Cardiovascular magnetic resonance reference values of right ventricular volumetric variables in patients with hypoplastic left heart syndrome

Cardiovascular magnetic resonance (CMR) has established itself as the gold standard for serial assessment of systemic right ventricular (RV) performance but due to the lack of standardized RV reference values for hypoplastic left heart syndrome (HLHS) patients, the interpretation of RV volumetric da...

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Bibliographic Details
Published in:	Journal of cardiovascular magnetic resonance Vol. 26; no. 1; p. 101038
Main Authors:	Ballenberger, Andrik, Caliebe, Amke, Krupickova, Sylvia, Uebing, Anselm, Gabbert, Dominik Daniel, Voges, Inga
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 2024 Elsevier
Subjects:	Adolescent Adult Age Factors Cardiovascular magnetic resonance Child Child, Preschool Children Female Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Hypoplastic left heart syndrome Hypoplastic Left Heart Syndrome - diagnostic imaging Hypoplastic Left Heart Syndrome - physiopathology Hypoplastic Left Heart Syndrome - surgery Magnetic Resonance Imaging, Cine Male Predictive Value of Tests Reference Values Reproducibility of Results Retrospective Studies Stroke Volume Ventricular Function, Right Young Adult RVSV Hypoplastic left heart syndrome RV Cardiovascular magnetic resonance TCPC ICC CMR RVEDMM IQR HLHS Reference values RVESV BSA LMS RVEDV Children
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Summary:	Cardiovascular magnetic resonance (CMR) has established itself as the gold standard for serial assessment of systemic right ventricular (RV) performance but due to the lack of standardized RV reference values for hypoplastic left heart syndrome (HLHS) patients, the interpretation of RV volumetric data in HLHS remains difficult. Therefore, this study aimed to close this gap by providing CMR reference values for the systemic RV in HLHS patients. CMR scans of 160 children, adolescents, and young adults (age range 2.2–25.2 years, 106 males) with HLHS were retrospectively evaluated. All patients were studied following total cavopulmonary connection. Short-axis stacks were used to measure RV end-diastolic and end-systolic volumes (RVEDV, RVESV), RV stroke volume (RVSV), RV ejection fraction (RVEF), and RV end-diastolic myocardial mass (RVEDMM). Univariable and multiple linear regression analyses were performed to assess associations between RV parameters and demographic and anthropometric characteristics. Following the results of the regression analysis, reference graphs and tables were created with the Lambda-Mu-Sigma method. Multiple linear regression analysis showed strong associations between body height and RVEDV, RVESV as well as RVSV. Age was highly associated with RVEDMM. Therefore, percentile curves and tables were created with respect to body height (RVEDV, RVESV, RVSV) and age (RVEDMM). The influence of demographic and anthropometric parameters on RVEF was mild, thus no percentile curves and tables for RVEF are provided. We were able to define CMR reference values for RV volumetric variables for HLHS patients. These data might be useful for the assessment and interpretation of CMR scans in these patients and for research in this field. [Display omitted]
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1097-6647 1532-429X 1532-429X
DOI:	10.1016/j.jocmr.2024.101038