Search Results - "Banaszak, Lauren G."

Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes by Giudice, Valentina, Banaszak, Lauren G, Gutierrez-Rodrigues, Fernanda, Kajigaya, Sachiko, Panjwani, Reema, Ibanez, Maria Del Pilar Fernandez, Rios, Olga, Bleck, Christopher K, Stempinski, Erin S, Raffo, Diego Quinones, Townsley, Danielle M, Young, Neal S

“…Exosomal microRNAs modulate cancer cell metabolism and the immune response. Specific exosomal microRNAs have been reported to be reliable biomarkers of several…”
Get full text

Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing by Banaszak, Lauren G., Giudice, Valentina, Zhao, Xin, Wu, Zhijie, Gao, Shouguo, Hosokawa, Kohei, Keyvanfar, Keyvan, Townsley, Danielle M., Gutierrez-Rodrigues, Fernanda, Fernandez Ibanez, Maria del Pilar, Kajigaya, Sachiko, Young, Neal S.

“…DNA methyltransferase 3A (DNMT3A) mediates de novo DNA methylation. Mutations in DNMT3A are associated with hematological malignancies, most frequently acute…”
Get full text

Neighborhood disadvantage, insurance status, and molecular profiling of patients with acute myeloid leukemia by Bade, Rory, Banaszak, Lauren G., Osman, Fauzia, Cabral, Paloma, Hassan, Ayesha, Stepanovic, Adam, Reinig, Erica, Mattison, Ryan J.

“…Next-generation sequencing (NGS) is important for prognostication and determining eligibility for targeted therapies in acute myeloid leukemia (AML). The use…”
Get full text

Clinical utility and real-world application of molecular genetic sequencing in the management of patients with acute myeloid leukemia and myelodysplastic syndromes by Banaszak, Lauren G., Reinig, Erica, Lasarev, Michael R., Mattison, Ryan J.

“…Recurrently mutated genes in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have proven useful in risk stratification and clinical…”
Get full text

Role of ASXL1 in hematopoiesis and myeloid diseases by Gao, Xin, You, Xiaona, Droin, Nathalie, Banaszak, Lauren G., Churpek, Jane, Padron, Eric, Geissler, Klaus, Solary, Eric, Patnaik, Mrinal M., Zhang, Jing

“…•ASXL1 hotspot mutations around codon G646 are prevalent in myeloid diseases but are rarely identified in clonal hematopoiesis of indeterminate potential,…”
Get full text

Implementation of a prospective screening strategy to identify adults with a telomere biology disorder among those undergoing lung transplant evaluation for interstitial lung disease by Banaszak, Lauren G, Smith-Simmer, Kelcy, Shoger, Kyle, Lovrien, Lauren, Malik, Amy, Sandbo, Nathan, Sultan, Samir, Guzy, Robert, Lowery, Erin M, Churpek, Jane E

“…Patients with interstitial lung disease (ILD) secondary to telomere biology disorders (TBD) experience increased morbidity after lung transplantation…”
Get full text

CRISPR/Cas9-mediated ASXL1 mutations in U937 cells disrupt myeloid differentiation by Wu, Zhi-Jie, Zhao, Xin, Banaszak, Lauren G, Gutierrez-Rodrigues, Fernanda, Keyvanear, Keyvan, Gao, Shou-Guo, Raffo, Diego Quinones, Kajigaya, Sachiko, Young, Neal S

“…Additional sex combs-like 1 (ASXL1) is a well-known tumor suppressor gene and epigenetic modifier. ASXL1 mutations are frequent in myeloid malignances; these…”
Get full text

A Case of Isolated Myeloid Sarcoma Associated With Germline EGFR T790M Variant: The Importance of Recognizing Potential Germline Variants on Somatic Tumor Sequencing Panels by Walker, Margaret, Folstad, Matthew, Smith-Simmer, Kelcy, Reinig, Erica, Nadiminti, Kalyan, Lovrien, Lauren, Churpek, Jane E., Banaszak, Lauren G.

“…Isolated myeloid sarcoma is an uncommon subtype of acute myeloid leukemia associated with variable prognosis. We present the case of a previously healthy…”
Get full text

Implementation of and Systems-Level Barriers to Guideline-Driven Germline Genetic Evaluation in the Care of Patients With Myelodysplastic Syndrome and Acute Myeloid Leukemia by Banaszak, Lauren G, Cabral, Paloma L, Smith-Simmer, Kelcy, Hassan, Ayesha, Brunner, Matthew, Fallon, Michael, Shoger, Kyle, Lovrien, Lauren, Golner, Danielle, Zurbriggen, Luke, Mattison, Ryan, Gahvari, Zhubin, Hall, Aric, Nadiminti, Kalyan, Reinig, Erica, Churpek, Jane E

“…Knowledge of an inherited predisposition to myelodysplastic syndrome (MDS) and AML has important clinical implications for treatment decisions, surveillance,…”
Get more information

A Comprehensive Microscopy and Peripheral Blood Smear Curriculum for Hematology Fellows by Banaszak, Lauren G, Brunner, Matthew James, Guenther, Chad, Williams, Eliot C.

“…Background: Peripheral blood smear (PBS) analysis is an essential skill for the practicing hematologist and allows for the timely diagnosis of a variety of…”
Get full text

Derivation of a Risk Prediction Model for Venous Thromboembolism in Adult Patients with Acute Myeloid Leukemia by McQuinn, Danielle, Banaszak, Lauren G, Cabral, Paloma L, Reinig, Erica, Hyun, Meredith, Mattison, Ryan J

“…Background: Venous thromboembolism (VTE) is a well-established complication of malignancy associated with high morbidity. Many validated scoring systems exist…”
Get full text

Prevalence and Spectrum of Autoimmune Diseases Among Patients with Telomere Biology Disorder by Kelly, Alaina M, Banaszak, Lauren G, Smith-Simmer, Kelcy, Shoger, Kyle, Donohue, Sarah M, Lowery, Erin, Churpek, Jane E

“…Introduction Telomeres are the protective ends of linear chromosomes that prevent DNA degradation with each replication. Premature attrition or dysfunction of…”
Get full text

Neighborhood Disadvantage, Insurance Status, and Molecular Profiling of Patients with Acute Myeloid Leukemia by Bade, Rory, Banaszak, Lauren G., Osman, Fauzia, Cabral, Paloma, Hassan, Ayesha, Stepanovic, Adam, Reinig, Erica, Mattison, Ryan J.

Get full text

Impact of Early Hospitalization, Medical Comorbidities and Allogeneic Stem Cell Transplantation on Survival in Acute Myeloid Leukemia Patients Treated with Venetoclax Based Therapy - a Single Institution Experience from an Academic Center by Williams, Emma E, McQuinn, Danielle, Banaszak, Lauren G., Ninos, Cameron, Mattison, Ryan J., Gahvari, Zhubin, Hall, Aric C., Fallon, Michael J, Nadiminti, Kalyan VG

Get full text

A Quality Improvement Initiative to Improve Implementation of Guideline-Concordant Hereditary Myeloid Malignancy Syndrome Evaluation by Banaszak, Lauren G., Cabral, Paloma, Smith-Simmer, Kelcy, Hassan, Ayesha, Brunner, Matthew J, Fallon, Michael J, Lovrien, Lauren, Golner, Danielle, Zurbriggen, Luke, Mattison, Ryan J., Gahvari, Zhubin, Hall, Aric C., Nadiminti, Kalyan VG, Reinig, Erica, Churpek, Jane

Get full text

DNA Damage Response Constrains Cell Growth and Drives Clonal Hematopoiesis in Telomere Biology Disorders by Sande, Christopher M, Chen, Stone, Mitchell, Dana V, Lin, Ping, Deolikar, Rujul Jagdish, Freeman, Colby, Zhou, Mary, Kumar, Sushant, Zheng, Shannon, Munkhbileg, Bolormaa, Stanley, Natasha L, Guo, Kathy, Hausler, Ryan, Taylor, Deanne M, Corines, James, Morrissette, Jennifer JD, Lieberman, David B, Yang, Guang, Smith-Simmer, Kelcy, Banaszak, Lauren G, Shoger, Kyle, Nicholas, Peter, Walne, Amanda J, Dokal, Inderjeet, Rosenheck, Justin, Churpek, Jane E, Johnson, F Bradley, Olson, Timothy S, Babushok, Daria V

“…Telomere biology disorders (TBD) are inherited diseases caused by genetic defects in telomere maintenance. Patients with TBD have critically shortened…”
Get full text

Crispr/Cas9-Mediated ASXL1knockout in U937 Human Leukemic Cells Perturbs Myeloid Differentiation by Wu, Zhijie, Zhao, Xin, Banaszak, Lauren G., Keyvanfar, Keyvan, Kajigaya, Sachiko, Young, Neal S.

“…Introduction.Mutations in the Additional Sex Combs Like1 (ASXL1) gene are frequent in myeloid malignances (myelodysplastic syndromes [MDS], myeloproliferative…”
Get full text

Multicenter Study of Mantle Cell Lymphoma Outcomes Following First-Line Bendamustine-Rituximab and Second-Line Bruton's Tyrosine Kinase Inhibitor Therapy by Wang, Yucai, Larson, Melissa C., Hwang, Steven R., Kumar, Anita, Joseph, Ashlee, Hill, Brian T., Brooks, Taylor R., Bond, David A., Maddocks, Kami J., Danilov, Alexey, McCarthy, Christine, Ruan, Jia, Nizamuddin, Imran A., Kahl, Brad S., Grover, Natalie S., Khan, Nazneen B., Ouchveridze, Evguenia, Tun, Aung M., Young, Philip, Portell, Craig A., Harris, Zoey I., Munoz, Javier L., Reagan, Patrick M., Pongas, Georgio, Lossos, Izidore S., Ryan, Christine E., Merryman, Reid W., Baidoun, Firas, Alhaj Moustafa, Muhamad, Gerber, Drew, Ayyappan, Sabarish R., Link, Brian K., Velayati, Arash, Greenwell, Irl Brian, Banaszak, Lauren G, Pophali, Priyanka A, Stack, Anthony C., Messmer, Marcus R., Narkhede, Mayur, Mehta, Amitkumar N., Jain, Preetesh, Wang, Michael L., Moyo, Tamara K., Ghosh, Nilanjan, Bhansali, Rahul S., Barta, Stefan K., Kamdar, Manali K., Anna, Jacob, Stanisic, Alexander V., Karmali, Reem, Kugathasan, Laveniya, Villa, Diego, Maurer, Matthew J., Cerhan, James R., Cohen, Jonathon B., Martin, Peter

“…Background: Bendamustine and rituximab (BR) is a standard-of-care first-line (1L) therapy for older or unfit patients with mantle cell lymphoma (MCL). The…”
Get full text

Crispr/Cas9-Induced DNMT3A Mutations in the K562 Human Leukemic Cell Line As a Model of DNMT3A-Mutated Leukemogenesis by Banaszak, Lauren G., Giudice, Valentina, Zhao, Xin, Wu, Zhijie, Hosokawa, Kohei, Keyvanfar, Keyvan, Townsley, Danielle, Kajigaya, Sachiko, Young, Neal S.

“…Background:DNA methyltransferase 3A(DNMT3A) is a member of the DNA methyltransferase family primarily involved in de novo gene methylation. Mutations in DNMT3A…”
Get full text