Search Results - "Balboni Iniguez, Amanda"

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells by Kim, Jong Wook, Berrios, Christian, Kim, Miju, Schade, Amy E, Adelmant, Guillaume, Yeerna, Huwate, Damato, Emily, Iniguez, Amanda Balboni, Florens, Laurence, Washburn, Michael P, Stegmaier, Kim, Gray, Nathanael S, Tamayo, Pablo, Gjoerup, Ole, Marto, Jarrod A, DeCaprio, James, Hahn, William C

“…Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell…”
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EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma by Gorthi, Aparna, Romero, July Carolina, Loranc, Eva, Cao, Lin, Lawrence, Liesl A., Goodale, Elicia, Iniguez, Amanda Balboni, Bernard, Xavier, Masamsetti, V. Pragathi, Roston, Sydney, Lawlor, Elizabeth R., Toretsky, Jeffrey A., Stegmaier, Kimberly, Lessnick, Stephen L., Chen, Yidong, Bishop, Alexander J. R.

“…The EWS–FLI1 fusion protein, expressed in Ewing sarcoma, increases global transcription, causes accumulation of R loops and replication stress, and impairs…”
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Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma by Stolte, Björn, Iniguez, Amanda Balboni, Dharia, Neekesh V, Robichaud, Amanda L, Conway, Amy Saur, Morgan, Ann M, Alexe, Gabriela, Schauer, Nathan J, Liu, Xiaoxi, Bird, Gregory H, Tsherniak, Aviad, Vazquez, Francisca, Buhrlage, Sara J, Walensky, Loren D, Stegmaier, Kimberly

“…Ewing sarcoma is a pediatric cancer driven by EWS-ETS transcription factor fusion oncoproteins in an otherwise stable genomic background. The majority of…”
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The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53 by Yi, Joanna S., Sias-Garcia, Oscar, Nasholm, Nicole, Hu, Xiaoyu, Iniguez, Amanda Balboni, Hall, Matthew D., Davis, Mindy, Guha, Rajarshi, Moreno-Smith, Myrthala, Barbieri, Eveline, Duong, Kevin, Koach, Jessica, Qi, Jun, Bradner, James E., Stegmaier, Kimberly, Weiss, William A., Gustafson, W. Clay

“…Amplification of MYCN is a poor prognostic feature in neuroblastoma (NBL) indicating aggressive disease. We and others have shown BET bromodomain inhibitors…”
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Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry by Durbin, Adam D., Zimmerman, Mark W., Dharia, Neekesh V., Abraham, Brian J., Iniguez, Amanda Balboni, Weichert-Leahey, Nina, He, Shuning, Krill-Burger, John M., Root, David E., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Golub, Todd R., Young, Richard A., Look, A. Thomas, Stegmaier, Kimberly

“…Childhood high-risk neuroblastomas with MYCN gene amplification are difficult to treat effectively 1 . This has focused attention on tumor-specific gene…”
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EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma by Iniguez, Amanda Balboni, Stolte, Björn, Wang, Emily Jue, Conway, Amy Saur, Alexe, Gabriela, Dharia, Neekesh V., Kwiatkowski, Nicholas, Zhang, Tinghu, Abraham, Brian J., Mora, Jaume, Kalev, Peter, Leggett, Alan, Chowdhury, Dipanjan, Benes, Cyril H., Young, Richard A., Gray, Nathanael S., Stegmaier, Kimberly

“…Many cancer types are driven by oncogenic transcription factors that have been difficult to drug. Transcriptional inhibitors, however, may offer inroads into…”
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Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling by Iniguez, Amanda Balboni, Alexe, Gabriela, Wang, Emily Jue, Roti, Giovanni, Patel, Sarvagna, Chen, Liying, Kitara, Samuel, Conway, Amy, Robichaud, Amanda L., Stolte, Björn, Bandopadhayay, Pratiti, Goodale, Amy, Pantel, Sasha, Lee, Yenarae, Cheff, Dorian M., Hall, Matthew D., Guha, Rajarshi, Davis, Mindy I., Menard, Marie, Nasholm, Nicole, Weiss, William A., Qi, Jun, Beroukhim, Rameen, Piccioni, Federica, Johannessen, Cory, Stegmaier, Kimberly

“…Drug resistance represents a major challenge to achieving durable responses to cancer therapeutics. Resistance mechanisms to epigenetically targeted drugs…”
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CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2 by Chen, Liying, Alexe, Gabriela, Dharia, Neekesh V, Ross, Linda, Iniguez, Amanda Balboni, Conway, Amy Saur, Wang, Emily Jue, Veschi, Veronica, Lam, Norris, Qi, Jun, Gustafson, W Clay, Nasholm, Nicole, Vazquez, Francisca, Weir, Barbara A, Cowley, Glenn S, Ali, Levi D, Pantel, Sasha, Jiang, Guozhi, Harrington, William F, Lee, Yenarae, Goodale, Amy, Lubonja, Rakela, Krill-Burger, John M, Meyers, Robin M, Tsherniak, Aviad, Root, David E, Bradner, James E, Golub, Todd R, Roberts, Charles Wm, Hahn, William C, Weiss, William A, Thiele, Carol J, Stegmaier, Kimberly

“…Pharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma,…”
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Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma by Jiang, Baishan, Jiang, Jie, Kaltheuner, Ines H., Iniguez, Amanda Balboni, Anand, Kanchan, Ferguson, Fleur M., Ficarro, Scott B., Seong, Bo Kyung Alex, Greifenberg, Ann Katrin, Dust, Sofia, Kwiatkowski, Nicholas P., Marto, Jarrod A., Stegmaier, Kimberly, Zhang, Tinghu, Geyer, Matthias, Gray, Nathanael S.

“…Development of inhibitors targeting CDK12/13 is of increasing interest as a potential therapy for cancers as these compounds inhibit transcription of DNA…”
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STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma by Adane, Biniam, Alexe, Gabriela, Seong, Bo Kyung A., Lu, Diana, Hwang, Elizabeth E., Hnisz, Denes, Lareau, Caleb A., Ross, Linda, Lin, Shan, Dela Cruz, Filemon S., Richardson, Melissa, Weintraub, Abraham S., Wang, Sarah, Iniguez, Amanda Balboni, Dharia, Neekesh V., Conway, Amy Saur, Robichaud, Amanda L., Tanenbaum, Benjamin, Krill-Burger, John M., Vazquez, Francisca, Schenone, Monica, Berman, Jason N., Kung, Andrew L., Carr, Steven A., Aryee, Martin J., Young, Richard A., Crompton, Brian D., Stegmaier, Kimberly

“…The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological role is less clear. Here, we demonstrate that cohesin complexes…”
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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma by Bandopadhayay, Pratiti, Piccioni, Federica, O’Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred C., Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B., Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen

“…BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. However, the mechanisms for its action, and ultimately for…”
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EWSFLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma by Gorthi, Aparna, Romero, July Carolina, Loranc, Eva, Cao, Lin, Lawrence, Liesl A, Goodale, Elicia, Iniguez, Amanda Balboni, Bernard, Xavier, Masamsetti, V. Pragathi, Roston, Sydney, Lawlor, Elizabeth R, Toretsky, Jeffrey A, Stegmaier, Kimberly, Lessnick, Stephen L, Chen, Yidong, Bishop, Alexander J. R

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MEDU-36. BCL2 FAMILY MEMBERS ATTENUATE RESPONSE OF MYC-DRIVEN MEDULLOBLASTOMAS TO BET-BROMODOMAIN INHIBITION by Clymer, Jessica, Gionet, Gabrielle, Gonzalez, Elizabeth, Buchan, Graham, Qian, Kenin, Ho, Patricia, O’Rourke, Ryan, Balboni-Iniguez, Amanda, Stegmaier, Kimberley, Ligon, Keith, Piccioni, Federica, Johannessen, Cory, Beroukhim, Rameen, Bandopadhayay, Pratiti

“…Abstract BACKGROUND: BET-bromodomain proteins bind to H3K27ac enhancers and recruit transcriptional proteins to facilitate the expression of genes. Inhibition…”
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Author Correction: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma by Gorthi, Aparna, Romero, July Carolina, Loranc, Eva, Cao, Lin, Lawrence, Liesl A., Goodale, Elicia, Iniguez, Amanda Balboni, Bernard, Xavier, Masamsetti, V. Pragathi, Roston, Sydney, Lawlor, Elizabeth R., Toretsky, Jeffrey A., Stegmaier, Kimberly, Lessnick, Stephen L., Chen, Yidong, Bishop, Alexander J. R.

“…In this Letter, the sentence beginning “This work was funded….” in the Acknowledgements should have read “CPRIT (RP140105) to J.C.R.” rather than “CPRIT…”
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Abstract 2062: Selective gene dependencies in MYCN -amplified neuroblastoma include the core transcriptional regulatory circuitry by Durbin, Adam D., Zimmerman, Mark W., Dharia, Neekesh V., Abraham, Brian J., Balboni-Iniguez, Amanda, Weichert-Leahey, Nina, He, Shuning, Krill-Burger, John M., Root, David E., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Golub, Todd R., Young, Richard A., Look, A. Thomas, Stegmaier, Kimberly

“…Abstract Childhood neuroblastomas with MYCN gene amplification form a particularly high-risk subset of this disease and are difficult to treat effectively…”
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Abstract 2352: Defining a pediatric cancer dependency map by Dharia, Neekesh V., Malone, Clare, Iniguez, Amanda Balboni, Guenther, Lillian, Chen, Liying, Alexe, Gabriela, Durbin, Adam D., Zimmerman, Mark W., Hong, Andrew, Bandopadhayay, Pratiti, Filbin, Mariella G., Howard, Thomas, Paolella, Brenton, Fung, Iris, Lee, Josephine, Montgomery, Phil, Krill-Burger, John M., Abraham, Brian J., Roth, Jennifer, Root, David E., Young, Richard A., Look, A. Thomas, Beroukhim, Rameen, Boehm, Jesse S., Hahn, William C., Golub, Todd R., Tsherniak, Aviad, Vazquez, Francisca, Stegmaier, Kimberly

“…Abstract Many children with metastatic or recurrent pediatric solid tumors continue to have poor survival, and there is an immense need to identify novel…”
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MEDU-37. NEURONAL DIFFERENTIATION AND CELL-CYCLE PROGRAMS MEDIATE RESPONSE AND RESISTANCE TO BET-BROMODOMAIN INHIBITION IN MYC-DRIVEN MEDULLOBLASTOMA by Bandopadhayay, Pratiti, Piccioni, Federica, O’Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth, Gionet, Gabrielle, Qian, Kenin, Clymer, Jessica, Balboni-Iniguez, Amanda, Lam, Fred, Shapira, Ofer, Greenwald, Noah, Rashid, Rumana, Tiv, Hong, Coy, Shannon, Yaffe, Michael, Kieran, Mark, Gokhale, Prafulla, Stegmaier, Kimberley, Santagata, Sandro, Ligon, Keith, Johanneseen, Cory, Beroukhim, Rameen

“…Abstract BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. However, the mechanisms for its action, and…”
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CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2 by Chen, Liying, Alexe, Gabriela, Dharia, Neekesh V, Ross, Linda, Iniguez, Amanda Balboni, Conway, Amy Saur, Wang, Emily Jue, Veschi, Veronica, Lam, Norris, Qi, Jun, Gustafson, W. Clay, Nasholm, Nicole, Vazquez, Francisca, Weir, Barbara A, Cowley, Glenn S, Ali, Levi D, Pantel, Sasha, Jiang, Guozhi, Harrington, William F, Lee, Yenarae, Goodale, Amy, Lubonja, Rakela, Krill-Burger, John M, Meyers, Robin M, Tsherniak, Aviad, Root, David E, Bradner, James E, Golub, Todd R, Roberts, Charles W.M, Hahn, William C, Weiss, William A, Thiele, Carol J, Stegmaier, Kimberly

“…Pharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma,…”
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