Search Results - "Ball, Claudia R."

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking by Weischenfeldt, Joachim, Dubash, Taronish, Drainas, Alexandros P, Mardin, Balca R, Chen, Yuanyuan, Stütz, Adrian M, Waszak, Sebastian M, Bosco, Graziella, Halvorsen, Ann Rita, Raeder, Benjamin, Efthymiopoulos, Theocharis, Erkek, Serap, Siegl, Christine, Brenner, Hermann, Brustugun, Odd Terje, Dieter, Sebastian M, Northcott, Paul A, Petersen, Iver, Pfister, Stefan M, Schneider, Martin, Solberg, Steinar K, Thunissen, Erik, Weichert, Wilko, Zichner, Thomas, Thomas, Roman, Peifer, Martin, Helland, Aslaug, Ball, Claudia R, Jechlinger, Martin, Sotillo, Rocio, Glimm, Hanno, Korbel, Jan O

“…Hanno Glimm, Jan Korbel and colleagues present a computational framework called cis expression structural alteration mapping (CESAM), which they use to…”
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Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases by Dieter, Sebastian M., Ball, Claudia R., Hoffmann, Christopher M., Nowrouzi, Ali, Herbst, Friederike, Zavidij, Oksana, Abel, Ulrich, Arens, Anne, Weichert, Wilko, Brand, Karsten, Koch, Moritz, Weitz, Jürgen, Schmidt, Manfred, von Kalle, Christof, Glimm, Hanno

“…Human colon cancer harbors a small subfraction of tumor-initiating cells (TICs) that is assumed to be a functionally homogeneous stem-cell-like population…”
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Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells by Voloshanenko, Oksana, Erdmann, Gerrit, Dubash, Taronish D., Augustin, Iris, Metzig, Marie, Moffa, Giusi, Hundsrucker, Christian, Kerr, Grainne, Sandmann, Thomas, Anchang, Benedikt, Demir, Kubilay, Boehm, Christina, Leible, Svenja, Ball, Claudia R., Glimm, Hanno, Spang, Rainer, Boutros, Michael

“…Aberrant regulation of the Wnt/β-catenin pathway has an important role during the onset and progression of colorectal cancer, with over 90% of cases of…”
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YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis by Thomann, Stefan, Weiler, Sofia M E, Marquard, Simone, Rose, Fabian, Ball, Claudia R, Tóth, Marcell, Wei, Teng, Sticht, Carsten, Fritzsche, Sarah, Roessler, Stephanie, De La Torre, Carolina, Ryschich, Eduard, Ermakova, Olga, Mogler, Carolin, Kazdal, Daniel, Gretz, Norbert, Glimm, Hanno, Rempel, Eugen, Schirmacher, Peter, Breuhahn, Kai

“…The oncogene yes-associated protein (YAP) controls liver tumor initiation and progression via cell extrinsic functions by creating a tumor-supporting…”
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Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis by Bormann, Felix, Rodríguez-Paredes, Manuel, Lasitschka, Felix, Edelmann, Dominic, Musch, Tanja, Benner, Axel, Bergman, Yehudit, Dieter, Sebastian M., Ball, Claudia R., Glimm, Hanno, Linhart, Heinz G., Lyko, Frank

“…Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation…”
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The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo by Weber, Sarah, Koschade, Sebastian E, Hoffmann, Christopher M, Dubash, Taronish D, Giessler, Klara M, Dieter, Sebastian M, Herbst, Friederike, Glimm, Hanno, Ball, Claudia R

“…While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still…”
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Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold by Schmäche, Tim, Fohgrub, Juliane, Klimova, Anna, Laaber, Karin, Drukewitz, Stephan, Merboth, Felix, Hennig, Alexander, Seidlitz, Therese, Herbst, Friederike, Baenke, Franziska, Ada, Anne-Marlen, Groß, Thomas, Wenzel, Carina, Ball, Claudia R, Praetorius, Christian, Schmidt, Thomas, Ringelband-Schilling, Barbara, Koschny, Ronald, Stenzinger, Albrecht, Roeder, Ingo, Jaeger, Dirk, Zeissig, Sebastian, Welsch, Thilo, Aust, Daniela, Glimm, Hanno, Folprecht, Gunnar, Weitz, Jürgen, Haag, Georg M, Stange, Daniel E

“…This study sought to determine the value of patient-derived organoids (PDOs) from esophago-gastric adenocarcinoma (EGC) for response prediction to neoadjuvant…”
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Virotherapy combined with anti-PD-1 transiently reshapes the tumor immune environment and induces anti-tumor immunity in a preclinical PDAC model by Veinalde, Rūta, Pidelaserra-Martí, Gemma, Moulin, Coline, Tan, Chin Leng, Schäfer, Theresa E, Kang, Na, Ball, Claudia R, Leichsenring, Jonas, Stenzinger, Albrecht, Kaderali, Lars, Jäger, Dirk, Ungerechts, Guy, Engeland, Christine E

“…Pancreatic ductal adenocarcinoma (PDAC) is largely refractory to cancer immunotherapy with PD-1 immune checkpoint blockade (ICB). Oncolytic virotherapy has…”
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A vector-encoded bispecific killer engager to harness virus-activated NK cells as anti-tumor effectors by Floerchinger, Alessia, Klein, Jessica E., Finkbeiner, Maximiliane S. C., Schäfer, Theresa E., Fuchs, Gwendolin, Doerner, Johannes, Zirngibl, Hubert, Ackermann, Maximilian, Kvasnicka, Hans M., Chester, Kerry A., Jäger, Dirk, Ball, Claudia R., Ungerechts, Guy, Engeland, Christine E.

“…Treatment with oncolytic measles vaccines (MV) elicits activation of immune cells, including natural killer (NK) cells. However, we found that MV-activated NK…”
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Extensive Methylation of Promoter Sequences Silences Lentiviral Transgene Expression During Stem Cell Differentiation In Vivo by Herbst, Friederike, Ball, Claudia R, Tuorto, Francesca, Nowrouzi, Ali, Wang, Wei, Zavidij, Oksana, Dieter, Sebastian M, Fessler, Sylvia, van der Hoeven, Franciscus, Kloz, Ulrich, Lyko, Frank, Schmidt, Manfred, von Kalle, Christof, Glimm, Hanno

“…Lentiviral vectors (LV) are widely used to stably transfer genes into target cells investigating or treating gene functions. In addition, gene transfer into…”
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Comprehensive genomic access to vector integration in clinical gene therapy by Arens, Anne, Naldini, Luigi, Cattoglio, Claudia, Eckenberg, Ralph, Deichmann, Annette, Bartholomae, Cynthia C, Faber, Katrin, Nowrouzi, Ali, Paruzynski, Anna, Montini, Eugenio, Thrasher, Adrian J, Ali, Robin R, Saurin, William, Kirsten, Romy, Schwarzwaelder, Kerstin, Schmidt, Manfred, Balaggan, Kamaljit S, Glimm, Hanno, Gaspar, H Bobby, Cesana, Daniela, Biasco, Luca, Aiuti, Alessandro, Howe, Steven J, Recchia, Alessandra, Gabriel, Richard, Cohen-Haguenauer, Odile, Wang, Wei, Mavilio, Fulvio, Yáñez-Muñoz, Rafael J, von Kalle, Christof, Ball, Claudia R

“…Retroviral vectors have induced subtle clonal skewing in many gene therapy patients and severe clonal proliferation and leukemia in some of them, emphasizing…”
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Colorectal cancer‐initiating cells caught in the act by Dieter, Sebastian M, Glimm, Hanno, Ball, Claudia R

“…Our increased awareness of the clonal organization of many hematological and solid cancers has dramatically changed our view on the design of novel therapeutic…”
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Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts by Ball, Claudia R, Oppel, Felix, Ehrenberg, Karl Roland, Dubash, Taronish D, Dieter, Sebastian M, Hoffmann, Christopher M, Abel, Ulrich, Herbst, Friederike, Koch, Moritz, Werner, Jens, Bergmann, Frank, Ishaque, Naveed, Schmidt, Manfred, von Kalle, Christof, Scholl, Claudia, Fröhling, Stefan, Brors, Benedikt, Weichert, Wilko, Weitz, Jürgen, Glimm, Hanno

“…Although tumor‐initiating cell (TIC) self‐renewal has been postulated to be essential in progression and metastasis formation of human pancreatic…”
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Transforming growth factor beta receptor 2 (TGFBR2) changes sialylation in the microsatellite unstable (MSI) Colorectal cancer cell line HCT116 by Lee, Jennifer, Ballikaya, Seda, Schönig, Kai, Ball, Claudia R, Glimm, Hanno, Kopitz, Juergen, Gebert, Johannes

“…Aberrant glycosylation is a common feature of many malignancies including colorectal cancers (CRCs). About 15% of CRC show the microsatellite instability (MSI)…”
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Let's get functional: Drug sensitivity profiling to enable precision sarcoma medicine by Ball, Claudia R, Fröhling, Stefan

“…Drug sensitivity profiling in patient-derived tumor models offers new hope for improving outcomes in cancers lacking effective therapies. Al Shihabi et al…”
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You Can Count on This: Barcoded Hematopoietic Stem Cells by Glimm, Hanno, Ball, Claudia R., von Kalle, Christof

“…Understanding how individual hematopoietic stem cells contribute to blood formation requires analysis at the single-cell level. Recently in Nature…”
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Systematic Generation of Patient-Derived Tumor Models in Pancreatic Cancer by Ehrenberg, Karl Roland, Gao, Jianpeng, Oppel, Felix, Frank, Stephanie, Kang, Na, Dieter, Sebastian M, Herbst, Friederike, Möhrmann, Lino, Dubash, Taronish D, Schulz, Erik R, Strakerjahn, Hendrik, Giessler, Klara M, Weber, Sarah, Oberlack, Ava, Rief, Eva-Maria, Strobel, Oliver, Bergmann, Frank, Lasitschka, Felix, Weitz, Jürgen, Glimm, Hanno, Ball, Claudia R

“…In highly aggressive malignancies like pancreatic cancer (PC), patient-derived tumor models can serve as disease-relevant models to understand disease-related…”
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Targeted BiTE Expression by an Oncolytic Vector Augments Therapeutic Efficacy Against Solid Tumors by Speck, Tobias, Heidbuechel, Johannes P W, Veinalde, Rūta, Jaeger, Dirk, von Kalle, Christof, Ball, Claudia R, Ungerechts, Guy, Engeland, Christine E

“…Immunotherapy with bispecific T-cell engagers has achieved striking success against hematologic malignancies, but efficacy against solid tumors has been…”
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Stem-Cell Gene Therapy for the Wiskott–Aldrich Syndrome by Boztug, Kaan, Schmidt, Manfred, Schwarzer, Adrian, Banerjee, Pinaki P, Díez, Inés Avedillo, Dewey, Ricardo A, Böhm, Marie, Nowrouzi, Ali, Ball, Claudia R, Glimm, Hanno, Naundorf, Sonja, Kühlcke, Klaus, Blasczyk, Rainer, Kondratenko, Irina, Maródi, László, Orange, Jordan S, von Kalle, Christof, Klein, Christoph

“…The authors report the long-term (up to 3 years) correction of the Wiskott–Aldrich syndrome in two patients through retroviral infection of CD34+ hematopoietic…”
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Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer by Dieter, Sebastian M., Siegl, Christine, Codó, Paula L., Huerta, Mario, Ostermann-Parucha, Anna L., Schulz, Erik, Zowada, Martina K., Martin, Sylvia, Laaber, Karin, Nowrouzi, Ali, Blatter, Mona, Kreth, Sina, Westermann, Frank, Benner, Axel, Uhrig, Ulrike, Putzker, Kerstin, Lewis, Joe, Haegebarth, Andrea, Mumberg, Dominik, Holton, Simon J., Weiske, Joerg, Toepper, Lena-Marit, Scheib, Ulrike, Siemeister, Gerhard, Ball, Claudia R., Kuster, Bernhard, Stoehr, Gabriele, Hahne, Hannes, Johannes, Sarah, Lange, Martin, Herbst, Friederike, Glimm, Hanno

“…Novel treatment options for metastatic colorectal cancer (CRC) are urgently needed to improve patient outcome. Here, we screen a library of non-characterized…”
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