Search Results - "Ball, Alicja M."

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery by Harikumar, Kaleeckal G, Wootten, Denise, Pinon, Delia I, Koole, Cassandra, Ball, Alicja M, Furness, Sebastian G. B, Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J, Sexton, Patrick M

“…The glucagon-like peptide-1 receptor (GLP-1R) is a family B G protein-coupled receptor and an important drug target for the treatment of type II diabetes, with…”
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Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping by Dong, Maoqing, Xu, Xiequn, Ball, Alicja M., Makhoul, Joshua A., Lam, Polo C.‐H., Pinon, Delia I., Orry, Andrew, Sexton, Patrick M., Abagyan, Ruben, Miller, Laurence J.

“…While it is evident that the carboxyl‐terminal region of natural peptide ligands bind to the amino‐terminal domain of class B GPCRs, how their biologically…”
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Molecular Basis for Binding and Subtype Selectivity of 1,4-Benzodiazepine Antagonist Ligands of the Cholecystokinin Receptor by Cawston, Erin E., Lam, Polo C.H., Harikumar, Kaleeckal G., Dong, Maoqing, Ball, Alicja M., Augustine, Mary Lou, Akgün, Eyup, Portoghese, Philip S., Orry, Andrew, Abagyan, Ruben, Sexton, Patrick M., Miller, Laurence J.

“…Allosteric binding pockets in peptide-binding G protein-coupled receptors create opportunities for the development of small molecule drugs with substantial…”
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Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization by Harikumar, Kaleeckal G., Ball, Alicja M., Sexton, Patrick M., Miller, Laurence J.

“…Dimerization of the prototypic family B G protein-coupled secretin receptor is determined by the lipid-exposed face of transmembrane segment four (TM4), and…”
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