Search Results - "Bame, Monica"

Effect of Sex on Lifespan, Disease Progression, and the Response to Methionine Sulfoximine in the SOD1 G93A Mouse Model for ALS by Bame, Monica, PhD, Pentiak, Patricia A., MD, Needleman, Richard, PhD, Brusilow, William S.A., PhD

“…Abstract Objective To investigate the role of sex and the role of ammonia and amino acid metabolism, specifically the activity of glutamine synthetase, in…”
Get full text

Epithelial TLR9 upregulation by respiratory viruses impairs pulmonary antibacterial immunity by Rich, Helen Eva Adams, Bhutia, Simran, Martínez-Colón, Giovanny, Warheit-Niemi, Helen, Bame, Monica, Moore, Bethany

“…While much is known about signaling downstream of the dsDNA sensor TLR9, regulation of its expression is underexplored and has significant consequences for…”
Get full text

Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2 by Melvin, William J., Audu, Christopher O., Davis, Frank M., Sharma, Sriganesh B., Joshi, Amrita, DenDekker, Aaron, Wolf, Sonya, Barrett, Emily, Mangum, Kevin, Zhou, Xiaofeng, Bame, Monica, Ruan, Alex, Obi, Andrea, Kunkel, Steven L., Moore, Bethany B., Gallagher, Katherine A.

“…COVID-19 induces a robust, extended inflammatory “cytokine storm” that contributes to an increased morbidity and mortality, particularly in patients with type…”
Get full text

RSV enhances Staphylococcus aureus bacterial growth in the lung by Rich, Helen E, Bhutia, Simran, Gonzales de Los Santos, Francina, Entrup, Gabrielle P, Warheit-Niemi, Helen I, Gurczynski, Stephen J, Bame, Monica, Douglas, Michael T, Morris, Susan B, Zemans, Rachel L, Lukacs, Nicholas W, Moore, Bethany B

“…Patients coinfected with respiratory syncytial virus (RSV) and bacteria have longer hospital stays, higher risk of intensive care unit admission, and worse…”
Get full text

Cohort Profile: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder by McInnis, Melvin G, Assari, Shervin, Kamali, Masoud, Ryan, Kelly, Langenecker, Scott A, Saunders, Erika F H, Versha, Kritika, Evans, Simon, O'Shea, K Sue, Mower Provost, Emily, Marshall, David, Forger, Daniel, Deldin, Patricia, Zoellner, Sebastian

Get full text

The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation by Sharma, Sriganesh B., Melvin, William J., Audu, Christopher O., Bame, Monica, Rhoads, Nicole, Wu, Weisheng, Kanthi, Yogendra, Knight, Jason S., Adili, Reheman, Holinstat, Michael A., Wakefield, Thomas W., Henke, Peter K., Moore, Bethany B., Gallagher, Katherine A., Obi, Andrea T.

“…•Monocyte/macrophage MLL1 promotes the expression of coagulopathy-related factors and proinflammatory cytokines after coronavirus infection.•Loss of…”
Get full text

T101. Accelerated Maturation Phenotypes in Patient-Derived Cell Models of Bipolar Disorder by Williams, Aislinn, Bame, Monica, DeLong, Cynthia, Glanowska, Katarzyna, Cazares, Victor, Dhond, Rasika, Smarsh, Austin, Eric, Cousineau, Martinez, Emily, Lim, Kim-Chew, McInnis, Melvin, Murphy, Geoffrey, O'Shea, K. Sue

Get full text

STEM CELL MODELS OF BIPOLAR DISORDER - A DEVELOPMENTAL PERSPECTIVE by McInnis, Melvin, Bame, Monica, Delong, Cindy, Williams, Aislin, Martinez, Emily, Oshea, K Sue

“…A major challenge in understanding human neuropsychiatric disorders is the lack of viable cells and tissues for analysis. Patient-derived induced pluripotent…”
Get full text

Amino Acids as biomarkers in the SOD1G93A mouse model of ALS by Bame, Monica, Grier, Robert E., Needleman, Richard, Brusilow, William S.A.

“…The development of therapies for Amyotrophic Lateral Sclerosis (ALS) has been hindered by the lack of biomarkers for both identifying early disease and for…”
Get full text

716. Abnormal Calcium Signaling Dynamics in iPSC-Derived Bipolar Disorder Neurons by Williams, Aislinn, Smarsh, Austin, Cazares, Victor, Glanowska, Katarzyna, DeLong, Cynthia, Bame, Monica, Martinez, Emily, Lim, Kim-Chew, Parent, Rachel, Stuenkel, Edward, McInnis, Melvin, Murphy, Geoffrey, O׳Shea, K Sue

Get full text

Abnormal Calcium Signaling Dynamics in iPSC-Derived Bipolar Disorder Neurons by Williams, Aislinn, Smarsh, Austin, Cazares, Victor, Glanowska, Katarzyna, DeLong, Cynthia, Bame, Monica, Martinez, Emily, Lim, Kim-Chew, Parent, Rachel, Stuenkel, Edward, McInnis, Melvin, Murphy, Geoffrey, O׳Shea, K Sue

Get full text

Amino acids as biomarkers in the SOD1(G93A) mouse model of ALS by Bame, Monica, Grier, Robert E, Needleman, Richard, Brusilow, William S A

“…The development of therapies for Amyotrophic Lateral Sclerosis (ALS) has been hindered by the lack of biomarkers for both identifying early disease and for…”
Get more information

Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS by Ghoddoussi, Farhad, Galloway, Matthew P, Jambekar, Amruta, Bame, Monica, Needleman, Richard, Brusilow, William S.A

“…Abstract In an effort to alter the levels of neurochemicals involved in excitotoxicity, we treated mice with methionine sulfoximine (MSO), an inhibitor of…”
Get full text

Understanding the gender-based mechanism of MSO treatment in ALS mice: A metabolic characterization of the SOD1-G93A mouse model by Bame, Monica A

“…Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease characterized by motor neuron death and a corresponding loss of neuromuscular…”
Get full text

Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD, by MAP kinase by Sigoillot, Frederic D, Kotsis, Damian H, Masko, Elizabeth M, Bame, Monica, Evans, David R, Evans, Hedeel I Guy

“…The multifunctional protein CAD initiates de novo pyrimidine biosynthesis in mammalian cells. CAD is activated by MAP kinase (Erk1/2) just prior to the S phase…”
Get full text