Search Results - "Baltrusch, Simone"

The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes by Langer, Sara, Waterstradt, Rica, Hillebrand, Georg, Santer, René, Baltrusch, Simone

“…Aims/hypothesis The mammalian enzyme glucokinase (GK), expressed predominantly in liver and pancreas, plays an essential role in carbohydrate metabolism…”
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Imaging and quantification of subbasal nerve plexus in healthy volunteers and diabetic patients with or without retinopathy by Zhivov, Andrey, Winter, Karsten, Hovakimyan, Marine, Peschel, Sabine, Harder, Volker, Schober, Hans-Christof, Kundt, Guenther, Baltrusch, Simone, Guthoff, Rudolf F, Stachs, Oliver

“…The alterations of subbasal nerve plexus (SBP) innervation and corneal sensation were estimated non-invasively and compared with the values in healthy…”
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Identification of the Ubiquitin-like Domain of Midnolin as a New Glucokinase Interaction Partner by Hofmeister-Brix, Anke, Kollmann, Katrin, Langer, Sara, Schultz, Julia, Lenzen, Sigurd, Baltrusch, Simone

“…Glucokinase acts as a glucose sensor in pancreatic beta cells. Its posttranslational regulation is important but not yet fully understood. Therefore, a…”
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Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice by Reichart, Gesine, Mayer, Johannes, Zehm, Cindy, Kirschstein, Timo, Tokay, Tursonjan, Lange, Falko, Baltrusch, Simone, Tiedge, Markus, Fuellen, Georg, Ibrahim, Saleh, Köhling, Rüdiger

“…Aim Mitochondrial DNA (mtDNA) mutations can negatively influence lifespan and organ function. More than 250 pathogenic mtDNA mutations are known, often…”
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Real-time analysis of intracellular glucose and calcium in pancreatic beta cells by fluorescence microscopy by Kaminski, Martin Tobias, Lenzen, Sigurd, Baltrusch, Simone

“…Glucose is the physiological stimulus for insulin secretion in pancreatic beta cells. The uptake and phosphorylation of glucose initiate and control downstream…”
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MiD51 Is Important for Maintaining Mitochondrial Health in Pancreatic Islet and MIN6 Cells by Schultz, Julia, Warkus, Jeanette, Wolke, Carmen, Waterstradt, Rica, Baltrusch, Simone

“…Mitochondrial dynamics are important for glucose-stimulated insulin secretion in pancreatic beta cells. The mitochondrial elongation factor MiD51 has been…”
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Glucokinase Regulatory Network in Pancreatic β-Cells and Liver by BALTRUSCH, Simone, TIEDGE, Markus

“…Glucokinase Regulatory Network in Pancreatic β-Cells and Liver Simone Baltrusch 1 and Markus Tiedge 2 1 Institute of Clinical Biochemistry, Hannover Medical…”
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The Role of Neurotropic B Vitamins in Nerve Regeneration by Baltrusch, Simone

“…Damage and regeneration naturally occur in the peripheral nervous system. The neurotropic B vitamins thiamine (B1), pyridoxine (B6), and cobalamin (B12) are…”
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Diabetic foot syndrome and corneal subbasal nerve plexus changes in congolese patients with type 2 diabetes by Zhivov, Andrey, Peschel, Sabine, Schober, Hans-Christof, Stachs, Oliver, Baltrusch, Simone, Bambi, Marie Therese, Kilangalanga, Janvier, Winter, Karsten, Kundt, Guenther, Guthoff, Rudolf F

“…To study the severity of diabetic neuropathy, diabetic retinopathy and grades of diabetic foot syndrome for correlations with corneal subbasal nerve plexus…”
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Automated in‐depth fiber and nuclei typing in cross‐sectional muscle images can pave the way to a better understanding of skeletal muscle diseases by Baltrusch, Simone

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Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants by Mayer, Johannes, Reichart, Gesine, Tokay, Tursonjan, Lange, Falko, Baltrusch, Simone, Junghanss, Christian, Wolkenhauer, Olaf, Jaster, Robert, Kunz, Manfred, Tiedge, Markus, Ibrahim, Saleh, Fuellen, Georg, Köhling, Rüdiger

“…Large-scale, heteroplasmic and generally pathogenic mtDNA defects (as induced by defective mitochondrial DNA polymerase, clonal mutations or DNA deletions) are…”
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Novel Insights Into the Regulation of the Bound and Diffusible Glucokinase in MIN6 β-Cells by BALTRUSCH, Simone, LENZEN, Sigurd

“…Novel Insights Into the Regulation of the Bound and Diffusible Glucokinase in MIN6 β-Cells Simone Baltrusch and Sigurd Lenzen From the Institute of Clinical…”
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Mitochondrial network regulation and its potential interference with inflammatory signals in pancreatic beta cells by Baltrusch, Simone

“…Mitochondria fulfil multiple tasks in nutrient metabolism, energy production, redox homeostasis and stress response, and are essential for pancreatic beta cell…”
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Dimer interface rearrangement of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase rat liver isoenzyme by cAMP-dependent Ser-32 phosphorylation by Langer, Sara, Okar, David A., Schultz, Julia, Lenzen, Sigurd, Baltrusch, Simone

“…► Ser-32 phosphorylation reciprocally modulates the activities of liver PFK-2/FBPase-2. ► Dimerization of PFK-2/FBPase-2 was analyzed by fluorescence-based…”
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Interaction of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFK-2/FBPase-2) With Glucokinase Activates Glucose Phosphorylation and Glucose Metabolism in Insulin-Producing Cells by MASSA, Laura, BALTRUSCH, Simone, OKAR, David A, LANGE, Alex J, LENZEN, Sigurd, TIEDGE, Markus

“…Interaction of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFK-2/FBPase-2) With Glucokinase Activates Glucose Phosphorylation and Glucose Metabolism…”
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Interaction of Glucokinase With the Liver Regulatory Protein Is Conferred by Leucine-Asparagine Motifs of the Enzyme by BALTRUSCH, Simone, FRANCINI, Flavio, LENZEN, Sigurd, TIEDGE, Markus

“…Interaction of Glucokinase With the Liver Regulatory Protein Is Conferred by Leucine-Asparagine Motifs of the Enzyme Simone Baltrusch 1 , Flavio Francini 1 ,…”
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Glucokinase Is an Integral Component of the Insulin Granules in Glucose-Responsive Insulin Secretory Cells and Does Not Translocate During Glucose Stimulation by ARDEN, Catherine, HARBOTTLE, Andrew, BALTRUSCH, Simone, TIEDGE, Markus, AGIUS, Loranne

“…Glucokinase Is an Integral Component of the Insulin Granules in Glucose-Responsive Insulin Secretory Cells and Does Not Translocate During Glucose Stimulation…”
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Collagen Remodeling Plays a Pivotal Role in Endothelial Corneal Dystrophies by Walckling, Marcus, Waterstradt, Rica, Baltrusch, Simone

“…To elucidate the collagen structure in the Descemet membrane (DM) of the human cornea and to characterize its rearrangement in patients with endothelial…”
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Drp1 guarding of the mitochondrial network is important for glucose-stimulated insulin secretion in pancreatic beta cells by Reinhardt, Florian, Schultz, Julia, Waterstradt, Rica, Baltrusch, Simone

“…Mitochondria form a tubular network in mammalian cells, and the mitochondrial life cycle is determined by fission, fusion and autophagy. Dynamin-related…”
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The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells by Hofmeister-Brix, Anke, Lenzen, Sigurd, Baltrusch, Simone

“…The ubiquitin-proteasome system is important to maintain pancreatic β-cell function. Inhibition of the proteasome significantly reduced glucose-induced insulin…”
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