Search Results - "Baldwin, Ronald"

Dopaminergic mechanisms of individual differences in human effort-based decision-making by Treadway, Michael T, Buckholtz, Joshua W, Cowan, Ronald L, Woodward, Neil D, Li, Rui, Ansari, M Sib, Baldwin, Ronald M, Schwartzman, Ashley N, Kessler, Robert M, Zald, David H

“…Preferences for different combinations of costs and benefits are a key source of variability in economic decision-making. However, the neurochemical basis of…”
Get full text

Dopaminergic Network Differences in Human Impulsivity by Buckholtz, Joshua W, Treadway, Michael T, Cowan, Ronald L, Woodward, Neil D, Li, Rui, Ansari, M. Sib, Baldwin, Ronald M, Schwartzman, Ashley N, Shelby, Evan S, Smith, Clarence E, Kessler, Robert M, Zald, David H

“…Dopamine (DA) has long been implicated in impulsivity, but the precise mechanisms linking human variability in DA signaling to differences in impulsive traits…”
Get full text

Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits by Ansari, M Sib, Kessler, Robert M, Cole, David, Schwartzman, Ashley N, Buckholtz, Joshua W, Shelby, Evan S, Zald, David H, Treadway, Michael T, Woodward, Neil D, Baldwin, Ronald M, Cowan, Ronald L, Li, Rui, Benning, Stephen D, Smith, Clarence E

“…Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [18F]fallypride positron emission tomography and blood oxygen…”
Get full text

2-Arylimidazo[2,1- b]benzothiazoles: A new family of amyloid binding agents with potential for PET and SPECT imaging of Alzheimer’s brain by Alagille, David, DaCosta, Herve, Baldwin, Ronald M., Tamagnan, Gilles D.

“…We designed and synthesized a small series of 2-aryl-imidazo[2,1- b]benzothiazole, representing a combination of motifs from the two most potent amyloid…”
Get full text

Midbrain Dopamine Receptor Availability Is Inversely Associated with Novelty-Seeking Traits in Humans by Zald, David H, Cowan, Ronald L, Riccardi, Patrizia, Baldwin, Ronald M, Ansari, M. Sib, Li, Rui, Shelby, Evan S, Smith, Clarence E, McHugo, Maureen, Kessler, Robert M

“…Novelty-seeking personality traits are a major risk factor for the development of drug abuse and other unsafe behaviors. Rodent models of temperament indicate…”
Get full text

Novel Selective Allosteric Activator of the M1 Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats by Jones, Carrie K, Brady, Ashley E, Davis, Albert A, Xiang, Zixiu, Bubser, Michael, Tantawy, Mohammed Noor, Kane, Alexander S, Bridges, Thomas M, Kennedy, J. Phillip, Bradley, Stefania R, Peterson, Todd E, Ansari, M. Sib, Baldwin, Ronald M, Kessler, Robert M, Deutch, Ariel Y, Lah, James J, Levey, Allan I, Lindsley, Craig W, Conn, P. Jeffrey

“…Recent studies suggest that subtype-selective activators of M(1)/M(4) muscarinic acetylcholine receptors (mAChRs) may offer a novel approach for the treatment…”
Get full text

A Thalamocorticostriatal Dopamine Network for Psychostimulant-Enhanced Human Cognitive Flexibility by Samanez-Larkin, Gregory R, Buckholtz, Joshua W, Cowan, Ronald L, Woodward, Neil D, Li, Rui, Ansari, M. Sib, Arrington, Catherine M, Baldwin, Ronald M, Smith, Clarence E, Treadway, Michael T, Kessler, Robert M, Zald, David H

“…Background Everyday life demands continuous flexibility in thought and behavior. We examined whether individual differences in dopamine function are related to…”
Get full text

The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease by Johnson, Kari A., Jones, Carrie K., Tantawy, Mohammed N., Bubser, Michael, Marvanova, Marketa, Ansari, M. Sib, Baldwin, Ronald M., Conn, P. Jeffrey, Niswender, Colleen M.

“…Metabotropic glutamate receptors (mGlus) are 7 Transmembrane Spanning Receptors (7TMs) that are differentially expressed throughout the brain and modulate…”
Get full text

Substituent Effects of N-(1,3-Diphenyl-1H-pyrazol-5-yl)benzamides on Positive Allosteric Modulation of the Metabotropic Glutamate-5 Receptor in Rat Cortical Astrocytes by de Paulis, Tomas, Hemstapat, Kamondanai, Chen, Yelin, Zhang, Yongqin, Saleh, Samir, Alagille, David, Baldwin, Ronald M, Tamagnan, Gilles D, Conn, P. Jeffrey

“…CDPPB [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide] was recently described as the first centrally active, positive allosteric modulator of rat and human…”
Get full text

Correlation of Individual Differences in Schizotypal Personality Traits With Amphetamine-Induced Dopamine Release in Striatal and Extrastriatal Brain Regions by Woodward, Neil D, Cowan, Ronald L, Park, Sohee, Ansari, M. Sib, Baldwin, Ronald M, Li, Rui, Doop, Mikisha, Kessler, Robert M, Zald, David H

“…Objective:Schizotypal personality traits are associated with schizophrenia spectrum disorders, and individuals with schizophrenia spectrum disorders…”
Get full text

Cerebral morphology and dopamine D2/D3 receptor distribution in humans: a combined [18F]fallypride and voxel-based morphometry study by Woodward, Neil D, Zald, David H, Ding, Zhaohua, Riccardi, Patrizia, Ansari, M Sib, Baldwin, Ronald M, Cowan, Ronald L, Li, Rui, Kessler, Robert M

“…The relationship between cerebral morphology and the expression of dopamine receptors has not been extensively studied in humans. Elucidation of such…”
Get full text

Increased Dopamine Transporter Availability Associated with the 9-Repeat Allele of the SLC6A3 Gene by van Dyck, Christopher H, Malison, Robert T, Jacobsen, Leslie K, Seibyl, John P, Staley, Julie K, Laruelle, Marc, Baldwin, Ronald M, Innis, Robert B, Gelernter, Joel

“…A polymorphism involving a variable number of tandem repeats (VNTR) has been described in the 3' untranslated region of the gene (SLC6A3) coding for the…”
Get full text

Molecular Imaging of Therapeutic Response to Epidermal Growth Factor Receptor Blockade in Colorectal Cancer by MANNING, H. Charles, MERCHANT, Nipun B, LA FLEUR, Bonnie, MOHAMMED NOOR TANTAWY, PETERSON, Todd E, ANSARI, M. Sib, BALDWIN, Ronald M, ROTHENBERG, Mace L, BORNHOP, Darryl J, GORE, John C, COFFEY, Robert J, COE FOUTCH, A, VIROSTKO, John M, WYATT, Shelby K, SHAH, Chirayu, MCKINLEY, Eliot T, JINGPING XIE, MUTIC, Nathan J, WASHINGTON, M. Kay

“…Purpose: To evaluate noninvasive molecular imaging methods as correlative biomarkers of therapeutic efficacy of cetuximab in human colorectal cancer cell line…”
Get full text

Synthesis and biological evaluation of positron emission tomography radiotracers targeting serotonin 4 receptors in brain: [18F]MNI-698 and [18F]MNI-699 by Caillé, Fabien, Morley, Thomas J., Tavares, Adriana Alexandre S., Papin, Caroline, Twardy, Nicole M., Alagille, David, Lee, H. Sharon, Baldwin, Ronald M., Seibyl, John P., Barret, Olivier, Tamagnan, Gilles D.

“…Two new benzodioxane derivatives were synthesized as candidates to image the serotonin 4 receptors by positron emission tomography (PET) and radiolabeled with…”
Get full text

Imaging Biomarkers Predict Response to Anti-HER2 (ErbB2) Therapy in Preclinical Models of Breast Cancer by SHAH, Chirayu, MILLER, Todd W, BALDWIN, Ronald M, GORE, John C, SCHIFF, Rachel, ARTEAGA, Carlos L, MANNING, H. Charles, WYATT, Shelby K, MCKINLEY, EliotT, GRACIELA OLIVARES, Maria, SANCHEZ, Violeta, NOLTING, Donald D, BUCK, Jason R, PING ZHAO, SIB ANSARI, M

“…Purpose: To evaluate noninvasive imaging methods as predictive biomarkers of response to trastuzumab in mouse models of HER2-overexpressing breast cancer. The…”
Get full text

Asymmetric Synthesis of (+)-(S,S)-Reboxetine via a New (S)-2-(Hydroxymethyl)morpholine Preparation by Brenner, Eric, Baldwin, Ronald M, Tamagnan, Gilles

“…(S,S)-Reboxetine was synthesized stereospecifically in 30% overall yield and 99% ee in eight steps. Key steps were selective oxidation of an N-protected…”
Get full text

Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands by Virostko, John, Henske, Joseph, Vinet, Laurent, Lamprianou, Smaragda, Dai, Chunhua, Radhika, Aramandla, Baldwin, Ronald M, Ansari, Mohammad S, Hefti, Franz, Skovronsky, Daniel, Kung, Hank F, Herrera, Pedro L, Peterson, Todd E, Meda, Paolo, Powers, Alvin C

“…We combined multimodal imaging (bioluminescence, X-ray computed tomography, and PET), tomographic reconstruction of bioluminescent sources, and two unique,…”
Get full text

Comparison of delayed matching-to-sample performance in monkeys and children by Chelonis, John J., Cox, Andrew R., Karr, Michael J., Prunty, Patricia K., Baldwin, Ronald L., Paule, Merle G.

“…•The forgetting rates for monkeys were most comparable to that of younger children.•Younger children exhibited less proactive interference than older…”
Get full text

Sex differences in the relationship of regional dopamine release to affect and cognitive function in striatal and extrastriatal regions using positron emission tomography and [18F]fallypride by Riccardi, Patrizia, Park, Sohee, Anderson, Sharlet, Doop, Mikisha, Ansari, M. Sib, Schmidt, Dennis, Baldwin, Ronald

“…The purpose of this study was to examine sex differences in the correlations of d‐amphetamine (d‐AMPH) induced displacements of [18F]fallypride in striatal and…”
Get full text

Amphetamine-Induced Displacement of [ F] Fallypride in Striatum and Extrastriatal Regions in Humans by RICCARDI, Patrizia, RUI LI, SCHMIDT, Dennis, BALDWIN, Ronald, KESSLER, Robert, MOHAMMAD SIB ANSARI, ZALD, David, PARK, Sohee, DAWANT, Benoit, ANDERSON, Sharlet, DOOP, Mikisha, WOODWARD, Neil, SCHOENBERG, Evan

“…This study examined D-amphetamine (D-AMPH)-induced displacements of [18F] fallypride in striatal and extrastriatal regions and the correlations of these…”
Get full text