Search Results - "Balloux, Francois"

Large-scale network analysis captures biological features of bacterial plasmids by Acman, Mislav, van Dorp, Lucy, Santini, Joanne M., Balloux, Francois

“…Many bacteria can exchange genetic material through horizontal gene transfer (HGT) mediated by plasmids and plasmid-borne transposable elements. Here, we study…”
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Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM by Acman, Mislav, Wang, Ruobing, van Dorp, Lucy, Shaw, Liam P., Wang, Qi, Luhmann, Nina, Yin, Yuyao, Sun, Shijun, Chen, Hongbin, Wang, Hui, Balloux, Francois

“…The mobile resistance gene bla NDM encodes the NDM enzyme which hydrolyses carbapenems, a class of antibiotics used to treat some of the most severe bacterial…”
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Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast by Jeffares, Daniel C., Jolly, Clemency, Hoti, Mimoza, Speed, Doug, Shaw, Liam, Rallis, Charalampos, Balloux, Francois, Dessimoz, Christophe, Bähler, Jürg, Sedlazeck, Fritz J.

“…Large structural variations (SVs) within genomes are more challenging to identify than smaller genetic variants but may substantially contribute to phenotypic…”
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The global distribution and spread of the mobilized colistin resistance gene mcr-1 by Wang, Ruobing, van Dorp, Lucy, Shaw, Liam P., Bradley, Phelim, Wang, Qi, Wang, Xiaojuan, Jin, Longyang, Zhang, Qing, Liu, Yuqing, Rieux, Adrien, Dorai-Schneiders, Thamarai, Weinert, Lucy Anne, Iqbal, Zamin, Didelot, Xavier, Wang, Hui, Balloux, Francois

“…Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae . As such, the recent…”
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Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain by Eldholm, Vegard, Monteserin, Johana, Rieux, Adrien, Lopez, Beatriz, Sobkowiak, Benjamin, Ritacco, Viviana, Balloux, Francois

“…The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in…”
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Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene bla NDM by Mislav Acman, Ruobing Wang, Lucy van Dorp, Liam P. Shaw, Qi Wang, Nina Luhmann, Yuyao Yin, Shijun Sun, Hongbin Chen, Hui Wang, Francois Balloux

“…Gene bla NDM, conferring resistance to carbapenem antibiotics, is globally distributed across Gram-negative bacteria on multiple plasmids. Here, Acman et al…”
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Modelling microbiome recovery after antibiotics using a stability landscape framework by Shaw, Liam P., Bassam, Hassan, Barnes, Chris P., Walker, A. Sarah, Klein, Nigel, Balloux, Francois

“…Treatment with antibiotics is one of the most extreme perturbations to the human microbiome. Even standard courses of antibiotics dramatically reduce the…”
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Genomic signatures of pre-resistance in Mycobacterium tuberculosis by Torres Ortiz, Arturo, Coronel, Jorge, Vidal, Julia Rios, Bonilla, Cesar, Moore, David A. J., Gilman, Robert H., Balloux, Francois, Kon, Onn Min, Didelot, Xavier, Grandjean, Louis

“…Recent advances in bacterial whole-genome sequencing have resulted in a comprehensive catalog of antibiotic resistance genomic signatures in Mycobacterium…”
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Oral microbiomes from hunter‐gatherers and traditional farmers reveal shifts in commensal balance and pathogen load linked to diet by Lassalle, Florent, Spagnoletti, Matteo, Fumagalli, Matteo, Shaw, Liam, Dyble, Mark, Walker, Catherine, Thomas, Mark G., Bamberg Migliano, Andrea, Balloux, Francois

“…Maladaptation to modern diets has been implicated in several chronic disorders. Given the higher prevalence of disease such as dental caries and chronic gum…”
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Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings by Fraser, Christophe, Donnelly, Christl A, Cauchemez, Simon, Hanage, William P, Van Kerkhove, Maria D, Hollingsworth, T. Déirdre, Griffin, Jamie, Baggaley, Rebecca F, Jenkins, Helen E, Lyons, Emily J, Jombart, Thibaut, Hinsley, Wes R, Grassly, Nicholas C, Balloux, Francois, Ghani, Azra C, Ferguson, Neil M, Rambaut, Andrew, Pybus, Oliver G, Lopez-Gatell, Hugo, Alpuche-Aranda, Celia M, Chapela, Ietza Bojorquez, Zavala, Ethel Palacios, Guevara, Dulce Ma. Espejo, Checchi, Francesco, Garcia, Erika, Hugonnet, Stephane, Roth, Cathy

“…A novel influenza A (H1N1) virus has spread rapidly across the globe. Judging its pandemic potential is difficult with limited data, but nevertheless essential…”
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Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis by Cui, Yujun, Yu, Chang, Yan, Yanfeng, Li, Dongfang, Li, Yanjun, Jombart, Thibaut, Weinert, Lucy A., Wang, Zuyun, Guo, Zhaobiao, Xu, Lizhi, Zhang, Yujiang, Zheng, Hancheng, Qin, Nan, Xiao, Xiao, Wu, Mingshou, Wang, Xiaoyi, Zhou, Dongsheng, Qi, Zhizhen, Du, Zongmin, Wu, Honglong, Yang, Xianwei, Cao, Hongzhi, Wang, Hu, Wang, Jing, Yao, Shusen, Rakin, Alexander, Li, Yingrui, Falush, Daniel, Balloux, Francois, Achtman, Mark, Song, Yajun, Wang, Jun, Yang, Ruifu

“…The genetic diversity of Yersinia pestis , the etiologic agent of plague, is extremely limited because of its recent origin coupled with a slow clock rate…”
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Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture by Nimmo, Camus, Shaw, Liam P, Doyle, Ronan, Williams, Rachel, Brien, Kayleen, Burgess, Carrie, Breuer, Judith, Balloux, Francois, Pym, Alexander S

“…Repeated culture reduces within-sample Mycobacterium tuberculosis genetic diversity due to selection of clones suited to growth in culture and/or random loss…”
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Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain by van Dorp, Lucy, Gelabert, Pere, Rieux, Adrien, de Manuel, Marc, de-Dios, Toni, Gopalakrishnan, Shyam, Carøe, Christian, Sandoval-Velasco, Marcela, Fregel, Rosa, Olalde, Iñigo, Escosa, Raül, Aranda, Carles, Huijben, Silvie, Mueller, Ivo, Marquès-Bonet, Tomàs, Balloux, François, Gilbert, M Thomas P, Lalueza-Fox, Carles

“…The protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and…”
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Multiple emergences of genetically diverse amphibian-infecting chytrids include a globalized hypervirulent recombinant lineage by Farrer, Rhys A, Weinert, Lucy A, Bielby, Jon, Garner, Trenton W. J, Balloux, Francois, Clare, Frances, Bosch, Jaime, Cunningham, Andrew A, Weldon, Che, du Preez, Louis H, Anderson, Lucy, Pond, Sergei L. Kosakovsky, Shahar-Golan, Revital, Henk, Daniel A, Fisher, Matthew C

“…Batrachochytrium dendrobatidis (Bd) is a globally ubiquitous fungal infection that has emerged to become a primary driver of amphibian biodiversity loss…”
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Increase in antioxidant capacity associated with the successful subclone of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11-KL64 by Wang, Ruobing, Zhang, Anru, Sun, Shijun, Yin, Guankun, Wu, Xingyu, Ding, Qi, Wang, Qi, Chen, Fengning, Wang, Shuyi, van Dorp, Lucy, Zhang, Yawei, Jin, Longyang, Wang, Xiaojuan, Balloux, Francois, Wang, Hui

“…The acquisition of exogenous mobile genetic material imposes an adaptive burden on bacteria, whereas the adaptational evolution of virulence plasmids upon…”
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The Human Salivary Microbiome Is Shaped by Shared Environment Rather than Genetics: Evidence from a Large Family of Closely Related Individuals by Shaw, Liam, Ribeiro, Andre L R, Levine, Adam P, Pontikos, Nikolas, Balloux, Francois, Segal, Anthony W, Roberts, Adam P, Smith, Andrew M

“…The human microbiome is affected by multiple factors, including the environment and host genetics. In this study, we analyzed the salivary microbiomes of an…”
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Late Pleistocene climate change and the global expansion of anatomically modern humans by Eriksson, Anders, Betti, Lia, Friend, Andrew D, Lycett, Stephen J, Singarayer, Joy S, von Cramon-Taubadel, Noreen, Valdes, Paul J, Balloux, Francois, Manica, Andrea

“…The extent to which past climate change has dictated the pattern and timing of the out-of-Africa expansion by anatomically modern humans is currently unclear…”
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A timescale for evolution, population expansion, and spatial spread of an emerging clone of methicillin-resistant Staphylococcus aureus by Nübel, Ulrich, Dordel, Janina, Kurt, Kevin, Strommenger, Birgit, Westh, Henrik, Shukla, Sanjay K, Zemlicková, Helena, Leblois, Raphaël, Wirth, Thierry, Jombart, Thibaut, Balloux, François, Witte, Wolfgang

“…Due to the lack of fossil evidence, the timescales of bacterial evolution are largely unknown. The speed with which genetic change accumulates in populations…”
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Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis by Eldholm, Vegard, Rieux, Adrien, Monteserin, Johana, Lopez, Julia Montana, Palmero, Domingo, Lopez, Beatriz, Ritacco, Viviana, Didelot, Xavier, Balloux, Francois

“…The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has…”
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Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis by Nimmo, Camus, Ortiz, Arturo Torres, Tan, Cedric C S, Pang, Juanita, Acman, Mislav, Millard, James, Padayatchi, Nesri, Grant, Alison D, O'Donnell, Max, Pym, Alex, Brynildsrud, Ola B, Eldholm, Vegard, Grandjean, Louis, Didelot, Xavier, Balloux, François, van Dorp, Lucy

“…Drug resistance in tuberculosis (TB) poses a major ongoing challenge to public health. The recent inclusion of bedaquiline into TB drug regimens has improved…”
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