Search Results - "Baldomero M. Olivera"

Characterization of the Conus bullatus genome and its venom-duct transcriptome by Hu, Hao, Bandyopadhyay, Pradip K, Olivera, Baldomero M, Yandell, Mark

“…The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high…”
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Specialized insulin is used for chemical warfare by fish-hunting cone snails by Safavi-Hemami, Helena, Gajewiak, Joanna, Karanth, Santhosh, Robinson, Samuel D., Ueberheide, Beatrix, Douglass, Adam D., Schlegel, Amnon, Imperial, Julita S., Watkins, Maren, Bandyopadhyay, Pradip K., Yandell, Mark, Li, Qing, Purcell, Anthony W., Norton, Raymond S., Ellgaard, Lars, Olivera, Baldomero M.

“…More than 100 species of venomous cone snails (genus Conus ) are highly effective predators of fish. The vast majority of venom components identified and…”
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Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct by Hu, Hao, Bandyopadhyay, Pradip K, Olivera, Baldomero M, Yandell, Mark

“…The fish-hunting cone snail, Conus geographus, is the deadliest snail on earth. In the absence of medical intervention, 70% of human stinging cases are fatal…”
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Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa by Safavi-Hemami, Helena, Lu, Aiping, Li, Qing, Fedosov, Alexander E, Biggs, Jason, Showers Corneli, Patrice, Seger, Jon, Yandell, Mark, Olivera, Baldomero M

“…A specialized insulin was recently found in the venom of a fish-hunting cone snail, Conus geographus Here we show that many worm-hunting and snail-hunting…”
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Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel NaV1.7 by Kimball, Ian H., Nguyen, Phuong T., Olivera, Baldomero M., Sack, Jon T., Yarov-Yarovoy, Vladimir

“…The voltage-gated sodium (Na V ) channel subtype Na V 1.7 plays a critical role in pain signaling, making it an important drug target. Here we studied the…”
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Fish-hunting cone snail disrupts prey’s glucose homeostasis with weaponized mimetics of somatostatin and insulin by Yeung, Ho Yan, Ramiro, Iris Bea L., Andersen, Daniel B., Koch, Thomas Lund, Hamilton, Alexander, Bjørn-Yoshimoto, Walden E., Espino, Samuel, Vakhrushev, Sergey Y., Pedersen, Kasper B., de Haan, Noortje, Hipgrave Ederveen, Agnes L., Olivera, Baldomero M., Knudsen, Jakob G., Bräuner-Osborne, Hans, Schjoldager, Katrine T., Holst, Jens Juul, Safavi-Hemami, Helena

“…Venomous animals have evolved diverse molecular mechanisms to incapacitate prey and defend against predators. Most venom components disrupt nervous, locomotor,…”
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Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides by Safavi-Hemami, Helena, Li, Qing, Jackson, Ronneshia L., Song, Albert S., Boomsma, Wouter, Bandyopadhyay, Pradip K., Gruber, Christian W., Purcell, Anthony W., Yandell, Mark, Olivera, Baldomero M., Ellgaard, Lars

“…Formation of correct disulfide bonds in the endoplasmic reticulum is a crucial step for folding proteins destined for secretion. Protein disulfide isomerases…”
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Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus by Aman, Joseph W., Imperial, Julita S., Ueberheide, Beatrix, Zhang, Min-Min, Aguilar, Manuel, Taylor, Dylan, Watkins, Maren, Yoshikami, Doju, Showers-Corneli, Patrice, Safavi-Hemami, Helena, Biggs, Jason, Teichert, Russell W., Olivera, Baldomero M.

“…Significance Only rarely is it possible to reconstruct molecular events that trigger the radiation of new lineages. Here we report key evidence that allows…”
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Elucidation of Medusozoan (Jellyfish) Venom Constituent Activities Using Constellation Pharmacology by Yanagihara, Angel A, Giglio, Matías L, Hurwitz, Kikiana, Kadler, Raechel, Espino, Samuel S, Raghuraman, Shrinivasan, Olivera, Baldomero M

“…Within the phylum Cnidaria, sea anemones (class Anthozoa) express a rich diversity of ion-channel peptide modulators with biomedical applications, but…”
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Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass by Teichert, Russell W., Memon, Tosifa, Aman, Joseph W., Olivera, Baldomero M.

“…Change is intrinsic to nervous systems; change is required for learning and conditioning and occurs with disease progression, normal development, and aging. To…”
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Metabolic model for diversity-generating biosynthesis by Tianero, Ma. Diarey, Pierce, Elizabeth, Raghuraman, Shrinivasan, Sardar, Debosmita, McIntosh, John A., Heemstra, John R., Schonrock, Zachary, Covington, Brett C., Maschek, J. Alan, Cox, James E., Bachmann, Brian O., Olivera, Baldomero M., Ruffner, Duane E., Schmidt, Eric W.

“…A conventional metabolic pathway leads to a specific product. In stark contrast, there are diversity-generating metabolic pathways that naturally produce…”
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A toxin-based approach to neuropeptide and peptide hormone discovery by Koch, Thomas Lund, Torres, Joshua P., Baskin, Robert P., Salcedo, Paula Flórez, Chase, Kevin, Olivera, Baldomero M., Safavi-Hemami, Helena

“…Peptide hormones and neuropeptides form a diverse class of bioactive secreted molecules that control essential processes in animals. Despite breakthroughs in…”
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Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus by Neves, Jorge L B, Urcino, Cristoval, Chase, Kevin, Dowell, Cheryl, Hone, Arik J, Morgenstern, David, Chua, Victor M, Ramiro, Iris Bea L, Imperial, Julita S, Leavitt, Lee S, Phan, Jasmine, Fisher, Fernando A, Watkins, Maren, Raghuraman, Shrinivasan, Tun, Jortan O, Ueberheide, Beatrix M, McIntosh, J Michael, Vasconcelos, Vitor, Olivera, Baldomero M, Gajewiak, Joanna

“…The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx)…”
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Integrated Oxidative Folding of Cysteine/Selenocysteine Containing Peptides: Improving Chemical Synthesis of Conotoxins by Walewska, Aleksandra, Zhang, Min-Min, Skalicky, Jack J, Yoshikami, Doju, Olivera, Baldomero M, Bulaj, Grzegorz

“…Building bridges: The use of diselenide and selectively (¹⁵N/¹³C)-labeled disulfide bridges is combined to give improvements in oxidative folding and disulfide…”
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Characterization of two neuronal subclasses through constellation pharmacology by Teichert, Russell W, Raghuraman, Shrinivasan, Memon, Tosifa, Cox, Jeffrey L, Foulkes, Tucker, Rivier, Jean E, Olivera, Baldomero M

“…Different types of neurons diverge in function because they express their own unique set or constellation of signaling molecules, including receptors and ion…”
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Reagentless Oxidative Folding of Disulfide-Rich Peptides Catalyzed by an Intramolecular Diselenide by Steiner, Andrew M., Woycechowsky, Kenneth J., Olivera, Baldomero M., Bulaj, Grzegorz

“…Building bridges: In cysteine‐rich peptides, diselenides can be used as a proxy for disulfide bridges as the energetic preference for SeSe bonds over mixed…”
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The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea by Robinson, Samuel D, Li, Qing, Lu, Aiping, Bandyopadhyay, Pradip K, Yandell, Mark, Olivera, Baldomero M, Safavi-Hemami, Helena

“…The marine cone snail Conus gloriamaris is an iconic species. For over two centuries, its shell was one of the most prized and valuable natural history objects…”
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Integrating Venom Peptide Libraries Into a Phylogenetic and Broader Biological Framework by Chase, Kevin, Watkins, Maren, Safavi-Hemami, Helena, Olivera, Baldomero M

“…The venomous marine snails are conventionally divided into three groups, the cone snails (family Conidae), the auger snails (family Terebridae) and the turrids…”
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Characterization of the First Conotoxin from Conus ateralbus , a Vermivorous Cone Snail from the Cabo Verde Archipelago by Neves, Jorge L B, Imperial, Julita S, Morgenstern, David, Ueberheide, Beatrix, Gajewiak, Joanna, Antunes, Agostinho, Robinson, Samuel D, Espino, Samuel, Watkins, Maren, Vasconcelos, Vitor, Olivera, Baldomero M

“…is a cone snail endemic to the west side of the island of Sal, in the Cabo Verde Archipelago off West Africa. We describe the isolation and characterization of…”
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Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research by Bjørn-Yoshimoto, Walden E, Ramiro, Iris Bea L, Yandell, Mark, McIntosh, J Michael, Olivera, Baldomero M, Ellgaard, Lars, Safavi-Hemami, Helena

“…Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine cone snails. Decades of conotoxin research have provided numerous…”
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