufacture and processing of polymers for the purpose of increasing the flexibility and strength of…”
Get full text

Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts by Noureddine, Maher A, Menendez, Daniel, Campbell, Michelle R, Bandele, Omari J, Horvath, Monica M, Wang, Xuting, Pittman, Gary S, Chorley, Brian N, Resnick, Michael A, Bell, Douglas A

“…The p53 tumor suppressor regulates its target genes through sequence-specific binding to DNA response elements (REs). Although numerous p53 REs are…”
Get full text

Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements by Bandele, Omari J, Wang, Xuting, Campbell, Michelle R, Pittman, Gary S, Bell, Douglas A

“…p53 coordinates the expression of an intricate network of genes in response to stress signals. Sequence-specific DNA binding is essential for p53-mediated…”
Get full text

Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk by Wang, Xuting, Pittman, Gary S., Bandele, Omari J., Bischof, Jason J., Liu, Gang, Brothers, John F., Spira, Avrum, Bell, Douglas A.

“…Chronic cigarette smoking exposes airway epithelial cells to thousands of carcinogens, oxidants and DNA-damaging agents, creating a field of molecular injury…”
Get full text

Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements by Millau, Jean-François, Bandele, Omari J, Perron, Josiann, Bastien, Nathalie, Bouchard, Eric F, Gaudreau, Luc, Bell, Douglas A, Drouin, Régen

“…The p53 protein is crucial for adapting programs of gene expression in response to stress. Recently, we revealed that this occurs partly through the formation…”
Get full text

Cleavage of plasmid DNA by eukaryotic topoisomerase II by Bandele, Omari J, Osheroff, Neil

“…Topoisomerase II is an essential enzyme that is required for a number of critical nuclear processes. All of the catalytic functions of topoisomerase II require…”
Get more information

Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure by Bandele, Omari, Camacho, Luísa, Ferguson, Martine, Reimschuessel, Renate, Stine, Cynthia, Black, Thomas, Olejnik, Nicholas, Keltner, Zachary, Scott, Michael, Costa, Gonçalo Gamboa da, Sprando, Robert

“…► Urinary biomarkers have been identified that are proposed to detect renal damage prior to the onset of kidney dysfunction. ► Multiplexed ELISA and gene…”
Get full text

Comparative analysis of the toxicological databases for 6:2 fluorotelomer alcohol (6:2 FTOH) and perfluorohexanoic acid (PFHxA) by Rice, Penelope A., Aungst, Jason, Cooper, Jessica, Bandele, Omari, Kabadi, Shruti V.

“…6:2 Fluorotelomer alcohol (6:2 FTOH) is a short-chain polyfluoroalkyl substance (PFAS) in polymeric PFAS used in fast food packaging and stain- and…”
Get full text

Letter to the editor responding to Anderson et al.’s 2020 letter regarding Rice et al. (2020) by Rice, Penelope A., Aungst, Jason, Cooper, Jessica, Bandele, Omari, Kabadi, Shruti V.

Get full text

Corrigendum to “Comparative analysis of the toxicological databases for 6:2 fluorotelomer alcohol (6:2 FTOH) and perfluorohexanoic acid (PFHxA)” [Food Chem. Toxicol. 138 (2020) 1–16] by Rice, Penelope A., Aungst, Jason, Cooper, Jessica, Bandele, Omari, Kabadi, Shruti V.

Get full text

Reproductive toxicity in rats with crystal nephropathy following high doses of oral melamine or cyanuric acid by Stine, Cynthia B., Reimschuessel, Renate, Keltner, Zachary, Nochetto, Cristina B., Black, Thomas, Olejnik, Nicholas, Scott, Michael, Bandele, Omari, Nemser, Sarah M., Tkachenko, Andriy, Evans, Eric R., Crosby, Tina C., Ceric, Olgica, Ferguson, Martine, Yakes, Betsy J., Sprando, Robert

“…•Pregnant and non-pregnant rats were gavaged with either melamine or cyanuric acid.•Melamine treated dams had more early and late fetal deaths.•Melamine and…”
Get full text

Trust Your Gut: Establishing Confidence in Gastrointestinal Models--An Overview of the State of the Science and Contexts of Use by Debad, Susan, Allen, David, Bandele, Omari, Bishop, Colin, Blaylock, Michaela, Brown, Paul, Bunger, Maureen K, Co, Julia Y, Crosby, Lynn, Daniel, Amber B, Ferguson, Steve S, Ford, Kevin, da Costa, Goncalo Gamboa, Gilchrist, Kristin H, Grogg, Matthew W, Gwinn, Maureen, Hartung, Thomas, Hogan, Simon P, Jeong, Ye Eun, Kass, George E.N, Kenyon, Elaina, Kleinstreuer, Nicole C, Kujala, Ville, Lundquist, Patrik, Matheson, Joanna, McCullough, Shaun D, Melton-Celsa, Angela, Musser, Steven, Oh, Ilung, Oyetade, Oluwakemi B, Patil, Sarita U, Petersen, Elijah J, Sadrieh, Nakissa, Saves, Christie M, Scruggs, Benjamin S, Tan, Yu-Mei, Thelin, Bill, Nelson, M. Tyler, Tarazona, Jose V, Wambaugh, John F, Yang, Jun-Young, Yu, Changwoo, Fitzpatrick, Suzanne

“…The webinar series and workshop titled "Trust Your Gut: Establishing Confidence in Gastrointestinal Models--An Overview of the State of the Science and…”
Get full text

Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: Gavage vs. feeding by Sprando, Robert L., Reimschuessel, Renate, Stine, Cynthia B., Black, Thomas, Olejnik, Nicholas, Scott, Michael, Keltner, Zachary, Bandele, Omari, Ferguson, Martine, Nemser, Sarah M., Tkachenko, Andriy, Evans, Eric, Crosby, Tina, Woodling, Kellie, Loukotková, Lucie, da Costa, Gonçalo Gamboa

“…► The timing and mode of administration of melamine and cyanuric acid exposure are related to toxicity. ► Renal effects occurred rapidly with staggered…”
Get full text

Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements super() by Millau, Jean-Francois, Bandele, Omari J, Perron, Josiann, Bastien, Nathalie, Bouchard, Eric F, Gaudreau, Luc, Bell, Douglas A, Drouin, Regen

“…The p53 protein is crucial for adapting programs of gene expression in response to stress. Recently, we revealed that this occurs partly through the formation…”
Get full text