Search Results - "Baldus, John E"

Discovery of N‑(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)‑5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)‑2H‑tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis by Ruminski, Peter G, Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E, Schmidt, Michelle, Scholten, Jeffrey A, Fletcher, Theresa R, Hamper, Bruce C, Carroll, Jeffery N, Shieh, Huey S, Caspers, Nicole, Collins, Brandon, Grapperhaus, Margaret, Palmquist, Katherine E, Collins, Joe, Baldus, John E, Hitchcock, Jeffrey, Kleine, H. Peter, Rogers, Michael D, McDonald, Joseph, Munie, Grace E, Messing, Dean M, Portolan, Silvia, Whiteley, Laurence O, Sunyer, Teresa, Schnute, Mark E

“…Matrix metalloproteinase-13 (MMP-13) is a zinc-dependent protease responsible for the cleavage of type II collagen, the major structural protein of articular…”
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Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition by Jerome, Kevin D., Rucker, Paul V., Xing, Li, Shieh, Huey S., Baldus, John E., Selness, Shaun R., Letavic, Michael A., Braganza, John F., McClure, Kim F.

“…The structure based drug design, synthesis and structure–activity relationship of a series of C6 sulfur linked triazolopyridine based p38 inhibitors are…”
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Discovery of 5-substituted- N-arylpyridazinones as inhibitors of p38 MAP kinase by Jerome, Kevin D., Hepperle, Michael E., Walker, John K., Xing, Li, Devraj, Rajesh V., Benson, Alan G., Baldus, John E., Selness, Shaun R.

“…The synthesis, structure–activity relationship and modeling of a series of 5-substituted- N-aryl pyridazinone based p38α inhibitors are described. In comparing…”
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Discovery of N -(4-Fluoro-3-methoxybenzyl)-6-(2-(((2 S ,5 R )-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2 H -tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis by Ruminski, Peter G., Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E., Schmidt, Michelle, Scholten, Jeffrey A., Fletcher, Theresa R., Hamper, Bruce C., Carroll, Jeffery N., Shieh, Huey S., Caspers, Nicole, Collins, Brandon, Grapperhaus, Margaret, Palmquist, Katherine E., Collins, Joe, Baldus, John E., Hitchcock, Jeffrey, Kleine, H. Peter, Rogers, Michael D., McDonald, Joseph, Munie, Grace E., Messing, Dean M., Portolan, Silvia, Whiteley, Laurence O., Sunyer, Teresa, Schnute, Mark E.

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