Search Results - "Banaszynski, Laura A."

The roles of histone variants in fine-tuning chromatin organization and function by Martire, Sara, Banaszynski, Laura A.

“…Histones serve to both package and organize DNA within the nucleus. In addition to histone post-translational modification and chromatin remodelling complexes,…”
Get full text

Hira-Dependent Histone H3.3 Deposition Facilitates PRC2 Recruitment at Developmental Loci in ES Cells by Banaszynski, Laura A., Wen, Duancheng, Dewell, Scott, Whitcomb, Sarah J., Lin, Mingyan, Diaz, Nichole, Elsässer, Simon J., Chapgier, Ariane, Goldberg, Aaron D., Canaani, Eli, Rafii, Shahin, Zheng, Deyou, Allis, C. David

“…Polycomb repressive complex 2 (PRC2) regulates gene expression during lineage specification through trimethylation of lysine 27 on histone H3 (H3K27me3). In…”
Get full text

Phosphorylation of histone H3.3 at serine 31 promotes p300 activity and enhancer acetylation by Martire, Sara, Gogate, Aishwarya A., Whitmill, Amanda, Tafessu, Amanuel, Nguyen, Jennifer, Teng, Yu-Ching, Tastemel, Melodi, Banaszynski, Laura A.

“…The histone variant H3.3 is enriched at enhancers and active genes, as well as repeat regions such as telomeres and retroelements, in mouse embryonic stem…”
Get full text

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma by Lewis, Peter W., Müller, Manuel M., Koletsky, Matthew S., Cordero, Francisco, Lin, Shu, Banaszynski, Laura A., Garcia, Benjamin A., Muir, Tom W., Becher, Oren J., Allis, C. David

“…Sequencing of pediatrie gliomas has identified missense mutations Lys27Met (K27M) and Gly34Arg/Val (G34R/V) in genes encoding histone H3.3 (H3F3A) and H3.1…”
Get full text

ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress by Teng, Yu-Ching, Sundaresan, Aishwarya, O’Hara, Ryan, Gant, Vincent U., Li, Minhua, Martire, Sara, Warshaw, Jane N., Basu, Amrita, Banaszynski, Laura A.

“…ATRX is a tumor suppressor that has been associated with protection from DNA replication stress, purportedly through resolution of difficult-to-replicate…”
Get full text

H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells by Tafessu, Amanuel, O'Hara, Ryan, Martire, Sara, Dube, Altair L, Saha, Purbita, Gant, Vincent U, Banaszynski, Laura A

“…The histone variant H3.3 is enriched at active regulatory elements such as promoters and enhancers in mammalian genomes. These regions are highly accessible,…”
Get full text

Establishment and function of chromatin modification at enhancers by Tafessu, Amanuel, Banaszynski, Laura A

“…How a single genome can give rise to distinct cell types remains a fundamental question in biology. Mammals are able to specify and maintain hundreds of cell…”
Get full text

Characterization of the FKBP·Rapamycin·FRB Ternary Complex by Banaszynski, Laura A, Liu, Corey W, Wandless, Thomas J

“…Rapamycin is an important immunosuppressant, a possible anticancer therapeutic, and a widely used research tool. Essential to its various functions is its…”
Get full text

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions by Goldberg, Aaron D., Banaszynski, Laura A., Noh, Kyung-Min, Lewis, Peter W., Elsaesser, Simon J., Stadler, Sonja, Dewell, Scott, Law, Martin, Guo, Xingyi, Li, Xuan, Wen, Duancheng, Chapgier, Ariane, DeKelver, Russell C., Miller, Jeffrey C., Lee, Ya-Li, Boydston, Elizabeth A., Holmes, Michael C., Gregory, Philip D., Greally, John M., Rafii, Shahin, Yang, Chingwen, Scambler, Peter J., Garrick, David, Gibbons, Richard J., Higgs, Douglas R., Cristea, Ileana M., Urnov, Fyodor D., Zheng, Deyou, Allis, C. David

“…The incorporation of histone H3 variants has been implicated in the epigenetic memory of cellular state. Using genome editing with zinc-finger nucleases to tag…”
Get full text

A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules by Banaszynski, Laura A., Chen, Ling-chun, Maynard-Smith, Lystranne A., Ooi, A. G. Lisa, Wandless, Thomas J.

“…Rapid and reversible methods for perturbing the function of specific proteins are desirable tools for probing complex biological systems. We have developed a…”
Get full text

Histone variant H3.3 is an essential maternal factor for oocyte reprogramming by Wen, Duancheng, Banaszynski, Laura A., Liu, Ying, Geng, Fuqiang, Noh, Kyung-Min, Xiang, Jenny, Elemento, Olivier, Rosenwaks, Zev, Allis, C. David, Rafii, Shahin

“…Mature oocyte cytoplasm can reprogram somatic cell nuclei to the pluripotent state through a series of sequential events including protein exchange between the…”
Get full text

Differential contribution of p300 and CBP to regulatory element acetylation in mESCs by Martire, Sara, Nguyen, Jennifer, Sundaresan, Aishwarya, Banaszynski, Laura A

“…The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation…”
Get full text

Histone variant H3.3–mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos by Kong, Qingran, Banaszynski, Laura A., Geng, Fuqiang, Zhang, Xiaolei, Zhang, Jiaming, Zhang, Heng, O’Neill, Claire L., Yan, Peidong, Liu, Zhonghua, Shido, Koji, Palermo, Gianpiero D., Allis, C. David, Rafii, Shahin, Rosenwaks, Zev, Wen, Duancheng

“…Derepression of chromatin-mediated transcriptional repression of paternal and maternal genomes is considered the first major step that initiates zygotic gene…”
Get full text

PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence by Xiao, Michael, Wu, Chia-Hua, Meek, Graham, Kelly, Brian, Castillo, Dara Buendia, Young, Lyndsay E A, Martire, Sara, Dhungel, Sajina, McCauley, Elizabeth, Saha, Purbita, Dube, Altair L, Gentry, Matthew S, Banaszynski, Laura A, Sun, Ramon C, Kikani, Chintan K

“…Quiescent stem cells are activated in response to a mechanical or chemical injury to their tissue niche. Activated cells rapidly generate a heterogeneous…”
Get full text

Transcription pausing regulates mouse embryonic stem cell differentiation by Tastemel, Melodi, Gogate, Aishwarya A., Malladi, Venkat S., Nguyen, Kim, Mitchell, Courtney, Banaszynski, Laura A., Bai, Xiaoying

“…The pluripotency of embryonic stem cells (ESCs) relies on appropriate responsiveness to developmental cues. Promoter-proximal pausing of RNA polymerase II (Pol…”
Get full text

Genome editing a mouse locus encoding a variant histone, H3.3B, to report on its expression in live animals by Wen, Duancheng, Noh, Kyung-Min, Goldberg, Aaron D., Allis, C. David, Rosenwaks, Zev, Rafii, Shahin, Banaszynski, Laura A.

“…Summary Chromatin remodeling via incorporation of histone variants plays a key role in the regulation of embryonic development. The histone variant H3.3 has…”
Get full text

A Directed Approach for Engineering Conditional Protein Stability Using Biologically Silent Small Molecules by Maynard-Smith, Lystranne A., Chen, Ling-chun, Banaszynski, Laura A., Ooi, A.G. Lisa, Wandless, Thomas J.

“…The ability to regulate the function of specific proteins using cell-permeable molecules can be a powerful method for interrogating biological systems. To…”
Get full text

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells by Elsässer, Simon J., Noh, Kyung-Min, Diaz, Nichole, Allis, C. David, Banaszynski, Laura A.

“…Transposable elements in mammalian genomes need to be silenced to avoid detrimental genome instability; here, the histone variant H3.3 is shown to have an…”
Get full text

Analysis of histones and chromatin in Xenopus laevis egg and oocyte extracts by Banaszynski, Laura A., Allis, C. David, Shechter, David

“…Histones are the major protein components of chromatin, the physiological form of the genome in all eukaryotic cells. Chromatin is the substrate of…”
Get full text

Histone Variants in Metazoan Development by Banaszynski, Laura A., Allis, C. David, Lewis, Peter W.

“…Embryonic development is regulated by both genetic and epigenetic mechanisms, with nearly all DNA-templated processes influenced by chromatin architecture…”
Get full text