Search Results - "Ballard, T"

Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging by Murrey, Heather E, Judkins, Joshua C, am Ende, Christopher W, Ballard, T. Eric, Fang, Yinzhi, Riccardi, Keith, Di, Li, Guilmette, Edward R, Schwartz, Joel W, Fox, Joseph M, Johnson, Douglas S

“…Bioorthogonal reactions, including the strain-promoted azide–alkyne cycloaddition (SPAAC) and inverse electron demand Diels–Alder (iEDDA) reactions, have…”
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Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks by Orr, Suvi T. M, Ripp, Sharon L, Ballard, T. Eric, Henderson, Jaclyn L, Scott, Dennis O, Obach, R. Scott, Sun, Hao, Kalgutkar, Amit S

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Inhibition of HIV Fusion with Multivalent Gold Nanoparticles by Bowman, Mary-Catherine, Ballard, T. Eric, Ackerson, Christopher J, Feldheim, Daniel L, Margolis, David M, Melander, Christian

“…The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized…”
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Investigation of the absolute bioavailability, mass balance, metabolism, and excretion of the cholesterol 24‐hydroxylase inhibitor soticlestat in healthy volunteers by Yin, Wei, Ballard, T. Eric, Zhu, Sean Xiaochun, Hsiao, Samuel, Chen, Hao, Li, Yuexian, Chowdhury, Swapan K., Stevenson, Annette, Hui, Tom, Hunt, Allen, Asgharnejad, Mahnaz, Han, Steve

“…Aims Our aim was to determine the absolute bioavailability, mass balance, metabolism and excretion of soticlestat (TAK‐935). Methods An open‐label, two‐period,…”
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Synthesis and Antibiofilm Activity of a Second-Generation Reverse-Amide Oroidin Library: A Structure-Activity Relationship Study by Ballard, T. Eric, Richards, Justin J., Wolfe, Amanda L., Melander, Christian

“…A second‐generation library of 2‐aminoimidazole‐based derivatives incorporating a “reversed amide” (RA) motif in comparison to the marine natural product…”
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Simplifying the Execution of HepatoPac MetID Experiments: Metabolite Profile and Intrinsic Clearance Comparisons by Ballard, T. Eric, Kratochwil, N., Cox, Loretta M., Moen, Mark A., Klammers, F., Ekiciler, A., Goetschi, A., Walter, I.

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Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism by Ballard, T Eric, Wang, Shuai, Cox, Loretta M, Moen, Mark A, Krzyzewski, Stacy, Ukairo, Okechukwu, Obach, R Scott

“…Laboratory animal models are the industry standard for preclinical risk assessment of drug candidates. Thus, it is important that these species possess…”
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The Importance of Tracking “Missing” Metabolites: How and Why? by Wang, Shuai, Ballard, T. Eric, Christopher, Lisa J., Foti, Robert S., Gu, Chungang, Khojasteh, S. Cyrus, Liu, Joyce, Ma, Shuguang, Ma, Bin, Obach, R. Scott, Schadt, Simone, Zhang, Zhoupeng, Zhang, Donglu

“…Technologies currently employed to find and identify drug metabolites in complex biological matrices generally yield results that offer a comprehensive picture…”
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Microwave-assisted extraction of betalains from red beet (Beta vulgaris) by Cardoso-Ugarte, G.A., Sosa-Morales, M.E., Ballard, T., Liceaga, A., San Martín-González, M.F.

“…The use of microwave assisted extraction (MAE) was investigated in this work for the extraction of betalains from diced red beets. Several treatments with…”
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Increased growing temperature reduces content of polyunsaturated fatty acids in four oilseed crops by Schulte, L.R., Ballard, T., Samarakoon, T., Yao, L., Vadlani, P., Staggenborg, S., Rezac, M.

“…•Molar amounts of oleic, linoleic and linolenic acid change with temperature.•Linear regressions of literature data correctly predict molar amounts of fatty…”
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An Isotopically Tagged Azobenzene-Based Cleavable Linker for Quantitative Proteomics by Qian, Yu, Martell, Julianne, Pace, Nicholas J., Ballard, T. Eric, Johnson, Douglas S., Weerapana, Eranthie

“…Putting a number on it: Cleavable linkers are widely utilized in proteomics applications. In particular, the azobenzene‐based linker cleaves under mild…”
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Mucociliary transport in porcine trachea: differential effects of inhibiting chloride and bicarbonate secretion by Cooper, Jeffrey L, Quinton, Paul M, Ballard, Stephen T

“…This study was designed to assess the relative importance of Cl(-) and HCO(3)(-) secretion to mucociliary transport rate (MCT) in ex vivo porcine tracheas. MCT…”
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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR by Planken, Simon, Behenna, Douglas C, Nair, Sajiv K, Johnson, Theodore O, Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G, Dinh, Dac M, Edwards, Martin P, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle, Kania, Robert S, Kath, John C, Matthews, Jean, Murray, Brion W, Niessen, Sherry, Orr, Suvi T. M, Pairish, Mason, Sach, Neal W, Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L, Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer

“…Mutant epidermal growth factor receptor (EGFR) is a major driver of non-small-cell lung cancer (NSCLC). Marketed first generation inhibitors, such as…”
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γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin by Pozdnyakov, Nikolay, Murrey, Heather E., Crump, Christina J., Pettersson, Martin, Ballard, T.Eric, am Ende, Christopher W., Ahn, Kwangwook, Li, Yue-Ming, Bales, Kelly R., Johnson, Douglas S.

“…γ-Secretase is an intramembrane aspartyl protease that cleaves the amyloid precursor protein to produce neurotoxic β-amyloid peptides (i.e. Aβ42) that have…”
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Translocation Carcinomas of the Kidney After Chemotherapy in Childhood by ARGANI, Pedram, LAE, Marick, BALLARD, Edgar T, AMIN, Mahul, MANIVEL, Carlos, HUTCHINSON, Brian, REUTER, Victor E, LADANYI, Marc

“…Children who survive cancer are at more than 19-fold increased risk of developing another malignancy. Renal cell carcinoma (RCC) occurring as a secondary…”
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Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues by Richards, Justin J, Ballard, T Eric, Melander, Christian

“…The marine alkaloid oroidin along with a small library of reverse amide (RA) 2-aminoimidazoles were synthesized and assayed for anti-biofilm activity against…”
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Determination of Antibody–Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation by Bessire, Andrew J, Ballard, T. Eric, Charati, Manoj, Cohen, Justin, Green, Michael, Lam, My-Hanh, Loganzo, Frank, Nolting, Birte, Pierce, Betsy, Puthenveetil, Sujiet, Roberts, Lee, Schildknegt, Klaas, Subramanyam, Chakrapani

“…Antibody-drug conjugates (ADC) are currently an active area of research, focused primarily on oncology therapeutics, but also to a limited extent on other…”
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Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans by Ryder, Tim F., Bergman, Arthur, King-Ahmad, Amanda, Amin, Neeta B., Lall, Manjinder S., Ballard, T. Eric, Kalgutkar, Amit S.

“…The disposition of the hepatoselective ACC inhibitor PF-05221304 (Clesacostat) was studied after a single 50-mg oral dose of [14C]-PF-05221304 to healthy human…”
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Impacts of forest management on northern forest soils by Ballard, T.M.

“…Many effects of forest management on northern soil environments are characteristic of other latitudes, as well. Nutrient removals in harvested timber are…”
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Anticancer effects of lipid encapsulated Bilberry by Thornthwaite, J, Thibado, S, Ballard, T, Goodman, B

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