Search Results - "Balez, Rachelle"

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease by Balez, Rachelle, Steiner, Nicole, Engel, Martin, Muñoz, Sonia Sanz, Lum, Jeremy Stephen, Wu, Yizhen, Wang, Dadong, Vallotton, Pascal, Sachdev, Perminder, O’Connor, Michael, Sidhu, Kuldip, Münch, Gerald, Ooi, Lezanne

“…Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease…”
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Visualization of incrementally learned projection trajectories for longitudinal data by Malepathirana, Tamasha, Senanayake, Damith, Gautam, Vini, Engel, Martin, Balez, Rachelle, Lovelace, Michael D., Sundaram, Gayathri, Heng, Benjamin, Chow, Sharron, Marquis, Christopher, Guillemin, Gilles J., Brew, Bruce, Jagadish, Chennupati, Ooi, Lezanne, Halgamuge, Saman

“…Longitudinal studies that continuously generate data enable the capture of temporal variations in experimentally observed parameters, facilitating the…”
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Neuroprotection of Neuro2a cells and the cytokine suppressive and anti-inflammatory mode of action of resveratrol in activated RAW264.7 macrophages and C8–B4 microglia by Steiner, Nicole, Balez, Rachelle, Karunaweera, Niloo, Lind, Joanne M., Münch, Gerald, Ooi, Lezanne

“…Chronic inflammation is a hallmark of neurodegenerative disease and cytotoxic levels of nitric oxide (NO) and pro-inflammatory cytokines can initiate neuronal…”
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Alzheimer's disease induced neurons bearing PSEN1 mutations exhibit reduced excitability by Maksour, Simon, Finol-Urdaneta, Rocio K, Hulme, Amy J, Cabral-da-Silva, Mauricio E Castro, Targa Dias Anastacio, Helena, Balez, Rachelle, Berg, Tracey, Turner, Calista, Sanz Muñoz, Sonia, Engel, Martin, Kalajdzic, Predrag, Lisowski, Leszek, Sidhu, Kuldip, Sachdev, Perminder S, Dottori, Mirella, Ooi, Lezanne

“…Alzheimer's disease (AD) is a devastating neurodegenerative condition that affects memory and cognition, characterized by neuronal loss and currently lacking a…”
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REST and RCOR genes display distinct expression profiles in neurons and astrocytes using 2D and 3D human pluripotent stem cell models by Maksour, Simon, Ng, Neville, Hulme, Amy J., Miellet, Sara, Engel, Martin, Muñoz, Sonia Sanz, Balez, Rachelle, Rollo, Ben, Finol-Urdaneta, Rocio K., Ooi, Lezanne, Dottori, Mirella

“…Repressor element-1 silencing transcription factor (REST) is a transcriptional repressor involved in neurodevelopment and neuroprotection. REST forms a complex…”
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A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer's Disease and Frontotemporal Dementia Disease Modeling by Muñoz, Sonia Sanz, Engel, Martin, Balez, Rachelle, Do-Ha, Dzung, Cabral-da-Silva, Mauricio Castro, Hernández, Damian, Berg, Tracey, Fifita, Jennifer A, Grima, Natalie, Yang, Shu, Blair, Ian P, Nicholson, Garth, Cook, Anthony L, Hewitt, Alex W, Pébay, Alice, Ooi, Lezanne

“…The study of neurodegenerative diseases using pluripotent stem cells requires new methods to assess neurodevelopment and neurodegeneration of specific neuronal…”
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The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation by Bax, Monique, McKenna, Jessie, Do-Ha, Dzung, Stevens, Claire H, Higginbottom, Sarah, Balez, Rachelle, Cabral-da-Silva, Mauricio E Castro, Farrawell, Natalie E, Engel, Martin, Poronnik, Philip, Yerbury, Justin J, Saunders, Darren N, Ooi, Lezanne

“…The ubiquitin proteasome system (UPS) plays an important role in regulating numerous cellular processes, and a dysfunctional UPS is thought to contribute to…”
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Viral-free generation and characterization of a human induced pluripotent stem cell line from dermal fibroblasts by Engel, Martin, Balez, Rachelle, Muñoz, Sonia Sanz, Cabral-da-Silva, Mauricio Castro, Stevens, Claire Helen, Bax, Monique, Do-Ha, Dzung, Sidhu, Kuldip, Sachdev, Perminder, Ooi, Lezanne

“…Peripheral dermal fibroblasts (DF) from a healthy 56 year old female were obtained from the Centre for Healthy Brain Ageing (CHeBA) Biobank, University of New…”
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Generation and characterization of a human induced pluripotent stem cell line UOWi005-A from dermal fibroblasts derived from a CCNFS621G familial amyotrophic lateral sclerosis patient using mRNA reprogramming by Bax, Monique, Balez, Rachelle, Muñoz, Sonia Sanz, Do-Ha, Dzung, Stevens, Claire H., Berg, Tracey, Cabral-da-Silva, Mauricio C., Engel, Martin, Nicholson, Garth, Yang, Shu, Blair, Ian P., Ooi, Lezanne

“…Dermal fibroblasts from a 59 year old male patient with amyotrophic lateral sclerosis (symptomatic at the time of collection), attributed to a mutation in the…”
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Generation and characterization of human induced pluripotent stem cell lines from a familial Alzheimer's disease PSEN1 A246E patient and a non-demented family member bearing wild-type PSEN1 by Muñoz, Sonia Sanz, Balez, Rachelle, Castro Cabral-da-Silva, Mauricio e, Berg, Tracey, Engel, Martin, Bax, Monique, Do-Ha, Dzung, Stevens, Claire H., Greenough, Mark, Bush, Ashley, Ooi, Lezanne

“…The induced pluripotent stem cell (iPSC) lines UOWi002-A and UOWi003-A were reprogrammed from dermal fibroblasts via mRNA transfection. Dermal fibroblasts from…”
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The mRNA-based reprogramming of fibroblasts from a SOD1E101G familial amyotrophic lateral sclerosis patient to induced pluripotent stem cell line UOWi007 by Balez, Rachelle, Berg, Tracey, Bax, Monique, Muñoz, Sonia Sanz, Cabral-da-Silva, Mauricio C., Engel, Martin, Do-Ha, Dzung, Stevens, Claire H., Rowe, Dominic, Yang, Shu, Blair, Ian P., Ooi, Lezanne

“…Dermal fibroblasts were donated by a 43 year old male patient with clinically diagnosed familial amyotrophic lateral sclerosis (ALS), carrying the SOD1E101G…”
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Getting to NO Alzheimer’s Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide by Balez, Rachelle, Ooi, Lezanne

“…Alzheimer’s disease (AD) is a neurodegenerative disorder involving the loss of neurons in the brain which leads to progressive memory loss and behavioral…”
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Therapeutic anti‐amyloid β antibodies cause neuronal disturbances by Adhikari, Utpal Kumar, Khan, Rizwan, Mikhael, Meena, Balez, Rachelle, David, Monique Antoinette, Mahns, David, Hardy, John, Tayebi, Mourad

“…Introduction Recent published clinical trial safety data showed that 41% of Alzheimer patients experienced amyloid‐related imaging abnormalities (ARIA), marks…”
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Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations by Greenough, Mark A., Lane, Darius J. R., Balez, Rachelle, Anastacio, Helena Targa Dias, Zeng, Zhiwen, Ganio, Katherine, McDevitt, Christopher A., Acevedo, Karla, Belaidi, Abdel Ali, Koistinaho, Jari, Ooi, Lezanne, Ayton, Scott, Bush, Ashley I.

“…Mutations in presenilin 1 and 2 ( PS1 and PS2 ) cause autosomal dominant familial Alzheimer’s disease (FAD). Ferroptosis has been implicated as a mechanism of…”
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Deep Characterisation of the sn‐Isomer Lipidome Using High‐Throughput Data‐Independent Acquisition and Ozone‐Induced Dissociation by Michael, Jesse A., Young, Reuben S. E., Balez, Rachelle, Jekimovs, Lachlan J., Marshall, David L., Poad, Berwyck L. J., Mitchell, Todd W., Blanksby, Stephen J., Ejsing, Christer S., Ellis, Shane R.

“…In recent years there has been a significant interest in the development of innovative lipidomics techniques capable of resolving lipid isomers. To date,…”
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MALDI-2-Enabled Oversampling for the Mass Spectrometry Imaging of Metabolites at Single-Cell Resolution by McKinnon, Jayden C., Balez, Rachelle, Young, Reuben S.E., Brown, Mikayla L., Lum, Jeremy S., Robinson, Liam, Belov, Mikhail E., Ooi, Lezanne, Tortorella, Sara, Mitchell, Todd W., Ellis, Shane R.

“…Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can provide valuable insights into the metabolome of complex biological…”
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If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? by Ooi, Lezanne, Dottori, Mirella, Cook, Anthony L., Engel, Martin, Gautam, Vini, Grubman, Alexandra, Hernández, Damián, King, Anna E., Maksour, Simon, Targa Dias Anastacio, Helena, Balez, Rachelle, Pébay, Alice, Pouton, Colin, Valenzuela, Michael, White, Anthony, Williamson, Robert

“…Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a public fascination with cerebral…”
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The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis by Davidson, Jennilee M., Wu, Sharlynn S. L., Rayner, Stephanie L., Cheng, Flora, Duncan, Kimberley, Russo, Carlo, Newbery, Michelle, Ding, Kunjie, Scherer, Natalie M., Balez, Rachelle, García-Redondo, Alberto, Rábano, Alberto, Rosa-Fernandes, Livia, Ooi, Lezanne, Williams, Kelly L., Morsch, Marco, Blair, Ian P., Di Ieva, Antonio, Yang, Shu, Chung, Roger S., Lee, Albert

“…Amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD)-linked mutations in CCNF have been shown to cause dysregulation to protein homeostasis…”
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Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry by Bruinen, Anne L., Fisher, Gregory L., Balez, Rachelle, van der Sar, Astrid M., Ooi, Lezanne, Heeren, Ron M. A.

“…A unique method for identification of biomolecular components in different biological specimens, while preserving the capability for high speed 2D and 3D…”
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Deep Characterisation of the sn‐Isomer Lipidome Using High‐Throughput Data‐Independent Acquisition and Ozone‐Induced Dissociation by Michael, Jesse A., Young, Reuben S. E., Balez, Rachelle, Jekimovs, Lachlan J., Marshall, David L., Poad, Berwyck L. J., Mitchell, Todd W., Blanksby, Stephen J., Ejsing, Christer S., Ellis, Shane R.

“…In recent years there has been a significant interest in the development of innovative lipidomics techniques capable of resolving lipid isomers. To date,…”
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