Search Results - "Balogh, Balázs"
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Advantages of Induced Circular Dichroism Spectroscopy for Qualitative and Quantitative Analysis of Solution-Phase Cyclodextrin Host-Guest Complexes
Published in International journal of molecular sciences (28-12-2023)“…The presence of a chiral or chirally perturbed chromophore in the molecule under investigation is a fundamental requirement for the appearance of a circular…”
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Sustainable and Safe N -alkylation of N -heterocycles by Propylene Carbonate under Neat Reaction Conditions
Published in International journal of molecular sciences (18-05-2024)“…A new, eco-friendly process utilising the green solvent propylene carbonate (PC) has been developed to perform -alkylation of -, - and/or -containing…”
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3
Molecular Dynamics Simulations of Drug-Conjugated Cell-Penetrating Peptides
Published in Pharmaceuticals (Basel, Switzerland) (01-09-2023)“…Cell-penetrating peptides (CPPs) are small peptides capable of translocating through biological membranes carrying various attached cargo into cells and even…”
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4
Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches
Published in Molecules (Basel, Switzerland) (09-10-2019)“…The complement system is associated with various diseases such as inflammation or auto-immune diseases. Complement-targeted drugs could provide novel…”
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5
Drug repositioning for treatment of movement disorders: from serendipity to rational discovery strategies
Published in Current topics in medicinal chemistry (01-09-2013)“…Movement disorders are a heterogeneous group of both common and rare neurological conditions characterized by abnormalities of motor functions and movement…”
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Small Molecules as Toll-like Receptor 4 Modulators Drug and In-House Computational Repurposing
Published in Biomedicines (19-09-2022)“…The innate immunity toll-like receptor 4 (TLR4) system is a receptor of paramount importance as a therapeutic target. Virtual screening following a…”
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Preparation of neuroprotective condensed 1,4-benzoxazepines by regio- and diastereoselective domino Knoevenagel-[1,5]-hydride shift cyclization reaction
Published in Beilstein journal of organic chemistry (06-11-2014)“…Condensed O,N-heterocycles containing tetrahydro-1,4-benzoxazepine and tetrahydroquinoline moieties were prepared by a regio- and diastereoselective domino…”
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Cheetah conservation in the Horn of Africa – notes and thoughts in the light of field experiences
Published in Afrika tanulmányok (Online) (15-06-2024)“…The future of many of the emblematic species of the African continent is facing enormous challenges in our modern, tumultuous world. Yet, there is a growing…”
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ConjuPepDB: a database of peptide–drug conjugates
Published in Nucleic acids research (08-01-2021)“…Abstract Peptide–drug conjugates are organic molecules composed of (i) a small drug molecule, (ii) a peptide and (iii) a linker. The drug molecule is mandatory…”
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10
GraphCPP: The new state‐of‐the‐art method for cell‐penetrating peptide prediction via graph neural networks
Published in British journal of pharmacology (20-11-2024)“…Cell-penetrating peptides (CPPs) are short amino acid sequences that can penetrate cell membranes and deliver molecules into cells. Several models have been…”
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Novel Arylalkenylpropargylamines as Neuroprotective, Potent, and Selective Monoamine Oxidase B Inhibitors for the Treatment of Parkinson’s Disease
Published in Journal of medicinal chemistry (12-02-2015)“…To develop novel neuroprotective agents, a library of novel arylalkenylpropargylamines was synthesized and tested for inhibitory activities against monoamine…”
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Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action
Published in European journal of medicinal chemistry (13-04-2015)“…Water-soluble isoindoloquinoxalin (IIQ) imines and the corresponding acetates were conveniently prepared from the key intermediates…”
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Szafarivezetőként Dél-Afrikában: Személyes tapasztalatok az ökoturizmus kínálati oldalán
Published in Afrika tanulmányok (Online) (20-10-2024)“…A Dél-afrikai Köztársaság gazdaságának egyik legfontosabb pillérévé mára az ökoturizmus, ezen belül is - flórájának és faunájának adottságait kihasználva - a…”
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Piceatannol and resveratrol share inhibitory effects on hydrogen peroxide release, monoamine oxidase and lipogenic activities in adipose tissue, but differ in their antilipolytic properties
Published in Chemico-biological interactions (25-10-2016)“…Piceatannol is a hydroxylated derivative of resveratrol. While both dietary polyphenols coexist in edible plants and fruits, and share equivalent…”
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Analysis of Edg-Like LPA Receptor-Ligand Interactions
Published in Current pharmaceutical design (01-01-2015)“…The phospholipid derivative lysophosphatidic acid (LPA) serves as a signalling molecule through the activation of LPA receptors, which belong to the…”
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Sustainable and Safe IN/I-alkylation of IN/I-heterocycles by Propylene Carbonate under Neat Reaction Conditions
Published in International journal of molecular sciences (01-05-2024)“…A new, eco-friendly process utilising the green solvent propylene carbonate (PC) has been developed to perform N-alkylation of N-, O- and/or S-containing…”
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17
Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1: a patent survey
Published in Expert opinion on therapeutic patents (01-09-2011)“…Vascular adhesion protein-1 (VAP-1)/semicarbazide-sensitive amine oxidase (SSAO) is an adhesion protein involved in leukocyte trafficking and inflammatory…”
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Dietary Phenolic Compounds Interfere with the Fate of Hydrogen Peroxide in Human Adipose Tissue but Do Not Directly Inhibit Primary Amine Oxidase Activity
Published in Oxidative medicine and cellular longevity (01-01-2016)“…Resveratrol has been reported to inhibit monoamine oxidases (MAO). Many substrates or inhibitors of neuronal MAO interact also with other amine oxidases (AO)…”
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Investigation of Isoindolo[2,1-a]quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods
Published in Current computer-aided drug design (01-09-2017)“…Isoindolo[2,1-a]quinoxalines constitute an important class of compounds which demonstrated potent antiproliferative activity against different human tumor cell…”
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Molecular modelling of subtypes (alpha(2A), alpha(2B) and alpha(2C)) of alpha(2)-adrenoceptors: a comparative study
Published in Neurochemistry international (01-11-2009)“…The therapeutic usefulness of current agents that activate the three alpha(2)-adrenoceptors, alpha(2A), alpha(2B) and alpha(2C) is limited by their lack of…”
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