Search Results - "Balduini Cesare"

Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A by Malara, Alessandro, Gruppi, Cristian, Rebuzzini, Paola, Visai, Livia, Perotti, Cesare, Moratti, Remigio, Balduini, Cesare, Tira, Maria Enrica, Balduini, Alessandra

“…The mechanisms by which megakaryocytes (MKs) differentiate and release platelets into the circulation are not well understood. However, growing evidence…”
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Biocompatibility of functionalized boron phosphate (BPO4 ) nanoparticles for boron neutron capture therapy (BNCT) application by Achilli, Cesare, PhD, Grandi, Stefania, PhD, Ciana, Annarita, PhD, Guidetti, Gianni F., PhD, Malara, Alessandro, PhD, Abbonante, Vittorio, PhD, Cansolino, Laura, PhD, Tomasi, Corrado, PhD, Balduini, Alessandra, MD, Fagnoni, Maurizio, PhD, Merli, Daniele, PhD, Mustarelli, Piercarlo, PhD, Canobbio, Ilaria, PhD, Balduini, Cesare, MD, Minetti, Giampaolo, PhD

“…Abstract Boron neutron capture therapy (BNCT) is a radiotherapy treatment based on the accumulation in the tumor of a10 B-containing drug and subsequent…”
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Impaired thrombin-induced platelet activation and thrombus formation in mice lacking the Ca2+-dependent tyrosine kinase Pyk2 by Canobbio, Ilaria, Cipolla, Lina, Consonni, Alessandra, Momi, Stefania, Guidetti, Gianni, Oliviero, Barbara, Falasca, Marco, Okigaki, Mitsuhiko, Balduini, Cesare, Gresele, Paolo, Torti, Mauro

“…In the present study, we used a knockout murine model to analyze the contribution of the Ca2+-dependent focal adhesion kinase Pyk2 in platelet activation and…”
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Susceptibility to hydrolysis of phenylboronic pinacol esters at physiological pH by Achilli Cesare, Ciana Annarita, Fagnoni Maurizio, Balduini Cesare, Minetti Giampaolo

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Nanoparticles induce platelet activation in vitro through stimulation of canonical signalling pathways by Guidetti, Gianni F., PhD, Consonni, Alessandra, PhD, Cipolla, Lina, PhD, Mustarelli, Piercarlo, PhD, Balduini, Cesare, MD, Torti, Mauro, PhD

“…Abstract Nanomaterials are attracting growing interest for their potential use in several applications as nanomedicine; therefore, the analysis of their…”
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The Gi-coupled P2Y12 Receptor Regulates Diacylglycerol-mediated Signaling in Human Platelets by Guidetti, Gianni F., Lova, Paolo, Bernardi, Bruno, Campus, Francesca, Baldanzi, Gianluca, Graziani, Andrea, Balduini, Cesare, Torti, Mauro

“…Stimulation of Gq-coupled receptors activates phospholipase C and is supposed to promote both intracellular Ca2+ mobilization and protein kinase C (PKC)…”
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A Gi-dependent Pathway Is Required for Activation of the Small GTPase Rap1B in Human Platelets by Lova, Paolo, Paganini, Simona, Sinigaglia, Fabiola, Balduini, Cesare, Torti, Mauro

“…Stimulation of human platelets by cross-linking of the low affinity receptor for immunoglobulin, FcγRIIA, caused the rapid activation of the small GTPase…”
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Thrombin induces platelet activation in the absence of functional protease activated receptors 1 and 4 and glycoprotein Ib-IX-V by Lova, Paolo, Canobbio, Ilaria, Guidetti, Gianni F., Balduini, Cesare, Torti, Mauro

“…Three different surface receptors mediate thrombin-induced activation and aggregation of human blood platelets: the protease activated receptors 1 and 4 (PAR1…”
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A Selective Role for Phosphatidylinositol 3,4,5-Trisphosphate in the Gi-dependent Activation of Platelet Rap1B by Lova, Paolo, Paganini, Simona, Hirsch, Emilio, Barberis, Laura, Wymann, Matthias, Sinigaglia, Fabiola, Balduini, Cesare, Torti, Mauro

“…The small GTP-binding protein Rap1B is activated in human platelets upon stimulation of a Gi-dependent signaling pathway. In this work, we found that…”
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Contribution of Protease-activated Receptors 1 and 4 and Glycoprotein Ib-IX-V in the Gi-independent Activation of Platelet Rap1B by Thrombin by Lova, Paolo, Campus, Francesca, Lombardi, Rossana, Cattaneo, Marco, Sinigaglia, Fabiola, Balduini, Cesare, Torti, Mauro

“…Thrombin activates human platelets through three different membrane receptors, the protease-activated receptors PAR-1 and PAR-4 and the glycoprotein Ib…”
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Neutrophil granulocytes uniquely express, among human blood cells, high levels of Methionine-sulfoxide-reductase enzymes by Achilli, Cesare, Ciana, Annarita, Rossi, Antonio, Balduini, Cesare, Minetti, Giampaolo

“…L‐Methionine (Met), in its free form or when inserted in proteins, is sensitive to oxidation of its thioether group by reactive oxygen species from exogenous…”
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A role for p38 MAP kinase in platelet activation by von Willebrand factor by Canobbio, Ilaria, Reineri, Stefania, Sinigaglia, Fabiola, Balduini, Cesare, Torti, Mauro

“…Platelet activation induced by von Willebrand factor (VWF) binding to the membrane GPIb-IX-V receptor involves multiple signal transduction pathways. Among…”
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The small proteoglycan decorin supports adhesion and activation of human platelets by Guidetti, Gianni, Bertoni, Alessandra, Viola, Manuela, Tira, Enrica, Balduini, Cesare, Torti, Mauro

“…Decorin is a small leucine-rich proteoglycan able to interact with several molecules of the subendothelial matrix, such as collagen and fibronectin. In this…”
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Binding of von Willebrand factor to the small proteoglycan decorin by Guidetti, Gianni F., Bartolini, Barbara, Bernardi, Bruno, Tira, Maria E., Berndt, Michael C., Balduini, Cesare, Torti, Mauro

“…The small proteoglycan decorin plays an important role in the organisation of the extracellular matrix by binding to several components, including collagen and…”
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Proline-rich tyrosine kinase 2 and focal adhesion kinase are involved in different phases of platelet activation by vWF by Canobbio, Ilaria, Lova, Paolo, Sinigaglia, Fabiola, Balduini, Cesare, Torti, Mauro

“…Stimulation of human platelets with von Willebrand factor (vWF) induces the rapid tyrosine phosphorylation of several proteins, but very little is known on the…”
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Genetic evidence for a predominant role of PI3Kβ catalytic activity in ITAM- and integrin-mediated signaling in platelets by Canobbio, Ilaria, Stefanini, Lucia, Cipolla, Lina, Ciraolo, Elisa, Gruppi, Cristian, Balduini, Cesare, Hirsch, Emilio, Torti, Mauro

“…Phosphatidylinositol 3-kinase (PI3K) isoforms PI3Kβ and PI3Kγ are implicated in platelet adhesion, activation, and aggregation, but their relative contribution…”
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The Plant Hormone Abscisic Acid Is a Prosurvival Factor in Human and Murine Megakaryocytes by Malara, Alessandro, Fresia, Chiara, Di Buduo, Christian Andrea, Soprano, Paolo Maria, Moccia, Francesco, Balduini, Cesare, Zocchi, Elena, De Flora, Antonio, Balduini, Alessandra

“…Abscisic acid (ABA) is a phytohormone involved in pivotal physiological functions in higher plants. Recently, ABA has been proven to be also secreted and…”
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Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling by Consonni, Alessandra, Cipolla, Lina, Guidetti, Gianni, Canobbio, Ilaria, Ciraolo, Elisa, Hirsch, Emilio, Falasca, Marco, Okigaki, Mitsuhiko, Balduini, Cesare, Torti, Mauro

“…Integrin α2β1–mediated adhesion of human platelets to monomeric type I collagen or to the GFOGER peptide caused a time-dependent activation of PI3K and Akt…”
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On the association of lipid rafts to the spectrin skeleton in human erythrocytes by Ciana, Annarita, Achilli, Cesare, Balduini, Cesare, Minetti, Giampaolo

“…Lipid rafts are local inhomogeneities in the composition of the plasma membrane of living cells, that are enriched in sphingolipids and cholesterol in a…”
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Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca(2+)-dependent activation of platelet Rap1b GTPase by Guidetti, Gianni Francesco, Manganaro, Daria, Consonni, Alessandra, Canobbio, Ilaria, Balduini, Cesare, Torti, Mauro

“…In blood platelets the small GTPase Rap1b is activated by cytosolic Ca2+ and promotes integrin αIIbβ3 inside-out activation and platelet aggregation. cAMP is…”
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