Search Results - "Balinska, Malgorzata"

Human Cytosolic and Mitochondrial Folylpolyglutamate Synthetase Are Electrophoretically Distinct by McGuire, John J., Russell, Cynthia A., Balinska, Malgorzata

“…Folylpolyglutamate synthetase (FPGS) activity in CCRF-CEM human leukemia cells was found in the cytosolic (≈67% of total) and mitochondrial (≈22%) fractions. A…”
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Identification of new regulatory genes controlling synthesis of folate-dependent enzymes in Aspergillus nidulans by Lewandowska, I, Balinska, M, Paszewski, A

“…Prototrophic revertants of a metH2 strain of Aspergillus nidulans which is impaired in the regulation of synthesis of folate-dependent enzymes were isolated…”
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Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro by Balińska, M, Galivan, J, Coward, J K

“…The efflux of methotrexate and methotrexate polyglutamates was examined with primary monolayer cultures of rat hepatocytes and also with monolayer cultures of…”
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Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines by McGuire, J J, Russell, C A, Balinska, M

“…Folylpolyglutamate synthetase (FPGS) activity in CCRF-CEM human leukemia cells was found in the cytosolic ( approximately 67% of total) and mitochondrial (…”
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Regulation of Folate Metabolizing Enzymes In Fungus Aspergillus nidulans by Balińska Malgorzata, Natorff Renata, Paszewski Andrzej

“…The regulation of methionine synthase. serine hydroxymethyltransferase. methylenetetrahydrofolate oxidorelluctase and dihydrofolate reductase in Aspergillus…”
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Effect of combined inhibitors of thymidylate synthase-5-fluorodeoxyuridine and quinazoline antifolates on murine leukemia cells cultured in vitro by Balinska, M, Szablewska, I, Janiszewska, D, Brzezinska, A, Pawelczak, K

“…The synergistic effect of two different inhibitors of thymidylate synthase-FdUrd and sulphonamide derivatives on murine leukemia cells-5178Y (parental subline)…”
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2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity by Bretner, Maria, Kulikowski, Tadeusz, Dzik, Jolanta M, Balinska, Malgorzata, Rode, Wojciech, Shugar, David

“…A convenient synthesis of 5-fluoro-2-thiouracil (11) is based on hydrolytic deamination of 5-fluoro-2-thiocytosine (9). Lewis acid-catalyzed condensation of…”
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Characteristics of methotrexate polyglutamate formation in cultured hepatic cells by Balinska, M, Nimec, Z, Galivan, J

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Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells by Rhee, M S, Balinska, M, Bunni, M, Priest, D G, Maley, G F, Maley, F, Galivan, J

“…The effects of the lipid-soluble dihydrofolate reductase inhibitor, trimetrexate, on the inhibition of thymidylate biosynthesis as a result of perturbation in…”
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Regulation of methotrexate polyglutamate accumulation in vitro: effects of cellular folate content by Galivan, J, Nimec, Z, Balinska, M

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Inhibition of mammalian thymidylate synthase by 10-formyltetrahydropteroylpolyglutamate by Balinska, M, Rhee, M, Whiteley, J M, Priest, D G, Galivan, J

“…Reduced derivatives of 10-formylfolate have been evaluated as inhibitors of mammalian thymidylate synthase (EC 2.1.1.45) from H35 hepatoma cells. With…”
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Dihydrofolate-mediated reversal of methotrexate toxicity to hepatoma cells in vitro by Kruger-McDermott, C, Balinska, M, Galivan, J

“…H35 hepatoma cells can be rescued from exposure to an inhibitory pulse of methotrexate (MTX) by subsequent addition of folinic acid, dihydrofolate or…”
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Reversibly permeable hepatoma cells in culture by Balinska, M, Samsonoff, W A, Galivan, J

“…A brief treatment of H35 hepatoma cells with lysolecithin resulted in a cell population which is permeable to low-molecular weight charged molecules that…”
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Studies of formation and efflux of methotrexate polyglutamates with cultured hepatic cells by Galivan, J, Balinska, M

“…Methotrexate polyglutamates are extensively synthesized when cultured hepatocytes and H35 hepatoma cells are exposed to micromolar concentrations of…”
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Interrelated regulation of sulphur-containing amino-acid biosynthetic enzymes and folate-metabolizing enzymes in Aspergillus nidulans by Nadolska-Lutyk, J, Balinska, M, Paszewski, A

“…In Aspergillus nidulans homocysteine can be metabolized both to cysteine and methionine. Mutants impaired in the main pathway of cysteine synthesis or in the…”
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Quinazoline Antifolate Thymidylate Synthase Inhibitors: Replacement of Glutamic Acid by Aminophosphonic Acids by Makowski, Maciej, Pawełczak, Krzysztof, Kafarski, Paweł, Dzik, Jolanta M., Gołos, Barbara, Balinska, Małgorzata, Rode, Wojciech

“…The synthesis of six analogues of the potent thymidylate synthase (TS) inhibitor N -[4-[ N -[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinoyl)-methyl]- N…”
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Factors controlling the concentrations of methotrexate in cultured hepatic cells by Galivan, J, Balinska, M, Nimec, Z, Fox, M P

“…The polyglutamate metabolites of methotrexate are as inhibitory to the target enzyme dihydrofolate reductase as is methotrexate. Because of their greater…”
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Cellular aspects of folate and antifolate membrane transport by Brzezińska, A, Wińska, P, Balińska, M

“…Folates--one carbon carriers--take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several…”
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Metabolism of folate glutamates in Aspergillus nidulans by Lewandowska, I, Sikora, E, Szablewska, I, Balińska, M, Paszewski, A

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Interaction of methotrexate poly(L-lysine) with transformed hepatic cells in culture by Galivan, J, Balińska, M, Whiteley, J M

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