Search Results - "Balesano, Amanda"

The Role of Alcohol Dehydrogenase in Drug Metabolism: Beyond Ethanol Oxidation by Di, Li, Balesano, Amanda, Jordan, Samantha, Shi, Sophia M.

“…Alcohol dehydrogenases (ADHs) are most known for their roles in oxidation and elimination of ethanol. Although less known, ADHs also play a critical role in…”
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The Metabolism and Disposition of Brepocitinib in Humans and Characterization of the Formation Mechanism of an Aminopyridine Metabolite by Dowty, Martin E, Qiu, Ruolun, Dantonio, Alyssa, Niosi, Mark, Doran, Angela, Balesano, Amanda, Wright, Stephen W, Walker, Gregory S, Sharma, Raman

“…Brepocitinib is an oral once-daily Janus kinase 1 and Tyrosine kinase 2 selective inhibitor currently in development for the treatment of several autoimmune…”
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Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting Approach by Doran, Angela C, Burchett, Woodrow, Landers, Connor, Gualtieri, Gabrielle M, Balesano, Amanda, Eng, Heather, Dantonio, Alyssa L, Goosen, Theunis C, Obach, R Scott

“…The utility of chemical inhibitors in cytochrome P450 (CYP) reaction phenotyping is highly dependent on their selectivity and potency for their target CYP…”
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An improved method for cytochrome p450 reaction phenotyping using a sequential qualitative-then-quantitative approach by Doran, Angela C, Dantonio, Alyssa L, Gualtieri, Gabrielle M, Balesano, Amanda, Landers, Connor, Burchett, Woodrow, Goosen, Theunis C, Obach, R Scott

“…Cytochrome P450 reaction phenotyping to determine the fraction of metabolism values (f ) for individual enzymes is a standard study in the evaluation of a new…”
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The Comparison of Machine Learning and Mechanistic In Vitro–In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance by Keefer, Christopher E., Chang, George, Di, Li, Woody, Nathaniel A., Tess, David A., Osgood, Sarah M., Kapinos, Brendon, Racich, Jill, Carlo, Anthony A., Balesano, Amanda, Ferguson, Nicholas, Orozco, Christine, Zueva, Larisa, Luo, Lina

“…Accurate prediction of human pharmacokinetics (PK) remains one of the key objectives of drug metabolism and PK (DMPK) scientists in drug discovery projects…”
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Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948 by Filipski, Kevin J., Martinez-Alsina, Luis A., Reese, Matthew R., Evrard, Edelweiss, Buzon, Leanne M., Cameron, Kimberly O., Zhang, Yuan, Coffman, Karen J., Bradow, James, Kormos, Bethany L., Liu, Shenping, Knafels, John D., Sahasrabudhe, Parag V., Chen, Jie, Kalgutkar, Amit S., Bessire, Andrew J., Orozco, Christine C., Balesano, Amanda, Cerny, Matthew A., Bollinger, Eliza, Reyes, Allan R., Laforest, Brigitte, Rosado, Amy, Williams, George, Marshall, Mackenzie, Tam Neale, Kelly, Chen, Xian, Hirenallur-Shanthappa, Dinesh, Stansfield, John C., Groarke, John, Qiu, Ruolun, Karas, Spinel, Roth Flach, Rachel J., Esler, William P.

“…Inhibition of branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK), a negative regulator of branched-chain amino acid (BCAA) metabolism, is hypothesized…”
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Discovery of SARS-CoV-2 papain-like protease (PL pro ) inhibitors with efficacy in a murine infection model by Garnsey, Michelle R, Robinson, Matthew C, Nguyen, Luong T, Cardin, Rhonda, Tillotson, Joseph, Mashalidis, Ellene, Yu, Aijia, Aschenbrenner, Lisa, Balesano, Amanda, Behzadi, Amin, Boras, Britton, Chang, Jeanne S, Eng, Heather, Ephron, Andrew, Foley, Tim, Ford, Kristen K, Frick, James M, Gibson, Scott, Hao, Li, Hurst, Brett, Kalgutkar, Amit S, Korczynska, Magdalena, Lengyel-Zhand, Zsofia, Gao, Liping, Meredith, Hannah R, Patel, Nandini C, Polivkova, Jana, Rai, Devendra, Rose, Colin R, Rothan, Hussin, Sakata, Sylvie K, Vargo, Thomas R, Qi, Wenying, Wu, Huixian, Liu, Yiping, Yurgelonis, Irina, Zhang, Jinzhi, Zhu, Yuao, Zhang, Lei, Lee, Alpha A

“…Vaccines and first-generation antiviral therapeutics have provided important protection against COVID-19 caused by severe acute respiratory syndrome…”
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