Search Results - "Balwierczak, J L"

Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500 by Balwierczak, J L, Bruseo, C W, DelGrande, D, Jeng, A Y, Savage, P, Shetty, S S

“…IRL 2500 [N-(3,5-dimethylbenzoyl)-N-methyl-(D)-(4-phenylphenyl)-alany l-L- tryptophan] inhibited the binding of [125I]-endothelin-1 (ET-1) to human ETB (IC50…”
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The relationship of KCl‐ and prostaglandin F2α‐mediated increases in tension of the porcine coronary artery with changes in intracellular Ca2+measured with fura‐2 by Balwierczak, Joseph L.

“…1 Changes in intracellular free Ca2+concentration ([Ca2+]i) were measured simultaneously with changes in muscle tension by use of the fluorescent…”
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Effects of metalloprotease inhibitors on smooth muscle endothelin-converting enzyme activity by BALWIERCZAK, J. L, KUKKOLA, P. J, SAVAGE, P, JENG, A. Y

“…The enzyme responsible for the conversion of exogenous big endothelin-1 to endothelin-1 by porcine coronary arterial smooth muscle has been shown to be a…”
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Effects of adenosine A2 receptor agonists on nucleoside transport by Balwierczak, J L, Krulan, C M, Wang, Z C, Chen, J, Jeng, A Y

“…A series of adenosine A2 receptor agonists were examined for their ability to activate adenosine A2 receptors and inhibit nucleoside transport. A2 receptor…”
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The relationship between the binding site of [3H]-d-cis-diltiazem and that of other non-dihydropyridine calcium entry blockers in cardiac sarcolemma by Balwierczak, J L, Johnson, C L, Schwartz, A

“…[3H]-d-cis-Diltiazem binds to canine cardiac sarcolemma in a specific, saturable, and reversible manner with a KD = 58.0 +/- 9.5 nM and a receptor site density…”
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Effects of bepridil and diltiazem on [3H]nitrendipine binding to canine cardiac sarcolemma. Potentiation of pharmacological effects of nitrendipine by bepridil by Balwierczak, J L, Grupp, I L, Grupp, G, Schwartz, A

“…[3H]Nitrendipine binds to canine cardiac sarcolemma in a specific, saturable and rapid manner. Bepridil, a Ca++ channel inhibitor, stimulates this binding at…”
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Comparative effects of a selective adenosine A2 receptor agonist, CGS 21680, and nitroprusside in vascular smooth muscle by Balwierczak, J L, Sharif, R, Krulan, C M, Field, F P, Weiss, G B, Miller, M J

“…CGS 21680 (2-[p-(2-carboxyethyl)phenylethylamino]-5'-N-ethyolcarboxamidoa denosine) is an adenosine agonist that has been reported recently to bind selectively…”
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A simple assay for the measurement of conversion of big endothelin-1 to endothelin-1 by smooth muscle by Balwierczak, J L, Wong, M, Jeng, A Y

“…The conversion of exogenous big endothelin-1 to endothelin-1 by the smooth muscle of denuded porcine coronary arterial strips was measured by radioimmunoassay…”
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Specific binding of [3H]d-cis-diltiazem to cardiac sarcolemma and its inhibition by calcium by Balwierczak, J L, Schwartz, A

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Correlation of nitrendipine and Bay k 8644 binding to isolated canine heart sarcolemma with their pharmacological effects on the canine heart by Vaghy, P L, Grupp, I L, Grupp, G, Balwierczak, J L, Williams, J S, Schwartz, A

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Decrease in immunoreactivity and vasoactivity of endothelin-1 after exposure to oxygen by Balwierczak, J L, Hopkins, M F, Savage, P, Martin, L L, Jeng, A Y

“…Endothelin-1 (ET-1) caused a dose-dependent contraction of porcine coronary arterial rings. Preincubation of ET-1 in oxygenated Krebs solution at 37 degrees C…”
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Two subtypes of the endothelin receptor (ETA and ETB) mediate vasoconstriction in the perfused rat heart by Balwierczak, J L

“…The effects of endothelin-1 (ET-1) are mediated by two subclasses of the endothelin receptor, ETA and ETB. The Langendorff perfused rat heart was used to…”
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Benzofused Macrocyclic Lactams as Triple Inhibitors of Endothelin-Converting Enzyme, Neutral Endopeptidase 24.11, and Angiotensin-Converting Enzyme by Ksander, Gary M, Savage, Paula, Trapani, Angelo J, Balwierczak, Joseph L, Jeng, Arco Y

“…The purpose of this study was to identify endothelin-converting enzyme (ECE) inhibitors that also possess inhibitory activity for neutral endopeptidase 24.11…”
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Different affinities and selectivities of endothelin-1 and endothelin-3 binding to various rat tissues by Jeng, A Y, Savage, P, Soriano, A, Balwierczak, J L

“…Inhibition of [125I]endothelin-1 ([125I]ET-1) binding to membrane fractions from various rat tissues by ET-1 and endothelin-3 (ET-3) was investigated. Brain…”
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Evidence that BKCa channel activation contributes to K+ channel opener induced relaxation of the porcine coronary artery by Balwierczak, J L, Krulan, C M, Kim, H S, DelGrande, D, Weiss, G B, Hu, S

“…The rank order of potency of a series of benzopyran and cyanoguanidine K+ channel openers (KCOs) for causing relaxation of the PGF2 alpha-precontracted porcine…”
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Purification and characterization of an endothelin degradation enzyme from rat kidney by Deng, A Y, Martin, L L, Balwierczak, J L, Jeng, A Y

“…A soluble protease which effectively inactivated endothelin-1 was purified 2,700-fold from rat kidney using DE52 anion exchange, concanavalin A-Sepharose,…”
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Effects of metalloprotease inhibitors on the conversion of proendothelin-1 to endothelin-1 by Trapani, A J, Balwierczak, J L, Lappe, R W, Stanton, J L, Graybill, S C, Hopkins, M F, Savage, P, Sperbeck, D M, Jeng, A Y

“…The IC50 values of phosphoramidon, CGS 25015, CGS 26129, thiorphan and benazeprilat for inhibition of endothelin converting enzyme partially purified from…”
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Dipeptide sulfonamides as endothelin ETA/ETB receptor antagonists by Ksander, Gary M, Shetty, Suraj S, DelGrande, Dominick, Balwierczak, Joseph L, Bruseo, Charles W, Savage, Paula, deJesus, Reynalda, Yuan, Andrew, Webb, Randy L, Jeng, Arco Y

“…Endothelin-1 (ET-1) is a potent mitogen and modulator of vascular tone. It is synthesized and released from endothelial cells and acts upon two receptor…”
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