Search Results - "Balci, Hamza"

G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding by Ray, Sujay, Bandaria, Jigar N, Qureshi, Mohammad H, Yildiz, Ahmet, Balci, Hamza

“…Human telomeres terminate with a single-stranded 3′ G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of…”
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Direct imaging of single UvrD helicase dynamics on long single-stranded DNA by Lee, Kyung Suk, Balci, Hamza, Jia, Haifeng, Lohman, Timothy M., Ha, Taekjip

“…Fluorescence imaging of single-protein dynamics on DNA has been largely limited to double-stranded DNA or short single-stranded DNA. We have developed a hybrid…”
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Three-Dimensional Particle Tracking via Bifocal Imaging by Toprak, Erdal, Balci, Hamza, Blehm, Benjamin H, Selvin, Paul R

“…We introduce a bifocal imaging method that enables three-dimensional (3D) tracking of both fluorescent and nonfluorescent particles. We accomplish this by…”
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Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase by Maleki, Parastoo, Mustafa, Golam, Gyawali, Prabesh, Budhathoki, Jagat B, Ma, Yue, Nagasawa, Kazuo, Balci, Hamza

“…Abstract G-quadruplex (GQ) stabilizing small molecule (SM) ligands have been used to stabilize human telomeric GQ (hGQ) to inhibit telomerase activity, or…”
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A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions by Maleki, Parastoo, Ma, Yue, Iida, Keisuke, Nagasawa, Kazuo, Balci, Hamza

“…The potential use of G-quadruplex (GQ) stabilizing small molecules as anti-cancer drugs has created a flurry of activity on various aspects of these molecules…”
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RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP by Budhathoki, Jagat B, Ray, Sujay, Urban, Vaclav, Janscak, Pavel, Yodh, Jaya G, Balci, Hamza

“…Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadruplex (GQ) structures, which otherwise result in genomic…”
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A practical guide to studying G-quadruplex structures using single-molecule FRET by Maleki, Parastoo, Budhathoki, Jagat B., Roy, William A., Balci, Hamza

“…In this article, we summarize the knowledge and best practices learned from bulk and single-molecule measurements to address some of the frequently experienced…”
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Rtt105 regulates RPA function by configurationally stapling the flexible domains by Kuppa, Sahiti, Deveryshetty, Jaigeeth, Chadda, Rahul, Mattice, Jenna R., Pokhrel, Nilisha, Kaushik, Vikas, Patterson, Angela, Dhingra, Nalini, Pangeni, Sushil, Sadauskas, Marisa K., Shiekh, Sajad, Balci, Hamza, Ha, Taekjip, Zhao, Xiaolan, Bothner, Brian, Antony, Edwin

“…Replication Protein A (RPA) is a heterotrimeric complex that binds to single-stranded DNA (ssDNA) and recruits over three dozen RPA-interacting proteins to…”
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RPA-Mediated Unfolding of Systematically Varying G-Quadruplex Structures by Ray, Sujay, Qureshi, Mohammad H., Malcolm, Dominic W., Budhathoki, Jagat B., Çelik, Uğur, Balci, Hamza

“…G-quadruplex (GQ) is a noncanonical nucleic acid structure that is formed by guanine rich sequences. Unless it is destabilized by proteins such as replication…”
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A Comparative Study of G-Quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 Helicase by Budhathoki, Jagat B., Maleki, Parastoo, Roy, William A., Janscak, Pavel, Yodh, Jaya G., Balci, Hamza

“…RECQ5 is one of five members of the RecQ family of helicases in humans, which include RECQ1, Bloom (BLM), Werner (WRN), RECQ4, and RECQ5. Both WRN and BLM have…”
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Impact of Small Molecules on Intermolecular G-Quadruplex Formation by Gyawali, Prabesh, Gc, Keshav, Ma, Yue, Abeysirigunawardena, Sanjaya, Nagasawa, Kazuo, Balci, Hamza

“…We performed single molecule studies to investigate the impact of several prominent small molecules (the oxazole telomestatin derivative L2H2-6OTD,…”
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A single molecule investigation of i-motif stability, folding intermediates, and potential as in-situ pH sensor by Mustafa, Golam, Gyawali, Prabesh, Taylor, Jacob A, Maleki, Parastoo, Nunez, Marlon V, Guntrum, Michael C, Shiekh, Sajad, Balci, Hamza

“…We present a collection of single molecule work on the i-motif structure formed by the human telomeric sequence. Even though it was largely ignored in earlier…”
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Smectic-B phase and temperature-driven smectic-B to -A transition in concentrated solutions of “gapped” DNA by Gyawali, Prabesh, Saha, Rony, Kodikara, Sineth G., Li, Ruipeng, Fukuto, Masafumi, Gleeson, James T., Smith, Gregory P., Clark, Noel A., Jakli, Antal, Balci, Hamza, Sprunt, Samuel

“…The occurrence of a smectic-B (Sm-B) phase is demonstrated in concentrated aqueous solutions of “gapped” DNA constructs consisting of fully paired duplexes…”
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Single-Molecule Nanopositioning: Structural Transitions of a Helicase-DNA Complex during ATP Hydrolysis by Balci, Hamza, Arslan, Sinan, Myong, Sua, Lohman, Timothy M., Ha, Taekjip

“…The conformational states of Escherichia coli Rep helicase undergoing ATP hydrolysis while bound to a partial-duplex DNA (pdDNA) were studied using…”
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Evolution of superconductivity in electron-doped cuprates : Magneto-Raman spectroscopy by QAZILBASH, M. M, KOITZSCH, A, DENNIS, B. S, GOZAR, A, BALCI, Hamza, KENDZIORA, C. A, GREENE, R. L, BLUMBERG, G

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G-Quadruplex-Helicase Interactions and the Impact of Small Molecules by Maleki, Parastoo, Balci, Hamza

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Structure, Topology, and Stability of Multiple G-quadruplexes in Long Telomeric Overhangs by Shiekh, Sajad, Kodikara, Sineth G, Balci, Hamza

“…Telomeres and their single stranded overhangs gradually shorten with successive cell divisions, as part of the natural aging process, but can be elongated by…”
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Targeting G‑quadruplex Forming Sequences with Cas9 by Balci, Hamza, Globyte, Viktorija, Joo, Chirlmin

“…Clustered regularly interspaced palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins, particularly Cas9, have provided unprecedented control on…”
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Advances in single-molecule fluorescence methods for molecular biology by Joo, Chirlmin, Balci, Hamza, Ishitsuka, Yuji, Buranachai, Chittanon, Ha, Taekjip

“…Ever since their introduction two decades ago, single-molecule (SM) fluorescence methods have matured and branched out to address numerous biological…”
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Impact of molecular crowding conditions on stability, folding landscape, and accessibility of long telomeric sequences by Mustafa, Golam, Shiekh, Sajad A., Hoque, Mohammed E., Balci, Hamza

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