Search Results - "Bale, Ambuja S"

Human health effects of trichloroethylene: key findings and scientific issues by Chiu, Weihsueh A, Jinot, Jennifer, Scott, Cheryl Siegel, Makris, Susan L, Cooper, Glinda S, Dzubow, Rebecca C, Bale, Ambuja S, Evans, Marina V, Guyton, Kathryn Z, Keshava, Nagalakshmi, Lipscomb, John C, Barone, Jr, Stanley, Fox, John F, Gwinn, Maureen R, Schaum, John, Caldwell, Jane C

“…In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed a toxicological review of…”
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A review of potential neurotoxic mechanisms among three chlorinated organic solvents by Bale, Ambuja S., Barone, Stan, Scott, Cheryl Siegel, Cooper, Glinda S.

“…The potential for central nervous system depressant effects from three widely used chlorinated solvents, trichloroethylene (TCE), perchloroethylene (PERC), and…”
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Developmental neurotoxicity of engineered nanomaterials: identifying research needs to support human health risk assessment by Powers, Christina M, Bale, Ambuja S, Kraft, Andrew D, Makris, Susan L, Trecki, Jordan, Cowden, John, Hotchkiss, Andrew, Gillespie, Patricia A

“…Increasing use of engineered nanomaterials (ENM) in consumer products and commercial applications has helped drive a rise in research related to the…”
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Human health effects of dichloromethane: key findings and scientific issues by Schlosser, Paul M, Bale, Ambuja S, Gibbons, Catherine F, Wilkins, Amina, Cooper, Glinda S

“…The U.S. EPA's Integrated Risk Information System (IRIS) completed an updated toxicological review of dichloromethane in November 2011. In this commentary we…”
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Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes by Bale, Ambuja S., Meacham, Connie A., Benignus, Vernon A., Bushnell, Philip J., Shafer, Timothy J.

“…The relative sensitivity of rats and humans to volatile organic compounds (VOCs) such as toluene (TOL) and perchloroethylene (PERC) is unknown and adds to…”
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Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts by van Thriel, Christoph, Westerink, Remco H.S., Beste, Christian, Bale, Ambuja S., Lein, Pamela J., Leist, Marcel

“…The developing nervous system is particularly vulnerable to chemical insults. Exposure to chemicals can result in neurobehavioural alterations, and these have…”
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Issues in assessing the health risks of n‐butanol by Segal, Deborah, Bale, Ambuja S., Phillips, Linda J., Sasso, Alan, Schlosser, Paul M., Starkey, C., Makris, Susan L.

“…A literature review and health effects evaluation were conducted for n‐butanol, a chemical that occurs naturally in some foods, which is an intermediate in the…”
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Human health effects of tetrachloroethylene: key findings and scientific issues by Guyton, Kathryn Z, Hogan, Karen A, Scott, Cheryl Siegel, Cooper, Glinda S, Bale, Ambuja S, Kopylev, Leonid, Barone, Stanley, Makris, Susan L, Glenn, Barbara, Subramaniam, Ravi P, Gwinn, Maureen R, Dzubow, Rebecca C, Chiu, Weihsueh A

“…The U.S. Environmental Protection Agency (EPA) completed a toxicological review of tetrachloroethylene (perchloroethylene, PCE) in February 2012 in support of…”
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Approaches to extrapolating animal toxicity data on organic solvents to public health by Bushnell, Philip J., Boyes, William K., Shafer, Timothy J., Bale, Ambuja S., Benignus, Vernon A.

“…Synthesizing information about the acute neurotoxicity of organic solvents into predictive relationships between exposure and effect in humans is difficult…”
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An overview of butanol-induced developmental neurotoxicity and the potential mechanisms related to these observed effects by Bale, Ambuja S, Lee, Janice S

“…Abstract The purpose of this article is to briefly review the published literature on the developmental neurotoxic effects, including potential mechanisms, of…”
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Insights from epidemiology into dichloromethane and cancer risk by Cooper, Glinda S, Scott, Cheryl Siegel, Bale, Ambuja S

“…Dichloromethane (methylene chloride) is a widely used chlorinated solvent. We review the available epidemiology studies (five cohort studies, 13 case-control…”
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Current drug scheduling reviews of synthetic cathinones by the U.S. drug enforcement administration by Prioleau, Cassandra, Tella, Srihari R, Walker, Michelle, Ghozland, Sandy, Fang, Li, Trecki, Jordan, Bale, Ambuja S, Polk, Artisha R, Willenbring, Daniel, Wong, Liqun L, Boos, Terrence L

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Correlating in vitro data to in vivo findings for risk assessment by Bale, Ambuja S, Kenyon, Elaina, Flynn, Thomas J, Lipscomb, John C, Mendrick, Donna L, Hartung, Thomas, Patton, Geoffrey W

“…A special session at the Toxicology and Risk Assessment Conference in Cincinnati, OH, USA in May, 2012 presented approaches expanding upon current uses of in…”
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Inhibition of neuronal nicotinic acetylcholine receptors by the abused solvent, toluene by Bale, Ambuja S, Smothers, Corigan T, Woodward, John J

“…Toluene is a representative example of a class of industrial solvents that are voluntarily inhaled as drugs of abuse. Previous data from this lab and others…”
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A proposal to facilitate weight-of-evidence assessments: Harmonization of Neurodevelopmental Environmental Epidemiology Studies (HONEES) by Youngstrom, Eric, Kenworthy, Lauren, Lipkin, Paul H, Goodman, Michael, Squibb, Katherine, Mattison, Donald R, Anthony, Laura Gutermuth, Makris, Susan L, Bale, Ambuja S, Raffaele, Kathleen C, LaKind, Judy S

“…Abstract The ability to conduct weight-of-evidence assessments to inform the evaluation of potential environmental neurotoxicants is limited by lack of…”
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Acute Toluene Exposure and Rat Visual Function in Proportion to Momentary Brain Concentration by Boyes, William K., Bercegeay, Mark, Krantz, Quentin Todd, Kenyon, Elaina M., Bale, Ambuja S., Shafer, Timothy J., Bushnell, Philip J., Benignus, Vernon A.

“…Acute exposure to toluene was assessed in two experiments to determine the relationship between brain toluene concentration and changes in neurophysiological…”
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Evaluating the NMDA-Glutamate Receptor as a Site of Action for Toluene, In Vivo by Bale, Ambuja S., Jackson, Meredith D., Krantz, Quentin Todd, Benignus, Vernon A., Bushnell, Philip J., Shafer, Timothy J., Boyes, William K.

“…Acute exposure to toluene and other volatile organic solvents results in neurotoxicity characterized by nervous system depression, cognitive and motor…”
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Developing an exposure–dose–response model for the acute neurotoxicity of organic solvents: overview and progress on in vitro models and dosimetry by Bushnell, Philip J., Shafer, Timothy J., Bale, Ambuja S., Boyes, William K., Simmons, Jane Ellen, Eklund, Christopher, Jackson, Trachette L.

“…We are developing an exposure–dose–response (EDR) model for volatile organic compounds (VOCs) to predict acute effects of VOCs on nervous system function from…”
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Role of NMDA, nicotinic, and GABA receptors in the steady-state visual-evoked potential in rats by Bale, Ambuja S., Adams, Tiffany L., Bushnell, Philip J., Shafer, Timothy J., Boyes, William K.

“…Agonists and antagonists at the NMDA, GABA, and nicotinic acetylcholine receptors were administered to adult male rats to evaluate the contribution of these…”
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Evaluation of toluene dependence and cross-sensitization to diazepam by Wiley, Jenny L, Bale, Ambuja S, Balster, Robert L

“…Acute effects of the abused inhalant toluene resemble those of CNS depressant drugs. Since abuse of toluene involves repeated use, the purpose of the present…”
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