The burden and natural history of cardiac pathology at TB diagnosis in a high-HIV prevalence district in Zambia: protocol for the TB-Heart study

The burden and natural history of cardiac pathology at TB diagnosis in a high-HIV prevalence district in Zambia: protocol for the TB-Heart study

Tuberculosis (TB) continues to be a major cause of death across sub-Saharan Africa (SSA). In parallel, non-communicable disease and especially cardiovascular disease (CVD) burden has increased substantially in the region. Cardiac manifestations of TB are well-recognised but the extent to which they...

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Bibliographic Details
Published in:BMC cardiovascular disorders Vol. 24; no. 1; pp. 205 - 9
Main Authors: Scopazzini, Marcello S, Chansa, Pamela, Majonga, Edith D, Bual, Nina, Schaap, Albertus, Mateyo, Kondwelani J, Musukuma, Remmy, Mweemba, Veronica, Cheeba, Maina, Mwila, Chipili C, Sigande, Lucheka, Banda, Isabel, Ngulube, Joseph, Shanaube, Kwame, Zenner, Dominik, Ayles, Helen, Shah, Anoop S V
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 10-04-2024
BioMed Central
BMC
Subjects:
Biochemical markers
Cardiac biomarkers
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Complications and side effects
Diagnosis
Echocardiography
Ethylenediaminetetraacetic acid
Heart
HIV
HIV infection
Hospitals
Human immunodeficiency virus
Illiteracy
Infections
Informed consent
Intensive care
Mortality
Natural history
Non-communicable diseases
Pathology
Pericarditis
Prevention
Pulmonary tuberculosis
Risk factors
Study Protocol
Tuberculosis
Ultrasonic imaging
Zambia
United States > US
Cardiovascular disease
Echocardiography
Non-communicable diseases
Cardiac biomarkers
Pulmonary tuberculosis
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Summary:Tuberculosis (TB) continues to be a major cause of death across sub-Saharan Africa (SSA). In parallel, non-communicable disease and especially cardiovascular disease (CVD) burden has increased substantially in the region. Cardiac manifestations of TB are well-recognised but the extent to which they co-exist with pulmonary TB (PTB) has not been systematically evaluated. The aim of this study is to improve understanding of the burden of cardiac pathology in PTB in those living with and without HIV in a high-burden setting. This is a cross-sectional and natural history study to evaluate the burden and natural history of cardiac pathology in participants with PTB in Lusaka, Zambia, a high burden setting for TB and HIV. Participants with PTB, with and without HIV will be consecutively recruited alongside age- and sex-matched TB-uninfected comparators on a 2:1 basis. Participants will undergo baseline assessments to collect clinical, socio-demographic, functional, laboratory and TB disease impact data followed by point-of-care and standard echocardiography. Participants with PTB will undergo further repeat clinical and functional examination at two- and six months follow-up. Those with cardiac pathology at baseline will undergo repeat echocardiography at six months. The outcomes of the study are to a) determine the burden of cardiac pathology at TB diagnosis, b) describe its association with patient-defining risk factors and biochemical markers of cardiac injury and stretch and c) describe the natural history of cardiac pathology during the course of TB treatment.
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ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-024-03877-0