Search Results - "Ballet, François"

FXR: Big fish or small fry for drug-induced liver injury? by Ballet, François

“…Summary By integrating network analysis and molecular modeling, a “system pharmacology” approach identified FXR as a potential off-target protein mediating…”
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Preventing Drug-Induced Liver Injury: How Useful Are Animal Models? by Ballet, François

“…Drug-induced liver injury (DILI) is the most common organ toxicity encountered in regulatory animal toxicology studies required prior to the clinical…”
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Vectorial Production of Interleukin 1 and Interleukin 6 by Rat Sertoli Cells Cultured in a Dual Culture Compartment System by Cudicini, Corinne, Kercret, Henri, Touzalin, Anne-Marie, Ballet, François, Jégou, Bernard

“…Abstract The bidirectional production of interleukin-1 (IL-1) and IL-6 by Sertoli cells and its regulation by inflammatory and physiological stimuli has been…”
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Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture by Hillaire, S, Ballet, F, Franco, D, Setchell, K D, Poupon, R

“…Hepatic bile acid concentrations are elevated in chronic cholestasis because of reduced canalicular excretion and active ileal absorption of the fraction…”
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Creatine kinase-BB: a marker of liver sinusoidal damage in ischemia-reperfusion by Vaubourdolle, M, Chazouilleres, O, Poupon, R, Ballet, F, Braunwald, J, Legendre, C, Baudin, B, Kirn, A, Giboudeau, J

“…Cell damage within the sinusoidal lining of human liver grafts during transplantation is an early event that is critical in ischemia-reperfusion injury and…”
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Hepatotoxicity in drug development: detection, significance and solutions by Ballet, François

“…Despite considerable progress in the understanding of the mechanism of liver toxicity we are not yet able to design non-hepatotoxic molecules rationally. Also,…”
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Actin filament alteration as a potential marker for cholestasis: a study in isolated rat hepatocyte couplets by Thibault, N, Claude, J R, Ballet, F

“…It has been suggested that modification of the pericanalicular microfilament network (F-actin) plays a role in cholestasis. The purposes of this study were to…”
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Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies by Loeper, J, Descatoire, V, Maurice, M, Beaune, P, Belghiti, J, Houssin, D, Ballet, F, Feldmann, G, Guengerich, F P, Pessayre, D

“…Anti-cytochrome P-450 autoantibodies are present in several forms of autoimmune hepatitis. The possibility that cytochromes P-450 are present in the plasma…”
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Hepatic circulation: potential for therapeutic intervention by Ballet, F

“…In recent years, knowledge of the physiology and pharmacology of hepatic circulation has grown rapidly. Liver microcirculation has a unique design that allows…”
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Phase I and Phase II drug‐metabolizing enzymes are expressed and heterogeneously distributed in the biliary epithelium by Lakehal, Fatima, Wendum, Dominique, Barbu, Véronique, Becquemont, Laurent, Poupon, Raoul, Balladur, Pierre, Hannoun, Laurent, Ballet, François, Beaune, Philippe H., Housset, Chantal

“…Tissue expression of drug‐metabolizing enzymes influences susceptibility to drugs and carcinogens. Because the biliary epithelium, exposed to bile‐borne…”
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How to improve clinical research performances in France? by Diebolt, Vincent, Pletan, Yannick

“…The general objective of this study was to proceed an inventory of measures which could help to improve the efficiency of clinical research in France. Thanks…”
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Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera by Robin, M A, Maratrat, M, Le Roy, M, Le Breton, F P, Bonierbale, E, Dansette, P, Ballet, F, Mansuy, D, Pessayre, D

“…Patients with tienilic acid hepatitis exhibit autoantibodies that recognize unalkylated cytochrome P450 2C9 in humans but recognize 2C11 in rats. Our aim was…”
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Regulation of the Major Detoxication Functions by Phenobarbital and 3‐Methylcholanthrene in Co‐Cultures of Rat Hepatocytes and Liver Epithelial Cells by Lerche, Carole, Fautrel, Alain, Shaw, Peter M., Glaise, Denise, Ballet, Francois, Guillouzo, Andre, Corcos, Laurent

“…In the present study, we analysed the expression of monooxygenase activities and mRNAs associated with cytochrome P‐450 (CYP), including CYP1A1/2, CYP2B1/2,…”
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Preservation-induced liver injury. Clinical aspects, mechanisms and therapeutic approaches by Chazouillères, O, Calmus, Y, Vaubourdolle, M, Ballet, F

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Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes by Hillaire, S, Boucher, E, Calmus, Y, Gane, P, Ballet, F, Franco, D, Moukthar, M, Poupon, R

“…Major histocompatibility complex (MHC) class I molecules, which are normally poorly expressed on the surface of hepatocytes, are overexpressed during…”
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Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets by Thibault, N, Ballet, F

“…The effects of bile acids on cytosolic free calcium ([Ca2+]i) were studied in single isolated rat hepatocyte couplets using a scanning laser cytometer and the…”
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Intrasplenic hepatocellular transplantation corrects hepatic encephalopathy in portacaval-shunted rats by Ribeiro, J, Nordlinger, B, Ballet, F, Cynober, L, Coudray-Lucas, C, Baudrimont, M, Legendre, C, Delelo, R, Panis, Y

“…The aim of this work was to evaluate the effect of intrasplenic hepatocellular transplantation on hepatic encephalopathy in an experimental model of chronic…”
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Isolation, culture and characterization of adult human hepatocytes from surgical liver biopsies by Ballet, F, Bouma, M E, Wang, S R, Amit, N, Marais, J, Infante, R

“…A technique is described for isolation and culture of adult human hepatocytes from surgical liver biopsies. The mean cell yield was 1.75 X 10(7) cells per gm…”
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Vectorial Production of Interleukin 1 and Interleukin 6 by Rat Sertoli Cells Cultured in a Dual Culture Compartment System1 by Cudicini, Corinne, Kercret, Henri, Touzalin, Anne-Marie, Ballet, François, Jégou, Bernard

“…The bidirectional production of interleukin-1 (IL-1) and IL-6 by Sertoli cells and its regulation by inflammatory and physiological stimuli has been studied…”
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Human Leydig Cells and Sertoli Cells Are Producers of Interleukins-1 and -61 by Cudicini, Corinne, Lejeune, Hervé, Gomez, Edith, Bosmans, Eugène, Ballet, François, Saez, José, Jégou, Bernard

“…Interleukins (IL)-1 and -6 have been shown to be produced by several categories of cells in the rat testis and involved in the paracrine control of testicular…”
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