Analysis of anti-protective antigen IgG subclass distribution in recipients of anthrax vaccine adsorbed (AVA) and patients with cutaneous and inhalation anthrax

Abstract The anti-PA IgG1, IgG2, IgG3, and IgG4 subclass responses to clinical anthrax and to different numbers of anthrax vaccine adsorbed (AVA, BioThrax® ) injections were determined in a cross-sectional study of sera from 63 vaccinees and 13 clinical anthrax patients. The data show that both vacc...

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Bibliographic Details
Published in:	Vaccine Vol. 25; no. 10; pp. 1780 - 1788
Main Authors:	Semenova, V.A, Schmidt, D.S, Taylor, T.H, Li, H, Steward-Clark, E, Soroka, S.D, Ballard, M.M, Quinn, C.P
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 26-02-2007 Elsevier Elsevier Limited
Subjects:	Adult Aged Allergy and Immunology Anthrax Anthrax - immunology Anthrax Vaccines - immunology Anti-PA antibody Antibodies, Bacterial - blood Antibodies, Bacterial - classification Antigens Antigens, Bacterial - immunology Antitoxins - blood Applied microbiology AVA Bacillus anthracis Bacterial Toxins - immunology Biological & chemical terrorism Biological and medical sciences BioThrax Blood banks Dilution Enzymes Female Fundamental and applied biological sciences. Psychology Humans IgG subclasses Immune system Immunoglobulin G - blood Immunoglobulin G - classification Infections Inhalation Injections Male Microbiology Middle Aged Neutralization Toxins Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Bacillus anthracis Anti-PA antibody BioThrax AVA Anthrax IgG subclasses Human Antibody IgG Recipient Vaccine Bacillaceae Inhalation Infection Antigen Bacillales Bacteriosis Bacteria
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Summary:	Abstract The anti-PA IgG1, IgG2, IgG3, and IgG4 subclass responses to clinical anthrax and to different numbers of anthrax vaccine adsorbed (AVA, BioThrax® ) injections were determined in a cross-sectional study of sera from 63 vaccinees and 13 clinical anthrax patients. The data show that both vaccination with three AVA injections and clinical anthrax elicit anti-PA IgG1, IgG2, and IgG3 subclass responses. An anti-PA IgG4 response was detected in AVA recipients after the fourth injection. The anthrax lethal toxin (LTx) neutralization efficacy of sera from recipients who received 4 to ≥10 AVA injections did not vary significantly in relation to changes in distribution of anti-PA IgG1 and IgG4 subclasses.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2006.11.028