Search Results - "Baltissen, Marijke P."

High-throughput identification of human SNPs affecting regulatory element activity by van Arensbergen, Joris, Pagie, Ludo, FitzPatrick, Vincent D., de Haas, Marcel, Baltissen, Marijke P., Comoglio, Federico, van der Weide, Robin H., Teunissen, Hans, Võsa, Urmo, Franke, Lude, de Wit, Elzo, Vermeulen, Michiel, Bussemaker, Harmen J., van Steensel, Bas

“…Most of the millions of SNPs in the human genome are non-coding, and many overlap with putative regulatory elements. Genome-wide association studies (GWAS)…”
Get full text

Histone propionylation is a mark of active chromatin by Kebede, Adam F, Nieborak, Anna, Shahidian, Lara Zorro, Le Gras, Stephanie, Richter, Florian, Gómez, Diana Aguilar, Baltissen, Marijke P, Meszaros, Gergo, Magliarelli, Helena de Fatima, Taudt, Aaron, Margueron, Raphael, Colomé-Tatché, Maria, Ricci, Romeo, Daujat, Sylvain, Vermeulen, Michiel, Mittler, Gerhard, Schneider, Robert

“…Histone H3 lysine 14 is propionylated and butyrylated in vivo in a metabolic-state-dependent manner and these modifications promote high levels of…”
Get full text

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma by Brien, Gerard L, Remillard, David, Shi, Junwei, Hemming, Matthew L, Chabon, Jonathon, Wynne, Kieran, Dillon, Eugène T, Cagney, Gerard, Van Mierlo, Guido, Baltissen, Marijke P, Vermeulen, Michiel, Qi, Jun, Fröhling, Stefan, Gray, Nathanael S, Bradner, James E, Vakoc, Christopher R, Armstrong, Scott A

“…Synovial sarcoma tumours contain a characteristic fusion protein, SS18-SSX, which drives disease development. Targeting oncogenic fusion proteins presents an…”
Get full text

ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage by Spruijt, Cornelia G., Luijsterburg, Martijn S., Menafra, Roberta, Lindeboom, Rik G.H., Jansen, Pascal W.T.C., Edupuganti, Raghu Ram, Baltissen, Marijke P., Wiegant, Wouter W., Voelker-Albert, Moritz C., Matarese, Filomena, Mensinga, Anneloes, Poser, Ina, Vos, Harmjan R., Stunnenberg, Hendrik G., van Attikum, Haico, Vermeulen, Michiel

“…NuRD (nucleosome remodeling and histone deacetylase) is a versatile multi-protein complex with roles in transcription regulation and the DNA damage response…”
Get full text

The interactome of a family of potential methyltransferases in HeLa cells by Ignatova, Valentina V., Jansen, Pascal W. T. C., Baltissen, Marijke P., Vermeulen, Michiel, Schneider, Robert

“…Human methytransferase like proteins (METTL) are part of a large protein family characterized by the presence of binding domains for S-adenosyl methionine, a…”
Get full text

NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells by Kloet, Susan L., Karemaker, Ino D., van Voorthuijsen, Lisa, Lindeboom, Rik G. H., Baltissen, Marijke P., Edupuganti, Raghu R., Poramba-Liyanage, Deepani W., Jansen, Pascal W. T. C., Vermeulen, Michiel

“…The nucleosome remodeling and deacetylase (NuRD) complex plays an important role in gene expression regulation, stem cell self-renewal, and lineage commitment…”
Get full text

Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131 by Varier, Radhika A., de Santa Pau, Enrique Carrillo, van der Groep, Petra, Lindeboom, Rik G.H., Matarese, Filomena, Mensinga, Anneloes, Smits, Arne H., Edupuganti, Raghu Ram, Baltissen, Marijke P., Jansen, Pascal W.T.C., ter Hoeve, Natalie, van Weely, Danny R., Poser, Ina, van Diest, Paul J., Stunnenberg, Hendrik G., Vermeulen, Michiel

“…Recent work from others and us revealed interactions between the Sin3/HDAC complex, the H3K4me3 demethylase KDM5A, GATAD1, and EMSY. Here, we characterize the…”
Get full text

A central role for TFIID in the pluripotent transcription circuitry by Pijnappel, W. W. M. Pim, Esch, Daniel, Baltissen, Marijke P. A., Wu, Guangming, Mischerikow, Nikolai, Bergsma, Atze J., van der Wal, Erik, Han, Dong Wook, Bruch, Hermann vom, Moritz, Sören, Lijnzaad, Phillip, Altelaar, A. F. Maarten, Sameith, Katrin, Zaehres, Holm, Heck, Albert J. R., Holstege, Frank C. P., Schöler, Hans R., Timmers, H. T. Marc

“…High levels of TFIID, a basal transcription factor, are found to be essential to induce and maintain the transcriptional program of pluripotent cells. TFIID a…”
Get full text

N 6 -methyladenosine (m 6 A) recruits and repels proteins to regulate mRNA homeostasis by Edupuganti, Raghu R, Geiger, Simon, Lindeboom, Rik G H, Shi, Hailing, Hsu, Phillip J, Lu, Zhike, Wang, Shuang-Yin, Baltissen, Marijke P A, Jansen, Pascal W T C, Rossa, Martin, Müller, Markus, Stunnenberg, Hendrik G, He, Chuan, Carell, Thomas, Vermeulen, Michiel

“…RNA modifications are integral to the regulation of RNA metabolism. One abundant mRNA modification is N -methyladenosine (m A), which affects various aspects…”
Get full text

The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA by Pinto, Rita, Vågbø, Cathrine B, Jakobsson, Magnus E, Kim, Yeji, Baltissen, Marijke P, O’Donohue, Marie-Françoise, Guzmán, Ulises H, Małecki, Jędrzej M, Wu, Jie, Kirpekar, Finn, Olsen, Jesper V, Gleizes, Pierre-Emmanuel, Vermeulen, Michiel, Leidel, Sebastian A, Slupphaug, Geir, Falnes, Pål Ø

“…Abstract RNA methylations are essential both for RNA structure and function, and are introduced by a number of distinct methyltransferases (MTases). In recent…”
Get full text

Proteomic landscape of the primary somatosensory cortex upon sensory deprivation by Kole, Koen, Lindeboom, Rik G.H., Baltissen, Marijke P.A., Jansen, Pascal W.T.C., Vermeulen, Michiel, Tiesinga, Paul, Celikel, Tansu

“…Abstract Experience-dependent plasticity (EDP) powerfully shapes neural circuits by inducing long-lasting molecular changes in the brain. Molecular mechanisms…”
Get full text

Cross‐linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex by Spruijt, Cornelia G., Gräwe, Cathrin, Kleinendorst, Simone C., Baltissen, Marijke P. A., Vermeulen, Michiel

“…Thorough purification and cross‐linking of the NuRD complex from multiple angles led to a high‐density interaction network. The core is formed by MTA‐HDAC and…”
Get full text

Actin maturation requires the ACTMAP/C19orf54 protease by Haahr, Peter, Galli, Ricardo A., van den Hengel, Lisa G., Bleijerveld, Onno B., Kazokaitė-Adomaitienė, Justina, Song, Ji-Ying, Kroese, Lona J., Krimpenfort, Paul, Baltissen, Marijke P., Vermeulen, Michiel, Ottenheijm, Coen A. C., Brummelkamp, Thijn R.

“…Protein synthesis generally starts with a methionine that is removed during translation. However, cytoplasmic actin defies this rule because its synthesis…”
Get full text

Quantification of absolute transcription factor binding affinities in the native chromatin context using BANC-seq by Neikes, Hannah K., Kliza, Katarzyna W., Gräwe, Cathrin, Wester, Roelof A., Jansen, Pascal W. T. C., Lamers, Lieke A., Baltissen, Marijke P., van Heeringen, Simon J., Logie, Colin, Teichmann, Sarah A., Lindeboom, Rik G. H., Vermeulen, Michiel

“…Transcription factor binding across the genome is regulated by DNA sequence and chromatin features. However, it is not yet possible to quantify the impact of…”
Get full text

Seasonal variation in BCG-induced trained immunity by Kilic, Gizem, Debisarun, Priya A., Alaswad, Ahmed, Baltissen, Marijke P., Lamers, Lieke A., de Bree, L. Charlotte J., Benn, Christine S., Aaby, Peter, Dijkstra, Helga, Lemmers, Heidi, Martens, Joost H.A., Domínguez-Andrés, Jorge, van Crevel, Reinout, Li, Yang, Xu, Cheng-Jian, Netea, Mihai G.

“…The Bacille Calmette-Guerin (BCG) vaccine is a well-established inducer of innate immune memory (also termed trained immunity), causing increased cytokine…”
Get full text

Selective Anchoring of TFIID to Nucleosomes by Trimethylation of Histone H3 Lysine 4 by Vermeulen, Michiel, Mulder, Klaas W., Denissov, Sergei, Pijnappel, W.W.M.Pim, van Schaik, Frederik M.A., Varier, Radhika A., Baltissen, Marijke P.A., Stunnenberg, Henk G., Mann, Matthias, Timmers, H.Th.Marc

“…Trimethylation of histone H3 at lysine 4 (H3K4me3) is regarded as a hallmark of active human promoters, but it remains unclear how this posttranslational…”
Get full text

Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics by Stelloo, Suzan, Alejo-Vinogradova, Maria Teresa, van Gelder, Charlotte A G H, Zijlmans, Dick W, van Oostrom, Marek J, Valverde, Juan Manuel, Lamers, Lieke A, Rus, Teja, Sobrevals Alcaraz, Paula, Schäfers, Tilman, Furlan, Cristina, Jansen, Pascal W T C, Baltissen, Marijke P A, Sonnen, Katharina F, Burgering, Boudewijn, Altelaar, Maarten A F M, Vos, Harmjan R, Vermeulen, Michiel

“…Gastrulation is a critical stage in embryonic development during which the germ layers are established. Advances in sequencing technologies led to the…”
Get more information

Functional annotation and investigation of the 10q24.33 melanoma risk locus identifies a common variant that influences transcriptional regulation of OBFC1 by Cardinale, Antonella, Cantalupo, Sueva, Lasorsa, Vito Alessandro, Montella, Annalaura, Cimmino, Flora, Succoio, Mariangela, Vermeulen, Michiel, Baltissen, Marijke P, Esposito, Matteo, Avitabile, Marianna, Formicola, Daniela, Testori, Alessandro, Bonfiglio, Ferdinando, Ghiorzo, Paola, Scalvenzi, Massimiliano, Ayala, Fabrizio, Zambrano, Nicola, Iles, Mark M, Xu, Mai, Law, Matthew H, Brown, Kevin M, Iolascon, Achille, Capasso, Mario

“…Abstract The 10q24.33 locus is known to be associated with susceptibility to cutaneous malignant melanoma (CMM), but the mechanisms underlying this association…”
Get full text

Chromosomal instability by mutations in the novel minor spliceosome component CENATAC by de Wolf, Bas, Oghabian, Ali, Akinyi, Maureen V, Hanks, Sandra, Tromer, Eelco C, van Hooff, Jolien J E, van Voorthuijsen, Lisa, van Rooijen, Laura E, Verbeeren, Jens, Uijttewaal, Esther C H, Baltissen, Marijke P A, Yost, Shawn, Piloquet, Philippe, Vermeulen, Michiel, Snel, Berend, Isidor, Bertrand, Rahman, Nazneen, Frilander, Mikko J, Kops, Geert J P L

“…Aneuploidy is the leading cause of miscarriage and congenital birth defects, and a hallmark of cancer. Despite this strong association with human disease, the…”
Get full text

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity by Baars, Matthijs J.D., Douma, Thera, Simeonov, Dimitre R., Myers, Darienne R., Kulhanek, Kayla, Banerjee, Saikat, Zwakenberg, Susan, Baltissen, Marijke P., Amini, Mojtaba, Roock, Sytze, Wijk, Femke, Vermeulen, Michiel, Marson, Alexander, Roose, Jeroen P., Vercoulen, Yvonne

“…RasGRP1 is a Ras guanine nucleotide exchange factor, and an essential regulator of lymphocyte receptor signaling. In mice, Rasgrp1 deletion results in…”
Get full text