Search Results - "Bamber, Bruce A"

Reduced Ca2+ transient amplitudes may signify increased or decreased depolarization depending on the neuromodulatory signaling pathway by Debnath, Arunima, Williams, Paul D. E., Bamber, Bruce A.

“…Neuromodulators regulate neuronal excitability and bias neural circuit outputs. Optical recording of neuronal Ca 2+ transients is a powerful approach to study…”
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Serotonin differentially modulates Ca2+ transients and depolarization in a C. elegans nociceptor by Zahratka, Jeffrey A, Williams, Paul D E, Summers, Philip J, Komuniecki, Richard W, Bamber, Bruce A

“…Monoamines and neuropeptides modulate neuronal excitability and synaptic strengths, shaping circuit activity to optimize behavioral output. In C. elegans, a…”
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Cannabinoids Activate Monoaminergic Signaling to Modulate Key C. elegans Behaviors by Oakes, Mitchell D, Law, Wen Jing, Clark, Tobias, Bamber, Bruce A, Komuniecki, Richard

“…, or marijuana, a popular recreational drug, alters sensory perception and exerts a range of potential medicinal benefits. The present study demonstrates that…”
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The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues by Twede, Vernon, Tartaglia, Anthony L, Covey, Douglas F, Bamber, Bruce A

“…Neurosteroids are endogenous neuromodulators that bind and allosterically regulate GABA(A) receptors. Residues were recently identified in the first…”
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Shaping Cellular Form and Function by Autophagy by Bamber, Bruce A., Rowland, Aaron M.

“…In addition to its familiar role in non-selective bulk degradation of cellular material, autophagy can also bring about specific changes in the structure and…”
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Serotonin Disinhibits a Caenorhabditis elegans Sensory Neuron by Suppressing Ca2+-Dependent Negative Feedback by Williams, Paul D E, Zahratka, Jeffrey A, Rodenbeck, Matthew, Wanamaker, Jason, Linzie, Hilary, Bamber, Bruce A

“…Neuromodulators, such as serotonin (5-HT), alter neuronal excitability and synaptic strengths, and define different behavioral states. Neuromodulator-dependent…”
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Multiple Sensory Inputs Are Extensively Integrated to Modulate Nociception in C. elegans by Summers, Philip J, Layne, Robert M, Ortega, Amanda C, Harris, Gareth P, Bamber, Bruce A, Komuniecki, Richard W

“…Sensory inputs are integrated extensively before decision making, with altered multisensory integration being associated with disorders such as autism. We…”
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Serotonin Disinhibits a Caenorhabditis elegans Sensory Neuron by Suppressing Ca 2+ -Dependent Negative Feedback by Williams, Paul D E, Zahratka, Jeffrey A, Rodenbeck, Matthew, Wanamaker, Jason, Linzie, Hilary, Bamber, Bruce A

“…Neuromodulators, such as serotonin (5-HT), alter neuronal excitability and synaptic strengths, and define different behavioral states. Neuromodulator-dependent…”
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Presynaptic Terminals Independently Regulate Synaptic Clustering and Autophagy of GABAA Receptors in Caenorhabditis elegans by Rowland, Aaron M, Richmond, Janet E, Olsen, Jason G, Hall, David H, Bamber, Bruce A

“…Synaptic clustering of GABAA receptors is important for the function of inhibitory synapses, influencing synapse strength and, consequently, the balance of…”
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Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity by BAKER, Carrie, STURT, Brianne L, BAMBER, Bruce A

“…Neurosteroids exert potent physiological effects by allosterically modulating synaptic and extrasynaptic GABA(A) receptors. Some endogenous neurosteroids, such…”
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Automated quantification of synaptic fluorescence in C. elegans by Sturt, Brianne L, Bamber, Bruce A

“…Synapse strength refers to the amplitude of postsynaptic responses to presynaptic neurotransmitter release events, and has a major impact on overall neural…”
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The Caenorhabditis elegans unc-49 Locus Encodes Multiple Subunits of a Heteromultimeric GABA Receptor by Bamber, Bruce A, Beg, Asim A, Twyman, Roy E, Jorgensen, Erik M

“…Ionotropic GABA receptors generally require the products of three subunit genes. By contrast, the GABA receptor needed for locomotion in Caenorhabditis elegans…”
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Regulated lysosomal trafficking as a mechanism for regulating GABAA receptor abundance at synapses in Caenorhabditis elegans by Davis, Kathleen M, Sturt, Brianne L, Friedmann, Andrew J, Richmond, Janet E, Bessereau, Jean-Louis, Grant, Barth D, Bamber, Bruce A

“…GABA(A) receptor plasticity is important for both normal brain function and disease progression. We are studying GABA(A) receptor plasticity in Caenorhabditis…”
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The composition of the GABA receptor at the Caenorhabditis elegans neuromuscular junction by Bamber, Bruce A, Richmond, Janet E, Otto, James F, Jorgensen, Erik M

“…1 The unc‐49 gene of the nematode Caenorhabditis elegans encodes three γ‐aminobutyric acid type A (GABAA) receptor subunits. Two of these, UNC‐49B and UNC‐49C,…”
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Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate by Wardell, Bryan, Marik, Purba S, Piper, David, Rutar, Tina, Jorgensen, Erik M, Bamber, Bruce A

“…The GABA(A) receptor is a target of endogenous and synthetic neurosteroids. Little is known about the residues required for neurosteroid action on GABA(A)…”
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Pharmacological characterization of the homomeric and heteromeric UNC‐49 GABA receptors in C. elegans by Bamber, Bruce A, Twyman, Roy E, Jorgensen, Erik M

“…UNC‐49B and UNC‐49C are γ‐aminobutyric acid (GABA) receptor subunits encoded by the Caenorhabditis elegans unc‐49 gene. UNC‐49B forms a homomeric GABA…”
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“Getting Under the Hood” of Neuronal Signaling in Caenorhabditis elegans by Williams, Paul DE, Zahratka, Jeffrey A, Bamber, Bruce A

“…Caenorhabditis elegans is a powerful model to study the neural and biochemical basis of behavior. It combines a small, completely mapped nervous system,…”
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes by Klionsky, Daniel J., Abeliovich, Hagai, Agostinis, Patrizia, Aliev, Gjumrakch, Ballabio, Andrea, Bamber, Bruce A., Bi, Xiaoning, Biard-Piechaczyk, Martine, Bredesen, Dale E., Cebollero, Eduardo, Cecconi, Francesco, Chu, Charleen T., Chung, Jongkyeong, Clarke, Peter G.H., Clarke, Steven G., Cleveland, John L., Colombo, María Isabel, Coto-Montes, Ana, Deretic, Vojo, Di Sano, Federica, Dinesh-Kumar, Savithramma P., Eissa, N. Tony, DiFiglia, Marian, Dorsey, Frank C., Dröge, Wulf, Dron, Michel, Duszenko, Michael, Esclatine, Audrey, Fésüs, László, Finley, Kim D., Fujisaki, Kozo, Gewirtz, David A., Gohla, Antje, Goldberg, Alfred L., Gonzalez, Ramon, He, You-Wen, Hill, Joseph A., Huang, Wei-Pang, Jäättelä, Marja, Jiang, Xuejun, Jin, Shengkan V., Kang, Chanhee, Kelekar, Ameeta, Kiel, Jan A.K.W., Kimchi, Adi, Kinsella, Timothy J., Kiselyov, Kirill, Kitamoto, Katsuhiko, Komatsu, Masaaki, Kondo, Seiji, Kumar, Rakesh, Laporte, Marianne, Liou, Willisa, Macleod, Kay F., Martinet, Wim, Mautner, Josef, Meléndez, Alicia, Miotto, Giovanni, Mistiaen, Wilhelm P., Münz, Christian, Naqvi, Naweed I., Nishino, Ichizo, Noda, Takeshi, Ogawa, Michinaga, Ozpolat, Bulent, Paglin, Shoshana, Palmer, Glen E., Perlmutter, David H., Piacentini, Mauro, Pinkas-Kramarski, Ronit, Rami, Abdelhaq, Sandri, Marco, Sass, Miklós, Seleverstov, Oleksandr, Settleman, Jeffrey, Shacka, John J., Sibirny, Andrei A., Silva-Zacarin, Elaine C.M., Simonsen, Anne, Smith, Mark A., Srinivas, Vickram, Stenmark, Harald, Sulzer, David, Tabas, Ira, Takeshita, Fumihiko, Tanaka, Keiji, Taylor, J. Paul, Terman, Alexei, Thompson, Craig B., Tolkovsky, Aviva M., Tumanovska, Lesya V., Uchiyama, Yasuo, Ueno, Takashi, Uzcátegui, Néstor L., Vaquero, Eva C., Webster, Paul, Xi, Zhijun, Yue, Zhenyu, Zheng, Xiaoxiang, Deter, Russell L.

“…Research in autophagy continues to accelerate,(1) and as a result many new scientists are entering the field. Accordingly, it is important to establish a…”
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Leukemia Inhibitory Factor Induces Neurotransmitter Switching in Transgenic Mice by Bamber, Bruce A., Masters, Brian A., Hoyle, Gary W., Brinster, Ralph L., Palmiter, Richard D.

“…Leukemia inhibitory factor (LIF) is a cytokine growth factor that induces rat sympathetic neurons to switch their neurotransmitter phenotype from noradrenergic…”
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Serotonin Disinhibits a Caenorhabditis elegans Sensory Neuron by Suppressing Ca^sup 2+^-Dependent Negative Feedback by Williams, Paul DE, Zahratka, Jeffrey A, Rodenbeck, Matthew, Wanamaker, Jason, Linzie, Hilary, Bamber, Bruce A

“…Neuromodulators, such as serotonin (5-HT), alter neuronal excitability and synaptic strengths, and define different behavioral states. Neuromodulator-dependent…”
Get full text