Search Results - "Balimane, Praveen V."

Characterization of efflux transporters involved in distribution and disposition of apixaban by Zhang, Donglu, He, Kan, Herbst, John J, Kolb, Janet, Shou, Wilson, Wang, Lifei, Balimane, Praveen V, Han, Yong-Hae, Gan, Jinping, Frost, Charles E, Humphreys, W Griffith

“…The studies reported here were conducted to investigate the transport characteristics of apixaban…”
Get full text

Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds by Marino, Anthony M., Yarde, Melissa, Patel, Hetal, Chong, Saeho, Balimane, Praveen V.

“…The use of Caco-2 cells for permeability screening of discovery compounds is quite well established and serves as the “method-of-choice” across the…”
Get full text

Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery by Balimane, Praveen V, Patel, Karishma, Marino, Anthony, Chong, Saeho

“…The use of Caco-2 cells for screening of discovery compounds for their permeability characteristics and P-glycoprotein interactions is well established and…”
Get full text

Development of a quantitative LC–MS/MS analytical method coupled with turbulent flow chromatography for digoxin for the in vitro P-gp inhibition assay by Smalley, James, Marino, Anthony M., Xin, Baomin, Olah, Timothy, Balimane, Praveen V.

“…Caco-2 cells, the human colon carcinoma cells, are typically used for screening compounds for their permeability characteristics and P-glycoprotein (P-gp)…”
Get full text

Validation of In Vitro Cell-Based Human Blood−Brain Barrier Model Using Clinical Positron Emission Tomography Radioligands To Predict In Vivo Human Brain Penetration by Mabondzo, Aloïse, Bottlaender, Michel, Guyot, Anne-Cécile, Tsaouin, Katya, Deverre, Jean Robert, Balimane, Praveen V

“…We have evaluated a novel in vitro cell-based human blood−brain barrier (BBB) model that could predict in vivo human brain penetration for compounds with…”
Get full text

A Novel Design of Artificial Membrane for Improving the PAMPA Model by Chen, Xiaoxi, Murawski, Anthony, Patel, Karishma, Crespi, Charles L., Balimane, Praveen V.

“…Purpose Since the first demonstration of PAMPA, the artificial membrane has been traditionally prepared by impregnating a porous filter with a solution of…”
Get full text

Application of in vitro CYP and transporter assays to predict clinical drug-drug interactions by Volpe, Donna A, Balimane, Praveen V

Get full text

Current industrial practices of assessing permeability and P-glycoprotein interaction by Balimane, Praveen V, Han, Yong-Hae, Chong, Saeho

“…Combination of the in vitro models that are high throughput but less predictive and the in vivo models that are low throughput but more predictive is used…”
Get full text

Cell culture-based models for intestinal permeability: A critique by Balimane, Praveen V., Chong, Saeho

“…This review article presents a thorough, balanced and unbiased view of the cell culture-based models for permeability assessment in discovery laboratories and…”
Get full text

P-gp Inhibition Potential in Cell-Based Models: Which “Calculation” Method is the Most Accurate? by Balimane, Praveen V., Marino, Anthony, Chong, Saeho

“…The objective was to directly compare the four different “calculation” methods of assessing P-gp inhibition potential using experimental data obtained from ~60…”
Get full text

Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells by Balimane, Praveen V, Chong, Saeho, Patel, Karishma, Quan, Yong, Timoszyk, Julita, Han, Yong-Hae, Wang, Bonnie, Vig, Balvinder, Faria, Teresa N

“…The purpose of this study was to investigate the utility of stably transfected MDCK-hPepT1 cells for identifying peptide transporter substrates in early drug…”
Get full text

Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design by Xiao, Hai-Yun, Watterson, Scott H, Langevine, Charles M, Srivastava, Anurag S, Ko, Soo S, Zhang, Yanlei, Cherney, Robert J, Guo, Wei-Wei, Gilmore, John L, Sheppeck, James E, Wu, Dauh-Rurng, Li, Peng, Ramasamy, Duraisamy, Arunachalam, Piramanayagam, Mathur, Arvind, Taylor, Tracy L, Shuster, David J, McIntyre, Kim W, Shen, Ding-Ren, Yarde, Melissa, Cvijic, Mary Ellen, Marino, Anthony M, Balimane, Praveen V, Yang, Zheng, Banas, Dana M, Cornelius, Georgia, D’Arienzo, Celia J, Warrack, Bethanne M, Lehman-McKeeman, Lois, Salter-Cid, Luisa M, Xie, Jenny, Barrish, Joel C, Carter, Percy H, Dyckman, Alaric J, Dhar, T. G. Murali

“…Fingolimod (1) is the first approved oral therapy for the treatment of relapsing remitting multiple sclerosis. While the phosphorylated metabolite of…”
Get full text

A combined cell based approach to identify P-glycoprotein substrates and inhibitors in a single assay by Balimane, Praveen V., Chong, Saeho

“…The objective of this project was to develop a cell based in vitro experimental procedure that can differentiate P-glycoprotein (P-gp) substrates from…”
Get full text

Development of an in silico model for predicting efflux substrates in Caco-2 cells by Zhang, Litai, Balimane, Praveen V., Johnson, Stephen R., Chong, Saeho

“…P-glycoprotein (P-gp) is an ATP dependent efflux transporter protein that has been demonstrated to play a critical role in affecting the absorption,…”
Get full text

Peptide Transporter Substrate Identification during Permeability Screening in Drug Discovery: Comparison of Transfected MDCK-hPepT1 Cells to Caco-2 Cells by Chong, Sae-Ho, Patel, Karishma, Quan, Yong, Timoszyk, Julita, Han, Yong-Hae, Wang, Bonnie, Vig, Balvinder, Faria, Teresa N, Balimane, Praveen. V

“…The purpose of this study was to investigate the utility of stably transfected MDCK-hPepT1 cells for identifying peptide transporter substrates in early drug…”
Get full text

A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis by Balimane, Praveen V., Pace, Ellen, Chong, Saeho, Zhu, Mingshe, Jemal, Mohammed, Pelt, Colleen K. Van

“…Parallel artificial membrane permeability assay (PAMPA) has recently gained popularity as a novel, high-throughput assay capable of rapidly screening compounds…”
Get full text

Involvement of multiple transporters in the oral absorption of nucleoside analogues by Balimane, Praveen V., Sinko, Patrick J.

“…Many nucleoside analogues such as azt, ddI, ddC, d4T, 3TC, acv and vacv are currently being used in the treatment of patients infected with HIV, suffering from…”
Get full text

Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line by Guo, A, Hu, P, Balimane, P V, Leibach, F H, Sinko, P J

“…The results of previous work performed in our laboratory using an in situ perfusion technique in rats and rabbit apical brush border membrane vesicles have…”
Get more information

Current methodologies used for evaluation of intestinal permeability and absorption by Balimane, Praveen V, Chong, Saeho, Morrison, Richard A

“…This review article will focus on the various techniques that are currently employed by drug discovery scientists in evaluating permeability/absorption of drug…”
Get full text

Effect of ionization on the variable uptake of valacyclovir via the human intestinal peptide transporter (hPepT1) in CHO cells by Balimane, Praveen V., Sinko, Patrick J.

“…Carrier‐mediated transport of valacyclovir (vacv), the 𝓁‐valyl ester prodrug of acyclovir (acv), via the human peptide transporter (hPepT1) has been shown in…”
Get full text