Search Results - "Ballotti, R."

Pathways from senescence to melanoma: focus on MITF sumoylation by Leclerc, J, Ballotti, R, Bertolotto, C

“…Cutaneous melanoma is a deadly skin cancer that originates from melanocytes. The development of cutaneous melanoma involves a complex interaction between…”
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Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma by Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

“…Malignant melanoma is an aggressive cancer known for its notorious resistance to most current therapies. The basic helix-loop-helix microphthalmia…”
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Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny by Cheli, Y, Guiliano, S, Botton, T, Rocchi, S, Hofman, V, Hofman, P, Bahadoran, P, Bertolotto, C, Ballotti, R

“…In melanoma, as well as in other solid tumors, the cells within a given tumor exhibit strong morphological, functional and molecular heterogeneity that might…”
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Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells by Cheli, Y, Giuliano, S, Fenouille, N, Allegra, M, Hofman, V, Hofman, P, Bahadoran, P, Lacour, J-P, Tartare-Deckert, S, Bertolotto, C, Ballotti, R

“…Melanomas are very aggressive neoplasms with notorious resistance to therapeutics. It was recently proposed that the remarkable phenotypic plasticity of…”
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Metformin inhibits melanoma development through autophagy and apoptosis mechanisms by Tomic, T, Botton, T, Cerezo, M, Robert, G, Luciano, F, Puissant, A, Gounon, P, Allegra, M, Bertolotto, C, Bereder, J-M, Tartare-Deckert, S, Bahadoran, P, Auberger, P, Ballotti, R, Rocchi, S

“…Metformin is the most widely used antidiabetic drug because of its proven efficacy and limited secondary effects. Interestingly, recent studies have reported…”
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SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival by Fenouille, N, Puissant, A, Tichet, M, Zimniak, G, Abbe, P, Mallavialle, A, Rocchi, S, Ortonne, J-P, Deckert, M, Ballotti, R, Tartare-Deckert, S

“…Aberrant expression of Secreted Protein Acidic and Rich in Cysteine (SPARC)/osteonectin has been associated with an invasive tumor cell phenotype and poor…”
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Metformin inhibits melanoma development through autophagy and apoptosis mechanisms by Tomic, T, Botton, T, Cerezo, M, Robert, G, Luciano, F, Puissant, A, Gounon, P, Allegra, M, Bertolotto, C, Bereder, J-M, Tartare-Deckert, S, Bahadoran, P, Auberger, P, Ballotti, R, Rocchi, S

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NF-kB2 induces senescence bypass in melanoma via a direct transcriptional activation of EZH2 by De Donatis, G M, Le Pape, E, Pierron, A, Cheli, Y, Hofman, V, Hofman, P, Allegra, M, Zahaf, K, Bahadoran, P, Rocchi, S, Bertolotto, C, Ballotti, R, Passeron, T

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Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth by Botton, T, Puissant, A, Cheli, Y, Tomic, T, Giuliano, S, Fajas, L, Deckert, M, Ortonne, J-P, Bertolotto, C, Tartare-Deckert, S, Ballotti, R, Rocchi, S

“…We have previously demonstrated that the thiazolidinedione ciglitazone inhibited, independently of PPAR γ activation, melanoma cell growth. Further…”
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NF-kB2 induces senescence bypass in melanoma via a direct transcriptional activation of EZH2 by De Donatis, G M, Pape, E L, Pierron, A, Cheli, Y, Hofman, V, Hofman, P, Allegra, M, Zahaf, K, Bahadoran, P, Rocchi, S, Bertolotto, C, Ballotti, R, Passeron, T

“…Enhancer of Zeste homologue 2 (EZH2) belongs to the polycomb repressive complex 2 and catalyzes the methylation of histone H3 lysine 27. These pivotal…”
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Regulation of the Microphthalmia-associated Transcription Factor Gene by the Waardenburg Syndrome Type 4 Gene,SOX10 by Verastegui, Carole, Bille, Karine, Ortonne, Jean-Paul, Ballotti, Robert

“…The absence of melanocytes from the cochlea and epidermis is responsible of deafness and hypopigmentation, two symptoms shared by the four Waardenburg syndrome…”
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PI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes by Larribere, L, Khaled, M, Tartare-Deckert, S, Busca, R, Luciano, F, Bille, K, Valony, G, Eychene, A, Auberger, P, Ortonne, J P, Ballotti, R, Bertolotto, C

“…Melanocytes are cells of the epidermis that synthesize melanin, which is responsible for skin pigmentation. Transformation of melanocytes leads to melanoma, a…”
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39 The Search for Rare Variants That Contribute to Cancer Susceptibility by Lesueur, F, Bertolotto, C, Park, D.J, Demenais, F, Ballotti, R, Bressac-de Paillerets, B, Southey, M.C, Goldgar, D.E, Tavtitgian, S.V

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Involvement of FKHRL1 in melanoma cell survival and death by Hilmi, C., Larribere, L., Deckert, M., Rocchi, S., Giuliano, S., Bille, K., Ortonne, J.P., Ballotti, R., Bertolotto, C.

“…Summary Melanoma is a highly aggressive tumour characterized by a strong resistance to apoptotic stimuli that give rise to a selective advantage for tumour…”
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Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny by Cheli, Y, Giuliano, S, Botton, T, Rocchi, S, Hofman, V, Hofman, P, Bahadoran, P, Bertolotto, C, Ballotti, R

“…In melanoma, as well as in other solid tumors, the cells within a given tumor exhibit strong morphological, functional and molecular heterogeneity that might…”
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Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth by Botton, T, Puissant, A, Cheli, Y, Tomic, T, Giuliano, S, Fajas, L, Deckert, M, Ortonne, J-P, Bertolotto, C, Tartare-Deckert, S, Ballotti, R, Rocchi, S

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Meeting report from the Society for Melanoma Research 2012 Congress, Hollywood, California by Lo, R. S., Ribas, A., Long, G. V., Ballotti, R., Berger, M., Willy, H., Gibney, G. T., Bosenberg, M., Bernstein, E., Villanueva, J., Smalley, K. S. M.

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Regulation of Tyrosinase Gene Expression by cAMP in B16 Melanoma Cells Involves Two CATGTG Motifs Surrounding the TATA Box: Implication of the Microphthalmia Gene Product by Bertolotto, Corine, Bille, Karine, Ortonne, Jean-Paul, Ballotti, Robert

“…In melanocytes and in melanoma cells, upregulation of melanogenesis, by cAMP elevating agents, results from a stimulation of tyrosinase activity that has been…”
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The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro by GIORGETTI, S, BALLOTTI, R, KOWALSKI-CHAUVEL, A, TARTARE, S, VAN OBBERGHEN, E

“…Phosphatidylinositol 3-kinase (PtdIns-3-kinase) is thought to participate in the transductional cascade used by several tyrosine kinase receptors including the…”
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Metformin blocks melanoma invasion and metastasis development in AMPK/p53-dependent manner by Cerezo, Michaël, Tichet, Mélanie, Abbe, Patricia, Ohanna, Mickaël, Lehraiki, Abdelali, Rouaud, Florian, Allegra, Maryline, Giacchero, Damien, Bahadoran, Philippe, Bertolotto, Corine, Tartare-Deckert, Sophie, Ballotti, Robert, Rocchi, Stéphane

“…Metformin was reported to inhibit the proliferation of many cancer cells, including melanoma cells. In this report, we investigated the effect of metformin on…”
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