Search Results - "Baldock, Robert A."

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair by Lu, Wei-Ting, Hawley, Ben R., Skalka, George L., Baldock, Robert A., Smith, Ewan M., Bader, Aldo S., Malewicz, Michal, Watts, Felicity Z., Wilczynska, Ania, Bushell, Martin

“…The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of…”
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Hydroquinine: a potential new avenue in drug discovery for drug-resistant bacteria? by Jongjitwimol, Jirapas, Baldock, Robert A

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ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX by Baldock, Robert A., Day, Matthew, Wilkinson, Oliver J., Cloney, Ross, Jeggo, Penelope A., Oliver, Antony W., Watts, Felicity Z., Pearl, Laurence H.

“…53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin…”
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Sumoylation of eIF4A2 affects stress granule formation by Jongjitwimol, Jirapas, Baldock, Robert A, Morley, Simon J, Watts, Felicity Z

“…Regulation of protein synthesis is crucial for cells to maintain viability and to prevent unscheduled proliferation that could lead to tumorigenesis. Exposure…”
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Evolution-based screening enables genome-wide prioritization and discovery of DNA repair genes by Brunette, Gregory J., Jamalruddin, Mohd A., Baldock, Robert A., Clark, Nathan L., Bernstein, Kara A.

“…DNA repair is critical for genome stability and is maintained through conserved pathways. Traditional genome-wide mammalian screens are both expensive and…”
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Hydroquinine Inhibits the Growth of Multidrug-Resistant Pseudomonas aeruginosa via the Suppression of the Arginine Deiminase Pathway Genes by Weawsiangsang, Sattaporn, Rattanachak, Nontaporn, Jongjitvimol, Touchkanin, Jaifoo, Theerasak, Charoensit, Pensri, Viyoch, Jarupa, Ross, Sukunya, Ross, Gareth M., Baldock, Robert A., Jongjitwimol, Jirapas

“…Hydroquinine has antimicrobial potential with demonstrated activity against several bacteria, including multidrug-resistant (MDR) P. aeruginosa reference…”
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Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint by Bigot, Nicolas, Day, Matthew, Baldock, Robert A, Watts, Felicity Z, Oliver, Antony W, Pearl, Laurence H

“…Coordination of the cellular response to DNA damage is organised by multi-domain 'scaffold' proteins, including 53BP1 and TOPBP1, which recognise…”
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Hydroquinine possesses antibacterial activity, and at half the mic, induces the overexpression of RND-type efflux pumps using multiplex digital PCR in Pseudomonas Aeruginosa by Rattanachak, Nontaporn, Weawsiangsang, Sattaporn, Jongjitvimol, Touchkanin, Baldock, Robert A, Jongjitwimol, Jirapas

“…Hydroquinine is an organic compound that is closely related to quinine-derivative drugs and contains anti-malarial and anti-arrhythmia activities. It has been…”
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Hydroquinine Enhances the Efficacy of Contact Lens Solutions for Inhibiting Pseudomonas aeruginosa Adhesion and Biofilm Formation by Weawsiangsang, Sattaporn, Rattanachak, Nontaporn, Ross, Sukunya, Ross, Gareth M, Baldock, Robert A, Jongjitvimol, Touchkanin, Jongjitwimol, Jirapas

“…is one of the most common bacteria causing contact lens-related microbial keratitis (CLMK). Previous studies report that disinfecting solutions were…”
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Use of augmented reality (AR) to aid bioscience education and enrich student experience by Reeves, Laura E., Bolton, Edward, Bulpitt, Matthew, Scott, Alex, Tomey, Ian, Gates, Micah, Baldock, Robert A.

“…In recent years, development of new technologies designed to enhance user experience have accelerated, often being used in modern media such as in films and…”
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A Novel and Quantitative Detection Assay (effluxR) for Identifying Efflux-Associated Resistance Genes Using Multiplex Digital PCR in Clinical Isolates of Pseudomonas aeruginosa by Rattanachak, Nontaporn, Weawsiangsang, Sattaporn, Baldock, Robert A., Jaifoo, Theerasak, Jongjitvimol, Touchkanin, Jongjitwimol, Jirapas

“…The rise of multidrug resistance of Pseudomonas aeruginosa highlights an increased need for selective and precise antimicrobial treatment. Drug efflux pumps…”
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High-Throughput Transcriptomic Profiling Reveals the Inhibitory Effect of Hydroquinine on Virulence Factors in Pseudomonas aeruginosa by Rattanachak, Nontaporn, Weawsiangsang, Sattaporn, Daowtak, Krai, Thongsri, Yordhathai, Ross, Sukunya, Ross, Gareth, Nilsri, Nungruthai, Baldock, Robert A, Pongcharoen, Sutatip, Jongjitvimol, Touchkanin, Jongjitwimol, Jirapas

“…Hydroquinine is an organic alkaloid compound that exhibits antimicrobial activity against several bacterial strains including strains of both drug-sensitive…”
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Beyond base excision repair: an evolving picture of mitochondrial DNA repair by Allkanjari, Kathrin, Baldock, Robert A

“…Mitochondria are highly specialised organelles required for key cellular processes including ATP production through cellular respiration and controlling cell…”
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RAD51 paralog function in replicative DNA damage and tolerance by Rein, Hayley L, Bernstein, Kara A, Baldock, Robert A

“…RAD51 paralog gene mutations are observed in both hereditary breast and ovarian cancers. Classically, defects in RAD51 paralog function are associated with…”
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Fluoroquinolones: old drugs, putative new toxicities by Bove, Cecilia, Baldock, Robert A, Champigneulle, Oscar, Martin, Linda, Bennett, Charles L

“…Fluoroquinolone (FQ) antibiotics were approved in 1986 for treatment of urinary tract infections, sinusitis, and bronchitis. Numerous putative FQ-associated…”
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Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection by Densham, Ruth M, Garvin, Alexander J, Stone, Helen R, Strachan, Joanna, Baldock, Robert A, Daza-Martin, Manuel, Fletcher, Alice, Blair-Reid, Sarah, Beesley, James, Johal, Balraj, Pearl, Laurence H, Neely, Robert, Keep, Nicholas H, Watts, Felicity Z, Morris, Joanna R

“…The E3 ubiquitin ligase activity of the BRCA1–BARD1 complex is required to reposition 53BP1 on damaged chromatin and to promote DNA resection and repair via…”
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RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination by Baldock, Robert A., Pressimone, Catherine A., Baird, Jared M., Khodakov, Anton, Luong, Thong T., Grundy, McKenzie K., Smith, Chelsea M., Karpenshif, Yoav, Bratton-Palmer, Dominique S., Prakash, Rohit, Jasin, Maria, Garcin, Edwige B., Gon, Stéphanie, Modesti, Mauro, Bernstein, Kara A.

“…•Only RAD51D isoform 1 rescues HR-deficiency observed in RAD51D knock-out cell lines.•The RAD51D Walker A motif is important for its HR-function and…”
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Abstract A02: Investigating the contribution of RAD51 paralog mutations to cancer development by Baldock, Robert A., Pressimone, Catherine A., Bernstein, Kara A.

“…Homologous recombination (HR) is a high-fidelity DNA repair mechanism that utilizes a homologous template to repair double-strand breaks (DSBs). The defining…”
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Hydroquinine Inhibits the Growth of Multidrug-Resistant IPseudomonas aeruginosa/I via the Suppression of the Arginine Deiminase Pathway Genes by Weawsiangsang, Sattaporn, Rattanachak, Nontaporn, Jongjitvimol, Touchkanin, Jaifoo, Theerasak, Charoensit, Pensri, Viyoch, Jarupa, Ross, Sukunya, Ross, Gareth M, Baldock, Robert A, Jongjitwimol, Jirapas

“…Hydroquinine has antimicrobial potential with demonstrated activity against several bacteria, including multidrug-resistant (MDR) P. aeruginosa reference…”
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Hydroquinine Enhances the Efficacy of Contact Lens Solutions for Inhibiting IPseudomonas aeruginosa/I Adhesion and Biofilm Formation by Weawsiangsang, Sattaporn, Rattanachak, Nontaporn, Ross, Sukunya, Ross, Gareth M, Baldock, Robert A, Jongjitvimol, Touchkanin, Jongjitwimol, Jirapas

“…P. aeruginosa is one of the most common bacteria causing contact lens-related microbial keratitis (CLMK). Previous studies report that disinfecting solutions…”
Get full text