Search Results - "Bañas, Stefanie"

CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models by Drake, Penelope M, Carlson, Adam, McFarland, Jesse M, Bañas, Stefanie, Barfield, Robyn M, Zmolek, Wesley, Kim, Yun Cheol, Huang, Betty C B, Kudirka, Romas, Rabuka, David

“…Hematologically derived tumors make up ∼10% of all newly diagnosed cancer cases in the United States. Of these, the non-Hodgkin lymphoma (NHL) designation…”
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Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion by Holder, Patrick G., Jones, Lesley C., Drake, Penelope M., Barfield, Robyn M., Bañas, Stefanie, de Hart, Gregory W., Baker, Jeanne, Rabuka, David

“…To further our aim of synthesizing aldehyde-tagged proteins for research and biotechnology applications, we developed methods for recombinant production of…”
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Site-Specific Tandem Knoevenagel Condensation–Michael Addition To Generate Antibody–Drug Conjugates by Kudirka, Romas A, Barfield, Robyn M, McFarland, Jesse M, Drake, Penelope M, Carlson, Adam, Bañas, Stefanie, Zmolek, Wes, Garofalo, Albert W, Rabuka, David

“…Expanded ligation techniques are sorely needed to generate unique linkages for the growing field of functionally enhanced proteins. To address this need, we…”
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A simple LC/MRM–MS-based method to quantify free linker-payload in antibody-drug conjugate preparations by Zmolek, Wesley, Bañas, Stefanie, Barfield, Robyn M., Rabuka, David, Drake, Penelope M.

“…•A simple MRM-based method to quantify free linker-payload in an ADC is described.•The approach has an LLOQ of 10nM and requires no special laboratory…”
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S3356 Microbial-Derived Protein SG-2-0776 Improves Gut Barrier Function and Prevents Fibrosis by Interacting With the Extracellular Matrix During GI Injury by Raja, Bernat Baeza, La Chat, Chip, Desnoyer, Jill, Hannibal, Roberta, Johnson, Amy Jo A., Yamamoto, Lynn, Raack, Edward, Wilcoxon, Michi, Bañas, Stefanie, Chow, Cheryl-Emiliane T., Dabbagh, Karim, Han, Andrew

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Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions by Huang, Betty C B, Kim, Yun Cheol, Bañas, Stefanie, Barfield, Robyn M, Drake, Penelope M, Rupniewski, Igor, Haskins, William E, Rabuka, David

“…The advantages of site-specific over stochastic bioconjugation technologies include homogeneity of product, minimal perturbation of protein structure/function,…”
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Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes by Drake, Penelope M, Albers, Aaron E, Baker, Jeanne, Banas, Stefanie, Barfield, Robyn M, Bhat, Abhijit S, de Hart, Gregory W, Garofalo, Albert W, Holder, Patrick, Jones, Lesley C, Kudirka, Romas, McFarland, Jesse, Zmolek, Wes, Rabuka, David

“…It is becoming increasingly clear that site-specific conjugation offers significant advantages over conventional conjugation chemistries used to make…”
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Tu1516: IDENTIFICATION AND DEVELOPMENT OF A 1ST IN CLASS NATURALLYDERIVED PROTEIN THAT DRIVES MUCOSAL HEALING AND IS ORALLY DELIVERED BY AN ENGINEERED CELLULAR THERAPY TARGETING THE GASTRO-INTESTINAL TRACT by Shilova, Irina, Chat, Chip La, Nigatu, Eskedar, Messner, Elisabeth, Desnoyer, Jill, Willcoxon, Michi, Banas, Stefanie, Ravichandar, Jayamary Divya, Narayan, Nicole, DeSantis, Todd, Dabbagh, Karim, Yamamoto, Mitsuko L.

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A NOVEL MICROBIALLY-DERIVED PROTEIN CAN BE EXPRESSED IN LACTOCOCCUS LACTIS AND DELIVERED ORALLY TO IMPROVE GUT BARRIER FUNCTION AND PREVENT FIBROGENESIS BY INTERACTING WITH THE EXTRACELLULAR MATRIX DURING GI INJURY by La Chat, Chip, Nigatu, Eskedar, Messner, Elisabeth, Baeza Raja, Bernat, Desnoyer, Jill, Johnson, Amy Jo, Willcoxon, Michi, Banas, Stefanie, Han, Andrew, DeSantis, Todd, Dabbagh, Karim, Shilova, Irina, Yamamoto, Lynn

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A NOVEL MICROBIALLY-DERIVED PROTEIN CAN BE EXPRESSED IN LACTOCOCCUS LACTIS AND DELIVERED ORALLY TO IMPROVE GUT BARRIER FUNCTION AND PREVENT FIBROGENESIS BY INTERACTING WITH THE EXTRACELLULAR MATRIX DURING GI INJURY by La Chat, Chip La, Nigatu, Eskedar, Messner, Elisabeth, Raja, Bernat Baeza, Desnoyer, Jill, Johnson, Amy Jo, Willcoxon, Michi, Banas, Stefanie, Han, Andrew, DeSantis, Todd, Dabbagh, Karim, Shilova, Irina, Yamamoto, Lynn

“…Abstract Intestinal barrier dysfunction or the loss of the epithelial integrity allowing the permeation of microorganisms, dietary antigens and other particles…”
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Exploring the effects of linker composition on site-specifically modified antibody–drug conjugates by Albers, Aaron E., Garofalo, Albert W., Drake, Penelope M., Kudirka, Romas, de Hart, Gregory W., Barfield, Robyn M., Baker, Jeanne, Banas, Stefanie, Rabuka, David

“…In the context of antibody–drug conjugates (ADCs), noncleavable linkers provide a means to deliver cytotoxic small molecules to cell targets while reducing…”
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Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions by Huang, Betty C. B., Kim, Yun Cheol, Bañas, Stefanie, Barfield, Robyn M., Drake, Penelope M., Rupniewski, Igor, Haskins, William E., Rabuka, David

“…The advantages of site-specific over stochastic bioconjugation technologies include homogeneity of product, minimal perturbation of protein structure/function,…”
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Generating Site-Specifically Modified Proteins via a Versatile and Stable Nucleophilic Carbon Ligation by Kudirka, Romas, Barfield, Robyn M., McFarland, Jesse, Albers, Aaron E., de Hart, Gregory W., Drake, Penelope M., Holder, Patrick G., Banas, Stefanie, Jones, Lesley C., Garofalo, Albert W., Rabuka, David

“…There is a need for facile chemistries that allow for chemo- and regioselectivity in bioconjugation reactions. To address this need, we are pioneering…”
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