Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients

Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients

Mechanisms involved in thyroid dysfunction in critically ill coronavirus disease 2019 (COVID-19) patients are not clear. Our objective was to correlate the thyroid response with the pro- and anti-inflammatory cytokines profile in critically ill COVID-19 patients. This was a prospective single-center...

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Bibliographic Details
Published in:Biomedicines Vol. 11; no. 1; p. 26
Main Authors: Figueras Castilla, Albert, Ballesteros Vizoso, María A, Iglesias Coma, Amanda, Barceló, Antonia, Barea-Mendoza, Jesús A, Argente Del Castillo, Paula, Guardiola, Begoña, Pérez-Bárcena, Jon, Llompart-Pou, Juan A
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 22-12-2022
MDPI
Subjects:
Coronaviruses
COVID-19
Cytokines
Hormone replacement therapy
Immunoassay
Inflammation
Interleukin 10
Lactic acid
Mortality
organ failure
Regression analysis
Severe acute respiratory syndrome coronavirus 2
Thyroid gland
Thyroid hormones
Thyroid-stimulating hormone
Thyroxine
Triiodothyronine
United States > US
COVID-19
cytokines
organ failure
thyroid hormones
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Summary:Mechanisms involved in thyroid dysfunction in critically ill coronavirus disease 2019 (COVID-19) patients are not clear. Our objective was to correlate the thyroid response with the pro- and anti-inflammatory cytokines profile in critically ill COVID-19 patients. This was a prospective single-center study. We studied the relationship between continuous variables by using Pearson correlation and simple linear regression. Multiple logistic regression analysis was performed to analyze the factors independently associated with mortality. Seventy-eight patients were included in the study at intensive care unit (ICU) admission and 72 had a measurement of the thyroid and inflammatory profile at day 5. No significant correlations were found between thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) and inflammatory cytokines at ICU admission. At day 5, fT4, was inversely correlated with IL-10 (p = 0.035). IL-10 was associated with maximum lactate (p < 0.001) and SOFA score values (p = 0.012). The multiple logistic regression analysis showed that there was a significant relationship between IL-10 (day 5) and in-hospital mortality after adjusting by age and severity of illness. In conclusion, we found that the thyroid hormone profile and inflammatory cytokines had a weak correlation at ICU admission. Associations of interest between fT4 and IL-10 were found at day 5. IL-10 at day 5 was found to be correlated with low fT4 and markers of organ failure and death.
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ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11010026