Search Results - "Balthasar, Nina"

Sexual Dimorphism in Offspring Glucose-Sensitive Hypothalamic Gene Expression and Physiological Responses to Maternal High-Fat Diet Feeding by Dearden, Laura, Balthasar, Nina

“…A wealth of animal and human studies demonstrate that early life environment significantly influences adult metabolic balance, however the etiology for…”
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Genetic Dissection of Neuronal Pathways Controlling Energy Homeostasis by Balthasar, Nina

“…Recent research has identified a number of genes playing critical roles in the central regulation of energy homeostasis. Subsequently, models of the…”
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Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis by Rossi, Jari, Balthasar, Nina, Olson, David, Scott, Michael, Berglund, Eric, Lee, Charlotte E., Choi, Michelle J., Lauzon, Danielle, Lowell, Bradford B., Elmquist, Joel K.

“…Melanocortin-4 receptor (MC4R) mutations cause dysregulation of energy balance and hyperinsulinemia. We have used mouse models to study the physiological roles…”
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Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network by McHugh, Thomas J, Jones, Matthew W, Quinn, Jennifer J, Balthasar, Nina, Coppari, Roberto, Elmquist, Joel K, Lowell, Bradford B, Fanselow, Michael S, Wilson, Matthew A, Tonegawa, Susumu

“…Forming distinct representations of multiple contexts, places, and episodes is a crucial function of the hippocampus. The dentate gyrus subregion has been…”
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Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea by Cerritelli, Serena, Hirschberg, Stefan, Hill, Rob, Balthasar, Nina, Pickering, Anthony E

“…Opioids are widely used medicinally as analgesics and abused for hedonic effects, actions that are each complicated by substantial risks such as…”
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Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons by Sohn, Jong-Woo, Harris, Louise E., Berglund, Eric D., Liu, Tiemin, Vong, Linh, Lowell, Bradford B., Balthasar, Nina, Williams, Kevin W., Elmquist, Joel K.

“…Melanocortin 4 receptors (MC4Rs) in the central nervous system are key regulators of energy and glucose homeostasis. Notably, obese patients with MC4R…”
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Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice by Hill, Jennifer W, Williams, Kevin W, Ye, Chianping, Luo, Ji, Balthasar, Nina, Coppari, Roberto, Cowley, Michael A, Cantley, Lewis C, Lowell, Bradford B, Elmquist, Joel K

“…Normal food intake and body weight homeostasis require the direct action of leptin on hypothalamic proopiomelanocortin (POMC) neurons. It has been proposed…”
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Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum by Higley, Michael J, Gittis, Aryn H, Oldenburg, Ian A, Balthasar, Nina, Seal, Rebecca P, Edwards, Robert H, Lowell, Bradford B, Kreitzer, Anatol C, Sabatini, Bernardo L

“…The neurotransmitter glutamate is released by excitatory projection neurons throughout the brain. However, non-glutamatergic cells, including cholinergic and…”
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Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis by Elmquist, Joel K., Coppari, Roberto, Balthasar, Nina, Ichinose, Masumi, Lowell, Bradford B.

“…The past decade has greatly increased our understanding and appreciation of the ability of the central nervous system (CNS) to regulate food intake and body…”
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CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease by Weir, Heather J M, Murray, Tracey K, Kehoe, Patrick G, Love, Seth, Verdin, Eric M, O'Neill, Michael J, Lane, Jon D, Balthasar, Nina

“…Progressive mitochondrial dysfunction contributes to neuronal degeneration in age-mediated disease. An essential regulator of mitochondrial function is the…”
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Feeding signals to the hungry mind by Balthasar, Nina

“…Obesity, due to its associated co-morbidities, including type 2 diabetes and cardiovascular disease, is at the forefront of today's health care concerns. Our…”
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Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis by Balthasar, Nina, Coppari, Roberto, McMinn, Julie, Liu, Shun M, Lee, Charlotte E, Tang, Vinsee, Kenny, Christopher D, McGovern, Robert A, Chua, Streamson C, Elmquist, Joel K, Lowell, Bradford B

“…Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the…”
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Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure by Balthasar, Nina, Dalgaard, Louise T., Lee, Charlotte E., Yu, Jia, Funahashi, Hisayuki, Williams, Todd, Ferreira, Manuel, Tang, Vinsee, McGovern, Robert A., Kenny, Christopher D., Christiansen, Lauryn M., Edelstein, Elizabeth, Choi, Brian, Boss, Olivier, Aschkenasi, Carl, Zhang, Chen-yu, Mountjoy, Kathleen, Kishi, Toshiro, Elmquist, Joel K., Lowell, Bradford B.

“…Activation of melanocortin-4-receptors (MC4Rs) reduces body fat stores by decreasing food intake and increasing energy expenditure. MC4Rs are expressed in…”
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Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion by van de Wall, Esther, Leshan, Rebecca, Xu, Allison W, Balthasar, Nina, Coppari, Roberto, Liu, Shun Mei, Jo, Young Hwan, MacKenzie, Robert G, Allison, David B, Dun, Nae J, Elmquist, Joel, Lowell, Bradford B, Barsh, Gregory S, de Luca, Carl, Myers, Martin G, Schwartz, Gary J, Chua, Streamson C

“…Two known types of leptin-responsive neurons reside within the arcuate nucleus: the agouti gene-related peptide (AgRP)/neuropeptide Y (NPY) neuron and the…”
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Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake by Heisler, Lora K., Jobst, Erin E., Sutton, Gregory M., Zhou, Ligang, Borok, Erzsebet, Thornton-Jones, Zoe, Liu, Hong Yan, Zigman, Jeffrey M., Balthasar, Nina, Kishi, Toshiro, Lee, Charlotte E., Aschkenasi, Carl J., Zhang, Chen-Yu, Yu, Jia, Boss, Olivier, Mountjoy, Kathleen G., Clifton, Peter G., Lowell, Bradford B., Friedman, Jeffrey M., Horvath, Tamas, Butler, Andrew A., Elmquist, Joel K., Cowley, Michael A.

“…The neural pathways through which central serotonergic systems regulate food intake and body weight remain to be fully elucidated. We report that serotonin,…”
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Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells by Kievit, Paul, Howard, Jane K., Badman, Michael K., Balthasar, Nina, Coppari, Roberto, Mori, Hiroyuki, Lee, Charlotte E., Elmquist, Joel K., Yoshimura, Akihiko, Flier, Jeffrey S.

“…Suppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of various cytokines, as well as the metabolic hormones leptin and insulin. Mice…”
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Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis by Hill, Jennifer W, Xu, Yong, Preitner, Frederic, Fukuda, Makota, Cho, You-Ree, Luo, Ji, Balthasar, Nina, Coppari, Roberto, Cantley, Lewis C, Kahn, Barbara B, Zhao, Jean J, Elmquist, Joel K

“…Recent studies demonstrated a role for hypothalamic insulin and leptin action in the regulation of glucose homeostasis. This regulation involves…”
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Physiological Studies of Transgenic Mice Overexpressing Growth Hormone (GH) Secretagogue Receptor 1A in GH-Releasing Hormone Neurons by Lall, Sabrina, Balthasar, Nina, Carmignac, Danielle, Magoulas, Charamboulos, Sesay, Abdul, Houston, Pamela, Mathers, Kathleen, Robinson, Iain

“…The type 1A GH secretagogue (GHS) receptor (GHSR) has been proposed to mediate the effects of ghrelin on GH release, food intake, and body composition. We have…”
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The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits by Li, Monica M., Madara, Joseph C., Steger, Jennifer S., Krashes, Michael J., Balthasar, Nina, Campbell, John N., Resch, Jon M., Conley, Nicholas J., Garfield, Alastair S., Lowell, Bradford B.

“…SIM1-expressing paraventricular hypothalamus (PVH) neurons are key regulators of energy balance. Within the PVHSIM1 population, melanocortin-4…”
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Agouti-related peptide-expressing neurons are mandatory for feeding by Horvath, Tamas L, Brüning, Jens C, Gropp, Eva, Shanabrough, Marya, Borok, Erzsebet, Xu, Allison W, Janoschek, Ruth, Buch, Thorsten, Plum, Leona, Balthasar, Nina, Hampel, Brigitte, Waisman, Ari, Barsh, Gregory S

“…Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of…”
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