Impact of HIV-1, HIV-2, and HIV-1+2 dual infection on the outcome of tuberculosis

Impact of HIV-1, HIV-2, and HIV-1+2 dual infection on the outcome of tuberculosis

Highlights • In West Africa both HIV-1 and HIV-2 are prevalent and have different impacts on tuberculosis (TB) risk and outcome. • We included 1312 patients in this study, of whom 379 were HIV-infected: 241 had HIV-1, 93 had HIV-2, and 45 were HIV-1+2 dually infected. • The HIV type-associated risk...

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Bibliographic Details
Published in:International journal of infectious diseases Vol. 32; no. C; pp. 128 - 134
Main Authors: Wejse, C, Patsche, C.B, Kühle, A, Bamba, F.J.V, Mendes, M.S, Lemvik, G, Gomes, V.F, Rudolf, F
Format: Journal Article
Language:English
Published: Canada Elsevier Ltd 01-03-2015
Elsevier
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Coinfection - epidemiology
Coinfection - mortality
Female
Follow-Up Studies
Guinea-Bissau - epidemiology
HIV Infections - complications
HIV Infections - epidemiology
HIV-1
HIV-2
Humans
Incidence
Infectious Disease
Longitudinal Studies
Male
Middle Aged
Mortality
Prevalence
Prospective Studies
Pulmonary/Respiratory
Treatment Outcome
Tuberculosis
Tuberculosis - diagnosis
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis - mortality
Young Adult
Guinea-Bissau
HIV-1
Tuberculosis
HIV-2
Mortality
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Summary:Highlights • In West Africa both HIV-1 and HIV-2 are prevalent and have different impacts on tuberculosis (TB) risk and outcome. • We included 1312 patients in this study, of whom 379 were HIV-infected: 241 had HIV-1, 93 had HIV-2, and 45 were HIV-1+2 dually infected. • The HIV type-associated risk of TB was 6-fold higher for HIV-1, 7-fold higher for HIV-1+2 dual infection, and 2-fold higher for HIV-2, compared with the HIV-uninfected. • More females than males were HIV-infected (36% vs. 25%; p < 0.001) and more females had a body mass index (BMI) <15 kg/m2 (11% vs. 6%; p < 0.001). • Of the patients included, 144 (11%) died: 62 (12%) among females and 82 (9%) among males. • HIV infection increased the mortality risk, with HIV-1 infection displaying the highest hazard ratio (HR) at 5, followed by HIV-1+2 infection (HR 4.2) and HIV-2 infection (HR 2.1).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2014.12.015