Search Results - "Baltus, Christine B."

Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors by Baltus, Christine B., Jorda, Radek, Marot, Christophe, Berka, Karel, Bazgier, Václav, Kryštof, Vladimír, Prié, Gildas, Viaud-Massuard, Marie-Claude

“…From four molecules, inspired by the structural features of fascaplysin, with an interesting potential to inhibit cyclin-dependent kinases (CDKs), we designed…”
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Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells by Longo, Alessandra, Librizzi, Mariangela, Chuckowree, Irina S, Baltus, Christine B, Spencer, John, Luparello, Claudio

“…BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast…”
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Impact of Maleimide Disubstitution on Chemical and Biological Characteristics of HER2 Antibody–Drug Conjugates by Feuillâtre, Ofelia, Gély, Camille, Huvelle, Steve, Baltus, Christine B, Juen, Ludovic, Joubert, Nicolas, Desgranges, Audrey, Viaud-Massuard, Marie-Claude, Martin, Camille

“…Antibody–drug conjugates (ADCs) are the spearhead of targeted therapies. According to the technology used, the conjugation of a cytotoxic drug to an antibody…”
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Olefin cross-metathesis/Suzuki–Miyaura reactions on vinylphenylboronic acid pinacol esters by Baltus, Christine B., Chuckowree, Irina S., Press, Neil J., Day, Iain J., Coles, Simon J., Tizzard, Graham J., Spencer, John

“…A series of alkenyl phenylboronic acid pinacol esters has been synthesized via an olefin cross-metathesis reaction of vinylphenylboronic acid pinacol ester…”
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A synthetic, catalytic and theoretical investigation of an unsymmetrical SCN pincer palladacycle by Roffe, Gavin W., Boonseng, Sarote, Baltus, Christine B., Coles, Simon J., Day, Iain J., Jones, Rhiannon N., Press, Neil J., Ruiz, Mario, Tizzard, Graham J., Cox, Hazel, Spencer, John

“…The SCN ligand 2-{3-[(methylsulfanyl)methyl]phenyl}pyridine, 1, has been synthesized starting from an initial Suzuki–Miyaura (SM) coupling between…”
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Innovative Bioconjugation Technology for Antibody–Drug Conjugates: Proof of Concept in a CD30-Positive Lymphoma Mouse Model by Juen, Ludovic, Baltus, Christine B, Gély, Camille, Feuillâtre, Ofelia, Desgranges, Audrey, Viaud-Massuard, Marie-Claude, Martin, Camille

“…To overcome stability and heterogeneity issues of antibody–drug conjugates (ADCs) produced with existing bioconjugation technologies incorporating a maleimide…”
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Therapeutic Potential of MF-TTZ-MMAE, a Site-Specifically Conjugated Antibody-Drug Conjugate, for the Treatment of HER2-Overexpressing Breast Cancer by Juen, Ludovic, Baltus, Christine B, Gély, Camille, Kervarrec, Thibault, Feuillâtre, Ofelia, Desgranges, Audrey, Viaud-Massuard, Marie-Claude, Martin, Camille

“…With three clinically approved antibody-drug conjugates targeting HER2, this target is clearly identified to be of interest in oncology. Moreover, the advent…”
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Thermal analysis of novel biphenylamide derivatives: Influence of positional and functional group isomerism on solid-state properties by Owusu-Ware, Samuel K., Cherry, Anthony J., Baltus, Christine B., Spencer, John, Antonijevic, Milan D.

“…The physicochemical properties of a small library of 4-methyl-biphenylamide derivatives have been investigated by means of differential scanning calorimetry,…”
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Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state by Baltus, Christine B., Press, Neil J., Antonijevic, Milan D., Tizzard, Graham J., Coles, Simon J., Spencer, John

“…A biphenyl library incorporating amide and sulfonamide groups has been synthesised via microwave-mediated Suzuki–Miyaura couplings. Many derivatives were…”
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Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki–Miyaura cross-couplings by Spencer, John, Baltus, Christine B., Press, Neil J., Harrington, Ross W., Clegg, William

“…Boc-protected (piperazin-1-ylmethyl)biaryls have been synthesised from (Boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters via a microwave-mediated…”
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Microwave-Mediated Synthesis of an Arylboronate Library by Spencer, John, Baltus, Christine B, Patel, Hiren, Press, Neil J, Callear, Samantha K, Male, Louise, Coles, Simon J

“…A series of arylboronates has been synthesized from the reaction of 2-(2-, (3-, or (4-(bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1{1−3}…”
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Suzuki-miyaura mediated biphenyl synthesis: a spotlight on the boronate coupling partner by Baltus, Christine B

“…The biaryl motif is found in many natural and synthetic products that display a wide range of biological activities. This explains why biphenyls are widely…”
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Suzuki-Miyaura mediated biphenyl synthesis : a spotlight on the boronate coupling partner by Baltus, Christine B

“…The biaryl motif is found in many natural and synthetic products that display a wide range of biological activities. This explains why biphenyls are widely…”
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