Search Results - "Balcazar, Dario"

High-throughput drug repositioning for the discovery of new treatments for Chagas disease by Bellera, Carolina L, Sbaraglini, Maria L, Balcazar, Dario E, Fraccaroli, Laura, Vanrell, M Cristina, Casassa, A Florencia, Labriola, Carlos A, Romano, Patricia S, Carrillo, Carolina, Talevi, Alan

“…Despite affecting around 8 million people worldwide and representing an economic burden above $7 billion/ year, currently approved medications to treat Chagas…”
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Detection of Flaviviral-Like DNA Sequences in Aedes aegypti (Diptera: Culicidae) Collected From Argentina by Bonica, Melisa B, Balcazar, Dario E, Chuchuy, Ailen, Barneche, Jorge A, Torres, Carolina, Micieli, María V

“…Diseases caused by flaviviruses are a major public health burden across the world. In the past decades, South America has suffered dengue epidemics, the…”
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Application of Computer-Aided Drug Repurposing in the Search of New Cruzipain Inhibitors: Discovery of Amiodarone and Bromocriptine Inhibitory Effects by Bellera, Carolina L, Balcazar, Darío E, Alberca, Lucas, Labriola, Carlos A, Talevi, Alan, Carrillo, Carolina

“…Cruzipain (Cz) is the major cystein protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. From a 163 compound data set, a…”
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SERCA is critical to control the Bowditch effect in the heart by Balcazar, Darío, Regge, Victoria, Santalla, Manuela, Meyer, Heiko, Paululat, Achim, Mattiazzi, Alicia, Ferrero, Paola

“…The Bowditch effect or staircase phenomenon is the increment or reduction of contractile force when heart rate increases, defined as either a positive or…”
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Smoking flies: testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster by Santalla, Manuela, Pagola, Lucía, Gómez, Ivana, Balcazar, Darío, Valverde, Carlos A, Ferrero, Paola

“…Studies about the relationship between substances consumed by humans and their impact on health, in animal models, have been a challenge due to differences…”
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The regulation of autophagy differentially affects Trypanosoma cruzi metacyclogenesis by Vanrell, María Cristina, Losinno, Antonella Denisse, Cueto, Juan Agustín, Balcazar, Darío, Fraccaroli, Laura Virginia, Carrillo, Carolina, Romano, Patricia Silvia

“…Autophagy is a cellular process required for the removal of aged organelles and cytosolic components through lysosomal degradation. All types of eukaryotic…”
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Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir by Bellera, Carolina L., Balcazar, Darío E., Vanrell, M. Cristina, Casassa, A. Florencia, Palestro, Pablo H., Gavernet, Luciana, Labriola, Carlos A., Gálvez, Jorge, Bruno-Blanch, Luis E., Romano, Patricia S., Carrillo, Carolina, Talevi, Alan

“…In spite of remarkable advances in the knowledge on Trypanosoma cruzi biology, no medications to treat Chagas disease have been approved in the last 40 years…”
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Diversity and abundance of free-living nematodes from Carlini Station, 25 de Mayo/King George Island, Antarctica: a case study in pristine and disturbed soils by Salas, Augusto, Fusaro, Bruno, Rusconi, José Matías, Rosales, Matías, Balcazar, Darío, Achinelly, Fernanda, Chaves, Eliseo, Sauka, Diego, Ruberto, Lucas, Ansaldo, Martín

“…The Antarctic continent hosts life forms specially adapted to the extreme climatic challenges. Among these organisms are nematodes, key organisms in the…”
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Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids by Fraccaroli, Laura, Ruiz, María Daniela, Perdomo, Virginia Gabriela, Clausi, Agustina Nicole, Balcazar, Darío Emmanuel, Larocca, Luciana, Carrillo, Carolina

“…Chagas disease is an endemic American parasitosis, caused by Trypanosoma cruzi . The current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited…”
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Identification of Levothyroxine Antichagasic Activity through Computer-Aided Drug Repurposing by Carrillo, Carolina, Talevi, Alan, Labriola, Carlos A., Alberca, Lucas, Balcazar, Darío E., Bellera, Carolina L.

“…Cruzipain (Cz) is the major cysteine protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. A conformation-independent classifier…”
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Amphimermis enzoni n. sp. (Nematoda: Mermithidae) parasitizing damselflies and dragonflies in Argentina by Rusconi, José Matias, Di Battista, Cristian, Balcazar, Darío, Rosales, Matías, Achinelly, María Fernanda

“…A mermithid nematode was found parasitizing nymphs of dragonflies and damselflies. The host specimens were collected from the stream Cajaravilla, Magdalena,…”
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The superfamily keeps growing: Identification in trypanosomatids of RibJ, the first riboflavin transporter family in protists by Balcazar, Darío E, Vanrell, María Cristina, Romano, Patricia S, Pereira, Claudio A, Goldbaum, Fernando A, Bonomi, Hernán R, Carrillo, Carolina

“…Trypanosomatid parasites represent a major health issue affecting hundreds of million people worldwide, with clinical treatments that are partially effective…”
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Trypanosoma cruzi Polyamine Transporter: Its Role on Parasite Growth and Survival Under Stress Conditions by Reigada, Chantal, Sayé, Melisa, Vera, Edward Valera, Balcazar, Darío, Fraccaroli, Laura, Carrillo, Carolina, Miranda, Mariana R., Pereira, Claudio A.

“…Trypanosoma cruzi is the etiological agent of Chagas disease, a major health problem in Latin America. Polyamines are polycationic compounds that play a…”
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Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning by Alberca, Lucas N., Sbaraglini, María L., Balcazar, Darío, Fraccaroli, Laura, Carrillo, Carolina, Medeiros, Andrea, Benitez, Diego, Comini, Marcelo, Talevi, Alan

“…Chagas disease is a parasitic infection caused by the protozoa Trypanosoma cruzi that affects about 6 million people in Latin America. Despite its sanitary…”
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Novel 2-arylazoimidazole derivatives as inhibitors of Trypanosoma cruzi proliferation: Synthesis and evaluation of their biological activity by Salerno, Alejandra, Celentano, Ana M., López, Julieta, Lara, Virginia, Gaozza, Carlos, Balcazar, Darío E., Carrillo, Carolina, Frank, Fernanda M., Blanco, María M.

“…In this work, the synthesis of a series of 2-arylazoimidazole derivatives 6–20 has been achieved through the reaction of imidazole with aryldiazonium salts,…”
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Morphological and molecular characterization of Geraldius galapagoensis (Nematoda: Chambersiellidae) associated with lichens in Argentina by Rusconi, José Matías, García, Renato, Salas, Augusto, Balcazar, Darío, Shimabukuro, Marina Ibáñez, Achinelly, María Fernanda

“…Lichens are symbiotic organisms, usually composed of a fungal partner, the mycobiont, and one or more photosynthetic partners, the photobiont, which is most…”
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A new wild strain of Caenorhabditis elegans associated with Allograpta exotica (Syrphidae) in Argentina: an update of its ecological niche and worldwide distribution by SALAS, AUGUSTO, RUSCONI, JOSÉ M., ROCCA, MARGARITA, LUCAS, FLORENCIA D., BALCAZAR, DARÍO, ACHINELLY, MARÍA FERNANDA

“…Abstract Caenorhabditis elegans is a free-living nematode, belonging to the bacterivorous trophic group. Although it was cited in several countries, in…”
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Molecular evidence supports the validity of three Parabrachiella species infecting mugilids by Montes, Martin Miguel, Castro-Romero, Raul, Öktener, Ahmet, Balcazar, Dario, Cardarella, German Flavio Reig, Martorelli, Sergio

“…•Parabrachiella mugilis is genetically different from P. exilis.•We confirmed the validity of three copepod species parasitic on mugilids.•We report for the…”
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Molecular phylogenetic relationship between Philometroides tahieli (Nematoda, Philometridae) and other philometrids from South America by Montes, Martin Miguel, Acosta Albarracin, Martin, Barneche, Jorge, Croci, Yasmin, Balcazar, Dario, Reig Cardarella, German Flavio, Martorelli, Sergio Roberto

“…In South America, the family Philometridae is represented by several genera and species. In particular, Philometra and Philometroides are the most speciose…”
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