Bioadhesive Controlled Release Systems of Ornidazole for Vaginal Delivery

Our objective was to develop a bioadhesive vaginal tablet formulation of ornidazole by using different polymer mixtures, to evaluate the bioadhesive tablet properties, and to investigate the irritation potential of the formulations to the rat vaginal tissue. Vaginal tablets of ornidazole were direct...

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Bibliographic Details
Published in:	Pharmaceutical development and technology Vol. 11; no. 4; pp. 477 - 484
Main Authors:	Balo lu, Esra, Özyaz c, Mine, Yaprak H zarc o lu, Sinem, enyi it, Taner, Özyurt, Do an, Pekçetin, Cetin
Format:	Journal Article
Language:	English
Published:	New York, NY Informa UK Ltd 01-01-2006 Taylor & Francis Informa Healthcare
Subjects:	Adhesiveness Administration, Intravaginal Animals bioadhesion Biological and medical sciences Biomechanical Phenomena carbopol 934 Cattle Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics General pharmacology Medical sciences Models, Theoretical ornidazole Ornidazole - pharmacokinetics Ornidazole - therapeutic use Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics Pharmacology. Drug treatments Polymers - pharmacokinetics Polymers - therapeutic use Rats Solubility swelling-controlled Tablets vaginal tablet Wettability Nitro compound Imidazole derivatives Bioadhesion Pharmaceutical technology Intravaginal administration Swelling Controlled release form Ornidazole carbopol 934 Antiprotozoal agent Dosage form Parasiticide Tablet swelling- controlled vaginal tablet Bioadhesive system
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Summary:	Our objective was to develop a bioadhesive vaginal tablet formulation of ornidazole by using different polymer mixtures, to evaluate the bioadhesive tablet properties, and to investigate the irritation potential of the formulations to the rat vaginal tissue. Vaginal tablets of ornidazole were directly compressed with bioadhesive and swellable polymer mixtures as release-controlled agents. Carbopol 934 (Cp), pectin (Pc), hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose (Na CMC), and guar gum (GG) were used in different ratios. Bioadhesive properties, swelling capacity, release studies, and histological studies of the formulations were carried out. The bioadhesive strength between bovine vagina and surface of the tablets was determined by tensile experiments, and it was found to be dependent on Cp content. The release mechanism was described and found to be non-Fickian for all formulations. Dissolution data were evaluated statistically. No histological damage was found except one formulation containing high amount of guar gum.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1083-7450 1097-9867
DOI:	10.1080/10837450600939784